Physical mapping of the human neurotensin gene (NTS) between markers D12S1444 and D12S81 on chromosome 12q21.

Abstract:

:Neurotensin (NTS) is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional localization was available. We now confirm this assignment and place the NTS gene on the physical and cytogenetic maps. The NTS gene is located on a yeast artificial chromosome contig that contains several polymorphic markers and is close to a polymorphic marker located at 95.8 cM on the Généthon linkage map. NTS is immediately proximal to four polymorphic markers, including D12S81 (AFM102xg9) and D12S88 (AFM158yb4). Using fluorescence in situ hybridization, we map the gene cytogenetically to band 12q21.

journal_name

Genomics

journal_title

Genomics

authors

Marondel I,Renault B,Lieman J,Ward D,Kucherlapati R

doi

10.1006/geno.1996.0624

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

243-5

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(96)90624-2

journal_volume

38

pub_type

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