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CWLy-pred: A novel cell wall lytic enzyme identifier based on an improved MRMD feature selection method.

Abstract：

:Cell wall lytic enzymes play key roles in biochemical, morphological, genetic research and industry fields. To save time and labor costs， bioinformatic methods are usually adopted to narrow the scope of in vitro experimentation. In this paper, we established a novel machine learning (support vector machine) based identifier called CWLy-pred to identify cell wall lytic enzymes. An improved MRMD feature selection method is also proposed to select the optimal training set to avoid data redundancy. CWLy-pred obtains an accuracy of 93.067%, a sensitivity of 85.3%, a specificity of 94.8%, an MCC of 0.775 and an AUC of 0.900. It outperforms the state-of-the-art identifier in terms of accuracy, sensitivity, specificity and MCC. Our proposed model is based on a feature set of only 6 dimensions; therefore, it not only can overcome overfitting problems but can also supervise biological experiments effectively. CWLy-pred is embedded in a web application at http://server.malab.cn/CWLy-pred/index.jsp, which is accessible for free.

journal_name

Genomics

journal_title

Genomics

authors

Meng C,Wu J,Guo F,Dong B,Xu L

doi

10.1016/j.ygeno.2020.08.015

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

4715-4721

issue

6

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(20)30991-5

journal_volume

112

pub_type

杂志文章

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