Abstract:
:Myeloproliferative disorders frequently show deletions or rearrangements of the long arm of chromosome 13. We report here the cloning of RNF6, a new gene that maps close to the chromosome 13 breakpoint in a case of myelofibrosis with a t(4;13)(q26;q12). RNF6 is predicted to encode a 685-amino-acid protein with a coiled-coil domain and a RING-H2 finger at the amino and carboxy terminis, respectively. In addition, we have identified a novel motif, Lys-X-X-Leu/Ile-X-X-Leu/Ile (KIL motif), that is located shortly upstream of a subset of RING-H2 proteins, including RNF6. Drosophila g1, rat Neurodap1, and mouse Praja1. FISH and physical mapping indicated that RNF6 is located at 13q12.2 close to marker D13S1121, and it is oriented from telomere to centromere. RNF6 is not disrupted by the t(4;13).
journal_name
Genomicsjournal_title
Genomicsauthors
Macdonald DH,Lahiri D,Sampath A,Chase A,Sohal J,Cross NCdoi
10.1006/geno.1999.5802subject
Has Abstractpub_date
1999-05-15 00:00:00pages
94-7issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(99)95802-0journal_volume
58pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has recently been identified. We now describe the cloning, genomic localization, cDNA sequence, and expression analysis of its murine homologue, Pkd2. The cloned cDNA sequence is 5134 bp long and is predicted to encode a 96...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4920
更新日期:1997-10-01 00:00:00
abstract::The rat HNF-3 (hepatocyte nuclear factor 3) gene family encodes three transcription factors known to be important in the regulation of gene expression in liver and lung. We have cloned and characterized the mouse genes and cDNAs for HNF-3 alpha, beta, and gamma and analyzed their expression patterns in various adult t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1191
更新日期:1994-04-01 00:00:00
abstract::The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1108
更新日期:1995-07-01 00:00:00
abstract::A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" using this panel. This ordered collection of markers will aid in the assemb...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0358
更新日期:1996-07-15 00:00:00
abstract::p26, a small heat shock protein, is thought to protect Artemia embryos from stress during encystment and diapause. Full-length p26 cDNAs were compared and used to determine phylogenetic relationships between several Artemia species. The alpha-crystallin domain of p26 was the most conserved region of the protein and p2...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.02.008
更新日期:2006-08-01 00:00:00
abstract::The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90265-t
更新日期:1992-06-01 00:00:00
abstract::Identifying heterogeneity in chronic obstructive pulmonary disease (COPD) phenotypes is important for the development of personalized medicine. Genome-wide analysis was used to compare the methylation levels of peripheral blood mononuclear cell (PBMC) samples from 24 acute-exacerbation (AE) COPD patients with good/poo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.09.010
更新日期:2019-12-01 00:00:00
abstract::We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of hu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90087-6
更新日期:1989-07-01 00:00:00
abstract::Activating mutations in the ras genes are commonly found in a wide range of human tumors. We recently cloned two mammalian genes, Son of sevenless 1 (mSos1) and Son of sevenless 2 (mSos2), whose protein products appear to be important positive regulators of ras proteins. Given the proposed role of Sos proteins in ras ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1421
更新日期:1993-10-01 00:00:00
abstract::Type V collagen is a fibrillar collagen that is widely distributed in tissues as a minor component of extracellular matrix and is usually composed of one pro alpha 2 (V) and two pro alpha 1 (V) chains. In this report, recently isolated cDNA and genomic clones, which encode the pro alpha 1 (V) chain, are used as probes...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90320-r
更新日期:1992-04-01 00:00:00
abstract::Usher syndrome type 1 (USH1) is an autosomal recessive, genetically heterogeneous disorder causing severe congenital deafness, retinitis pigmentosa, and vestibular dysfunction. The USHla locus located on 14q32 has been linked to the genetic markers D14S250 and D14S78. Using D14S250 and D14S78, we have isolated two non...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4779
更新日期:1997-07-01 00:00:00
abstract::TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2012.07.006
更新日期:2012-11-01 00:00:00
abstract::The large number of redundant sequences available in nucleotide databases provides a resource for the identification of polymorphisms. Expressed polymorphisms in X-linked genes can be used to determine the inactivation status of the genes, and polymorphisms in genes that are subject to inactivation can then be used as...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6153
更新日期:2000-04-01 00:00:00
abstract::Mutations in the DKC1 gene are responsible for causing X-linked recessive dyskeratosis congenita (DKC) and a more severe allelic variant of the disease, Hoyeraal-Hreidarsson syndrome. Both diseases are characterized by progressive and fatal bone marrow failure. The nucleolar protein dyskerin is the pseudouridine synth...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6227
更新日期:2000-07-15 00:00:00
abstract::Mammalian sex chromosomes are the remnants of an ancient autosomal pair present in the ancestral mammalian karyotype. As a consequence of random decay and chromosome rearrangements over evolutionary time, Y chromosome gene repertoires differ between eutherian lineages. To investigate the gene repertoire and transcript...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.06.012
更新日期:2008-11-01 00:00:00
abstract::Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90205-9
更新日期:1990-08-01 00:00:00
abstract::Knowledge of protein subcellular localization is vitally important for both basic research and drug development. With the avalanche of protein sequences emerging in the post-genomic age, it is highly desired to develop computational tools for timely and effectively identifying their subcellular localization purely bas...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.05.017
更新日期:2019-07-01 00:00:00
abstract::Recently we isolated a cellular DNA binding protein, designated interleukin enhancer binding factor (ILF), that binds to purine-rich regulatory motifs in both the HIV-1 LTR and the IL2 promoter. Further analysis of the ILF gene reveals the existence of two mRNA species, both of which encode proteins containing the rec...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90139-j
更新日期:1992-07-01 00:00:00
abstract::The role of hyaluronan in cardiac growth has become evident, previously shown by increased myocardial levels of hyaluronan in a rat model of cardiac hypertrophy. To further investigate the role of hyaluronan and regulation of its synthesis in cardiac hypertrophy, quantitative measurements of myocardial hyaluronan conc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.04.003
更新日期:2010-08-01 00:00:00
abstract::The E2F transcription factor plays an important regulatory role in cell proliferation, mediating the expression of genes whose products are essential for inducing resting cells to enter the cell cycle and synthesize DNA. To investigate the possible involvement of E2F in hematopoietic malignancies, we isolated genomic ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80118-6
更新日期:1995-01-01 00:00:00
abstract::Human platelet/endothelial cell adhesion molecule-1 (PECAM1), an important member of the immunoglobulin gene superfamily, is widely distributed on cells of the vascular system and mediates cellular interactions through both homophilic and heterophilic adhesive mechanisms. The function of PECAM1 in vitro has begun to b...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0546
更新日期:1996-10-15 00:00:00
abstract::The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. In this report, we present a corrected genomic sequence, genomic structure, and refined chromosomal location for KiSS-1. The genomic organization of the sequence revea...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5566
更新日期:1998-11-15 00:00:00
abstract::Pulmonary surfactant consists of a complex mixture of phospholipids and several proteins essential to normal respiratory function. Two of the surfactant proteins, SP-A and SP-D, appear to have lectin-like activity relevant to the local phagocytic defense. Using polymerase chain reaction (PCR)-based somatic cell hybrid...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1324
更新日期:1993-08-01 00:00:00
abstract::RFX1 is a transacting DNA-binding regulatory factor involved in the control of MHC class II gene expression. RFX2 is a structurally very similar protein with identical DNA binding features. A member of the family of RFX factors is affected in an autosomal recessive disease, MHC class II deficient combined immunodefici...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90052-t
更新日期:1992-08-01 00:00:00
abstract::Treacher Collins syndrome is an autosomal dominant condition of bilateral craniofacial abnormalities of structures derived from the first and second branchial arches. A patient with severe manifestations of Treacher Collins syndrome and a de novo chromosomal deletion in region 4p15.32----p14 was identified. Anonymous ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90117-w
更新日期:1991-09-01 00:00:00
abstract::Genomic duplication, followed by divergence, contributes to organismal evolution. Several mechanisms, such as exon shuffling and alternative splicing, are responsible for novel gene functions, but they generate homologous domains and do not usually lead to drastic innovation. Major novelties can potentially be introdu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.06.009
更新日期:2006-12-01 00:00:00
abstract::Bacillus spp. play important roles in production of bioactive natural products with potential agricultural and medical applications. The three families of lipopeptides produced by Bacillus spp. have been most recognized for their antagonistic activity against other microbes, i.e. fengycin, iturin, and surfactin. A nov...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.011
更新日期:2021-01-01 00:00:00
abstract::We analyzed the whole genomes of cecum microbiomes of Ethiopian indigenous chickens from two distinct geographical zones: Afar (AF) district (Dulecha, 730 m above sea level) and Amhara (AM) district (Menz Gera Midir, 3300 m). Through metagenomic analysis we found that microbial populations were mainly dominated by Bac...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.11.011
更新日期:2020-03-01 00:00:00
abstract::Genes homologous to those located on human chromosome 4 (HSA4) were mapped in the bovine to determine regions of syntenic conservation among humans, mice, and cattle. Previous studies have shown that two homologs of genes on HSA4, PGM2 and PEPS, are located in bovine syntenic group U15 (chromosome 6). The homologous m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(05)80295-2
更新日期:1992-09-01 00:00:00
abstract::The human ortholog of the gene responsible for audiogenic seizure susceptibility in Frings and BUB/BnJ mice (mouse gene symbol Mass1) recently was shown to underlie Usher syndrome type IIC (USH2C). Here we report that the Mass1frings mutation is responsible for the early onset hearing impairment of BUB/BnJ mice. We fo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.02.006
更新日期:2005-05-01 00:00:00