ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle.

abstract：:Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluc...

journal_title：PLoS biology

authors： Frank SA,Rosner MR

更新日期：2012-01-01 00:00:00

abstract：:Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To s...

journal_title：PLoS biology

authors： Jeong JH,Lee DK,Liu SM,Chua SC Jr,Schwartz GJ,Jo YH

更新日期：2018-04-24 00:00:00

abstract：:The prospects for the success of malaria control depend, in part, on the basic reproductive number for malaria, R0. Here, we estimate R0 in a novel way for 121 African populations, and thereby increase the number of R0 estimates for malaria by an order of magnitude. The estimates range from around one to more than 3,0...

journal_title：PLoS biology

authors： Smith DL,McKenzie FE,Snow RW,Hay SI

更新日期：2007-03-01 00:00:00

abstract：:The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a uniqu...

journal_title：PLoS biology

authors： Strech D,Weissgerber T,Dirnagl U,QUEST Group.

更新日期：2020-02-11 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:Several studies have demonstrated that poor early nutrition, followed by growth compensation, can have negative consequences later in life. However, it remains unclear whether this is attributable to the nutritional deficit itself or a cost of compensatory growth. This distinction is important to our understanding bot...

journal_title：PLoS biology

authors： Fisher MO,Nager RG,Monaghan P

更新日期：2006-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002454.]. ...

journal_title：PLoS biology

authors： Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

更新日期：2018-03-14 00:00:00

abstract：:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits. ...

journal_title：PLoS biology

authors： Richardson LA

更新日期：2018-10-04 00:00:00

abstract：:The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental d...

journal_title：PLoS biology

authors： Favaro PD,Huang X,Hosang L,Stodieck S,Cui L,Liu YZ,Engelhardt KA,Schmitz F,Dong Y,Löwel S,Schlüter OM

更新日期：2018-12-26 00:00:00

abstract：:Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties, but the mechanisms regulating synapse-specific Ca2+ homeostasis in...

journal_title：PLoS biology

authors： Kwon SK,Sando R 3rd,Lewis TL,Hirabayashi Y,Maximov A,Polleux F

更新日期：2016-07-18 00:00:00

abstract：:The human gut harbours a large and genetically diverse population of symbiotic microbes that both feed and protect the host. Evolutionary theory, however, predicts that such genetic diversity can destabilise mutualistic partnerships. How then can the mutualism of the human microbiota be explained? Here we develop an i...

journal_title：PLoS biology

authors： Schluter J,Foster KR

更新日期：2012-01-01 00:00:00

abstract：:The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints du...

journal_title：PLoS biology

authors： Green AA,Kennaway JR,Hanna AI,Bangham JA,Coen E

更新日期：2010-11-09 00:00:00

abstract：:For the last 100 years, it has been uncontroversial to state that the plant germline is set aside late in development, but there is surprisingly little evidence to support this view. In contrast, much evolutionary theory and several recent empirical studies seem to suggest the opposite-that the germlines of some and p...

journal_title：PLoS biology

authors： Lanfear R

更新日期：2018-05-16 00:00:00

abstract：:Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events controlling this process in the human malaria parasite Plasmodium falcipa...

journal_title：PLoS biology

authors： McRobert L,Taylor CJ,Deng W,Fivelman QL,Cummings RM,Polley SD,Billker O,Baker DA

更新日期：2008-06-03 00:00:00

abstract：:Certain bacterial adhesins appear to promote a pathogen's extracellular lifestyle rather than its entry into host cells. However, little is known about the stimuli elicited upon such pathogen host-cell interactions. Here, we report that type IV pili (Tfp)-producing Neisseria gonorrhoeae (P(+)GC) induces an immediate r...

journal_title：PLoS biology

authors： Boettcher JP,Kirchner M,Churin Y,Kaushansky A,Pompaiah M,Thorn H,Brinkmann V,Macbeath G,Meyer TF

更新日期：2010-08-24 00:00:00

abstract：:Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the d...

journal_title：PLoS biology

authors： Liu P,Dodson M,Fang D,Chapman E,Zhang DD

更新日期：2020-02-13 00:00:00

abstract：:In all vertebrates hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. There is an extensive literature describing single gene mutations in humans that cause hearing impairment, but there are essentially none for touch. Here we firs...

journal_title：PLoS biology

authors： Frenzel H,Bohlender J,Pinsker K,Wohlleben B,Tank J,Lechner SG,Schiska D,Jaijo T,Rüschendorf F,Saar K,Jordan J,Millán JM,Gross M,Lewin GR

更新日期：2012-01-01 00:00:00

abstract：:We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

journal_title：PLoS biology

authors： Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

更新日期：2006-03-01 00:00:00

abstract：:What explains why some groups of organisms, like birds, are so species rich? And what explains their extraordinary ecological diversity, ranging from large, flightless birds to small migratory species that fly thousand of kilometers every year? These and similar questions have spurred great interest in adaptive radiat...

journal_title：PLoS biology

authors： Moen D,Morlon H

更新日期：2014-05-06 00:00:00

abstract：:Many living organisms transform inorganic atoms into highly ordered crystalline materials. An elegant example of such biomineralization processes is the production of nano-scale magnetic crystals in magnetotactic bacteria. Previous studies implicated the involvement of two putative serine proteases, MamE and MamO, dur...

journal_title：PLoS biology

authors： Hershey DM,Ren X,Melnyk RA,Browne PJ,Ozyamak E,Jones SR,Chang MC,Hurley JH,Komeili A

更新日期：2016-03-16 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00

abstract：:Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...

journal_title：PLoS biology

authors： Alerstam T,Rosén M,Bäckman J,Ericson PG,Hellgren O

更新日期：2007-08-01 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on the plasma lipidome in a large population cohort using advanced mach...

journal_title：PLoS biology

authors： Gerl MJ,Klose C,Surma MA,Fernandez C,Melander O,Männistö S,Borodulin K,Havulinna AS,Salomaa V,Ikonen E,Cannistraci CV,Simons K

更新日期：2019-10-18 00:00:00

abstract：:Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide (HX). This paradigm is at the basis of the vast majority of expe...

journal_title：PLoS biology

authors： Hudry B,Remacle S,Delfini MC,Rezsohazy R,Graba Y,Merabet S

更新日期：2012-01-01 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially i...

journal_title：PLoS biology

authors： Szamecz B,Boross G,Kalapis D,Kovács K,Fekete G,Farkas Z,Lázár V,Hrtyan M,Kemmeren P,Groot Koerkamp MJ,Rutkai E,Holstege FC,Papp B,Pál C

更新日期：2014-08-26 00:00:00

abstract：:Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-embryos display an identical phenotype, indicating that these ce...

journal_title：PLoS biology

authors： Lee KM,Wilson GJ,Pingen M,Fukuoka A,Hansell CAH,Bartolini R,Medina-Ruiz L,Graham GJ

更新日期：2019-05-29 00:00:00

abstract：:Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...

journal_title：PLoS biology

authors： Meharena HS,Fan X,Ahuja LG,Keshwani MM,McClendon CL,Chen AM,Adams JA,Taylor SS

更新日期：2016-11-30 00:00:00