REST regulates distinct transcriptional networks in embryonic and neural stem cells.

Abstract:

:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays important but distinct regulatory roles in embryonic (ESC) and neural (NSC) stem cells. We investigated how these distinct biological roles are effected at a genomic level. We present integrated, comparative genome- and transcriptome-wide analyses of transcriptional networks governed by REST in mouse ESC and NSC. The REST recruitment profile has dual components: a developmentally independent core that is common to ESC, NSC, and differentiated cells; and a large, ESC-specific set of target genes. In ESC, the REST regulatory network is highly integrated into that of pluripotency factors Oct4-Sox2-Nanog. We propose that an extensive, pluripotency-specific recruitment profile lends REST a key role in the maintenance of the ESC phenotype.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

doi

10.1371/journal.pbio.0060256

subject

Has Abstract

pub_date

2008-10-28 00:00:00

pages

e256

issue

10

eissn

1544-9173

issn

1545-7885

pii

08-PLBI-RA-1317

journal_volume

6

pub_type

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