We need leaders that believe in scientific evidence.

abstract：:Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have und...

journal_title：PLoS biology

authors： Rea SL,Ventura N,Johnson TE

更新日期：2007-10-02 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00

abstract：:Misalignment of the daily sleep-wake and fasting-feeding cycles with the endogenous circadian timing system is an inevitable consequence of night shift work and is associated with adverse metabolic health effects. However, a detailed characterisation of the effects of night shifts on 24-h rhythms in the metabolome is ...

journal_title：PLoS biology

authors： Kervezee L,Cermakian N,Boivin DB

更新日期：2019-06-18 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in neural coding and modulates information transfer between cortic...

journal_title：PLoS biology

authors： Lowet E,Gips B,Roberts MJ,De Weerd P,Jensen O,van der Eerden J

更新日期：2018-05-31 00:00:00

abstract：:Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on the plasma lipidome in a large population cohort using advanced mach...

journal_title：PLoS biology

authors： Gerl MJ,Klose C,Surma MA,Fernandez C,Melander O,Männistö S,Borodulin K,Havulinna AS,Salomaa V,Ikonen E,Cannistraci CV,Simons K

更新日期：2019-10-18 00:00:00

abstract：:A vast and rich body of information has grown up as a result of the world's enthusiasm for 'omics technologies. Finding ways to describe and make available this information that maximise its usefulness has become a major effort across the 'omics world. At the heart of this effort is the Genomic Standards Consortium (G...

journal_title：PLoS biology

authors： Field D,Amaral-Zettler L,Cochrane G,Cole JR,Dawyndt P,Garrity GM,Gilbert J,Glöckner FO,Hirschman L,Karsch-Mizrachi I,Klenk HP,Knight R,Kottmann R,Kyrpides N,Meyer F,San Gil I,Sansone SA,Schriml LM,Sterk P,Tatusova T

更新日期：2011-06-01 00:00:00

abstract：:Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...

journal_title：PLoS biology

authors： Morlon H,Potts MD,Plotkin JB

更新日期：2010-09-28 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

journal_title：PLoS biology

authors： Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

更新日期：2018-09-27 00:00:00

abstract：:Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that these enzymes can also bind polyadenylated RNAs. Here, we explored the mRNA repertoire bound by several yeast aaRSs. RNA immunoprecipitation (RIP)...

journal_title：PLoS biology

authors： Levi O,Arava Y

更新日期：2019-05-17 00:00:00

abstract：:Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary selection. Theoretical and experimental analyses of bacterial chemotaxis suggested that the pathway has been evolutionarily optimized to produce robust output u...

journal_title：PLoS biology

authors： Løvdok L,Bentele K,Vladimirov N,Müller A,Pop FS,Lebiedz D,Kollmann M,Sourjik V

更新日期：2009-08-01 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:The mechanism by which a complex auditory scene is parsed into coherent objects depends on poorly understood interactions between task-driven and stimulus-driven attentional processes. We illuminate these interactions in a simultaneous behavioral-neurophysiological study in which we manipulate participants' attention ...

journal_title：PLoS biology

authors： Elhilali M,Xiang J,Shamma SA,Simon JZ

更新日期：2009-06-01 00:00:00

abstract：:As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexpression in females ...

journal_title：PLoS biology

authors： Julien P,Brawand D,Soumillon M,Necsulea A,Liechti A,Schütz F,Daish T,Grützner F,Kaessmann H

更新日期：2012-01-01 00:00:00

abstract：:During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluated the epigenetic landscape of the mouse myometrium during the pregnan...

journal_title：PLoS biology

authors： Shchuka VM,Abatti LE,Hou H,Khader N,Dorogin A,Wilson MD,Shynlova O,Mitchell JA

更新日期：2020-07-15 00:00:00

abstract：:Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

journal_title：PLoS biology

authors： Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

更新日期：2020-12-07 00:00:00

abstract：:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...

journal_title：PLoS biology

authors： Ricard N,Simons M

更新日期：2015-05-15 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:An increasing number of publishers and funding agencies require public data archiving (PDA) in open-access databases. PDA has obvious group benefits for the scientific community, but many researchers are reluctant to share their data publicly because of real or perceived individual costs. Improving participation in PD...

journal_title：PLoS biology

authors： Roche DG,Lanfear R,Binning SA,Haff TM,Schwanz LE,Cain KE,Kokko H,Jennions MD,Kruuk LE

更新日期：2014-01-28 00:00:00

abstract：:Animals live together with diverse bacteria that can impact their biology. In Drosophila melanogaster, gut-associated bacterial communities are relatively simple in composition but also have a strong impact on host development and physiology. It is generally assumed that gut bacteria in D. melanogaster are transient a...

journal_title：PLoS biology

authors： Pais IS,Valente RS,Sporniak M,Teixeira L

更新日期：2018-07-05 00:00:00

abstract：:Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...

journal_title：PLoS biology

authors： Hayashi MJ,Ditye T,Harada T,Hashiguchi M,Sadato N,Carlson S,Walsh V,Kanai R

更新日期：2015-09-17 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00

abstract：:The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...

journal_title：PLoS biology

authors： Kaufmann K,Muiño JM,Jauregui R,Airoldi CA,Smaczniak C,Krajewski P,Angenent GC

更新日期：2009-04-21 00:00:00

abstract：:Many living organisms transform inorganic atoms into highly ordered crystalline materials. An elegant example of such biomineralization processes is the production of nano-scale magnetic crystals in magnetotactic bacteria. Previous studies implicated the involvement of two putative serine proteases, MamE and MamO, dur...

journal_title：PLoS biology

authors： Hershey DM,Ren X,Melnyk RA,Browne PJ,Ozyamak E,Jones SR,Chang MC,Hurley JH,Komeili A

更新日期：2016-03-16 00:00:00

abstract：:The significance of symbioses between eukaryotic hosts and microbes extends from the organismal to the ecosystem level and underpins the health of Earth's most threatened marine ecosystems. Despite rapid growth in research on host-associated microbes, from individual microbial symbionts to host-associated consortia of...

journal_title：PLoS biology

authors： Wilkins LGE,Leray M,O'Dea A,Yuen B,Peixoto RS,Pereira TJ,Bik HM,Coil DA,Duffy JE,Herre EA,Lessios HA,Lucey NM,Mejia LC,Rasher DB,Sharp KH,Sogin EM,Thacker RW,Vega Thurber R,Wcislo WT,Wilbanks EG,Eisen JA

更新日期：2019-11-11 00:00:00

abstract：:It has been reported that feeding mice resveratrol activates AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1α, increased mitochondrial biogenesis, and improved running endurance. This study was done to further evaluate the effects of resveratrol, SIRT1, and PGC-1α deacetylation on mi...

journal_title：PLoS biology

authors： Higashida K,Kim SH,Jung SR,Asaka M,Holloszy JO,Han DH

更新日期：2013-07-01 00:00:00

abstract：:Unc-51-like autophagy activating kinase 1 (ULK1)-autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions. However, their phospho-regul...

journal_title：PLoS biology

authors： Li Z,Tian X,Ji X,Wang J,Chen H,Wang D,Zhang X

更新日期：2020-06-09 00:00:00

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00