解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001029
更新日期:2021-01-04 00:00:00
abstract::Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001034
更新日期:2020-12-28 00:00:00
abstract::Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000506
更新日期:2020-12-21 00:00:00
abstract::Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. These pathological fea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001008
更新日期:2020-12-14 00:00:00
abstract::Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000948
更新日期:2020-12-07 00:00:00
abstract::The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000876
更新日期:2020-11-18 00:00:00
abstract::Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the l...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000872
更新日期:2020-11-13 00:00:00
abstract::Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000786
更新日期:2020-11-06 00:00:00
abstract::The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to adiponectin recepto...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000901
更新日期:2020-11-02 00:00:00
abstract::Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000908
更新日期:2020-10-27 00:00:00
abstract::The array of vibrissae on a rat's face is the first stage in a high-resolution tactile sensing system. Progressing from rostral to caudal in any vibrissae row results in an increase in whisker length and thickness. This may, in turn, provide a systematic map of separate tactile channels governed by the mechanical prop...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000699
更新日期:2020-10-22 00:00:00
abstract::In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time. ...
journal_title:PLoS biology
pub_type: 社论
doi:10.1371/journal.pbio.3000992
更新日期:2020-10-22 00:00:00
abstract::Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000898
更新日期:2020-10-20 00:00:00
abstract::The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately improved by analytical work, whether ensuring reproducible and well-document...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000913
更新日期:2020-10-16 00:00:00
abstract::Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000927
更新日期:2020-10-14 00:00:00
abstract::Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalami...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000829
更新日期:2020-10-13 00:00:00
abstract::Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000837
更新日期:2020-10-05 00:00:00
abstract::Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000856
更新日期:2020-09-17 00:00:00
abstract::Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000825
更新日期:2020-09-04 00:00:00
abstract::Virus proliferation involves gene replication inside infected cells and transmission to new target cells. Once positive-strand RNA virus has infected a cell, the viral genome serves as a template for copying ("stay-strategy") or is packaged into a progeny virion that will be released extracellularly ("leave-strategy")...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000562
更新日期:2020-07-30 00:00:00
abstract::The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrat...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000606
更新日期:2020-07-20 00:00:00
abstract::During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluated the epigenetic landscape of the mouse myometrium during the pregnan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000710
更新日期:2020-07-15 00:00:00
abstract::Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000712
更新日期:2020-07-14 00:00:00
abstract::Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000744
更新日期:2020-06-19 00:00:00
abstract::A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000677
更新日期:2020-06-12 00:00:00
abstract::Unc-51-like autophagy activating kinase 1 (ULK1)-autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions. However, their phospho-regul...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000288
更新日期:2020-06-09 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.3000193.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.3000752
更新日期:2020-05-18 00:00:00
abstract::Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm for the generation of vascularized organoids (vOrganoids) consis...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000705
更新日期:2020-05-13 00:00:00
abstract::5-hydroxymethylcytosine (5hmC) is the most prevalent intermediate on the oxidative DNA demethylation pathway and is implicated in regulation of embryogenesis, neurological processes, and cancerogenesis. Profiling of this relatively scarce genomic modification in clinical samples requires cost-effective high-resolution...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000684
更新日期:2020-04-10 00:00:00
abstract::Putting a name to a face is a highly common activity in our daily life that greatly enriches social interactions. Although this specific person-identity association becomes automatic with learning, it remains difficult and can easily be disrupted in normal circumstances or neurological conditions. To shed light on the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000659
更新日期:2020-04-03 00:00:00
abstract::Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000668
更新日期:2020-03-30 00:00:00
abstract::During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome-encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells. Thus-in the context of agonist treatment during IVF-these r...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000663
更新日期:2020-03-23 00:00:00
abstract::Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The female-specific neo-W chromosome of the African monarch (or queen) butterfly Danaus chrysippus presents an intriguing case study because it is restricted to a single 'contact zone' population, invol...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000610
更新日期:2020-02-27 00:00:00
abstract::Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000620
更新日期:2020-02-13 00:00:00
abstract::The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a uniqu...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000576
更新日期:2020-02-11 00:00:00
abstract::We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000583
更新日期:2020-01-23 00:00:00
abstract::Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost in cells using the alternative lengthening of telomeres (ALT) pathway, but it is not known how ATRX loss leads to ALT. We report that ATRX deletion from mouse c...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000594
更新日期:2020-01-02 00:00:00
abstract::Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000573
更新日期:2019-12-16 00:00:00
abstract::The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000546
更新日期:2019-12-09 00:00:00
abstract::Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analys...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000482
更新日期:2019-12-05 00:00:00