Abstract:
:The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has recently been identified. We now describe the cloning, genomic localization, cDNA sequence, and expression analysis of its murine homologue, Pkd2. The cloned cDNA sequence is 5134 bp long and is predicted to encode a 966-amino-acid integral membrane protein with six membrane-spanning domains and intracellular NH2 and COOH termini. Pkd2 is highly conserved with 91% identity and 98% similarity to polycystin-2 at the amino acid level. Pkd2 mRNA is widely expressed in mouse tissues. Pkd2 maps to mouse Chromosome 5 and is excluded as a candidate gene for previously mapped mouse mutations resulting in a polycystic kidney phenotype.
journal_name
Genomicsjournal_title
Genomicsauthors
Wu G,Mochizuki T,Le TC,Cai Y,Hayashi T,Reynolds DM,Somlo Sdoi
10.1006/geno.1997.4920subject
Has Abstractpub_date
1997-10-01 00:00:00pages
220-3issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(97)94920-Xjournal_volume
45pub_type
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