Abstract:
:Recently we isolated a cellular DNA binding protein, designated interleukin enhancer binding factor (ILF), that binds to purine-rich regulatory motifs in both the HIV-1 LTR and the IL2 promoter. Further analysis of the ILF gene reveals the existence of two mRNA species, both of which encode proteins containing the recently described fork head DNA binding domain. Gel retardation analysis demonstrates that the portion of the ILF protein with homology to the fork head domain is sufficient to mediate DNA binding to a number of related purine-rich sequences. ILF mRNA is expressed constitutively in both lymphoid and nonlymphoid tissues. Chromosomal mapping localizes the ILF gene to human chromosome 17q25, which is a site of chromosomal translocations in some cases of human acute myelogous leukemias. These studies further characterize the structure of the cellular DNA binding protein ILF and may prove valuable in the molecular analysis of possible translocations affecting this gene.
journal_name
Genomicsjournal_title
Genomicsauthors
Li C,Lusis AJ,Sparkes R,Nirula A,Gaynor Rdoi
10.1016/0888-7543(92)90139-jsubject
Has Abstractpub_date
1992-07-01 00:00:00pages
665-71issue
3eissn
0888-7543issn
1089-8646pii
0888-7543(92)90139-Jjournal_volume
13pub_type
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