Abstract:
:Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma2, gamma8, gamma10, gamma12, and gammaCone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes.
journal_name
Genomicsjournal_title
Genomicsauthors
Downes GB,Gilbert DJ,Copeland NG,Gautam N,Jenkins NAdoi
10.1006/geno.1999.5763subject
Has Abstractpub_date
1999-04-01 00:00:00pages
173-6issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(99)95763-4journal_volume
57pub_type
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