Abstract:
:In the present study, we have constructed an interaction network of 29 antibiotic resistant genes along with 777 interactions in E. coli O157:H7. Gene ontology analysis reveals that 94, 89 and 67 genes have roles in the cellular process, biological process and molecular function respectively. Gene complexes related to tripartite efflux pumps mdtEF-tolC and ABC family efflux pump macAB-tolC play key roles in multidrug efflux systems. It is noteworthy to mention that, 19 genes are involved in multi-efflux pumps and they play a significant role in multidrug resistance (MDR); while 18 genes are vital for fatty acid synthesis. Interestingly, we found that the four genes arnABCD are involved in both MDR and in fatty acid synthesis. Hence these genes could be targeted for new drug discovery. On the whole, our results provide a detailed understanding of the mode of MDR mechanisms in E.coli O157:H7.
journal_name
Genomicsjournal_title
Genomicsauthors
Miryala SK,Ramaiah Sdoi
10.1016/j.ygeno.2018.06.002subject
Has Abstractpub_date
2019-07-01 00:00:00pages
958-965issue
4eissn
0888-7543issn
1089-8646pii
S0888-7543(18)30266-0journal_volume
111pub_type
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