Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:Using DNA sequences 5' to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans. This effort encompasses about 10% of all genes identified in this organism. GFP-expre...

journal_title：PLoS biology

authors： Hunt-Newbury R,Viveiros R,Johnsen R,Mah A,Anastas D,Fang L,Halfnight E,Lee D,Lin J,Lorch A,McKay S,Okada HM,Pan J,Schulz AK,Tu D,Wong K,Zhao Z,Alexeyenko A,Burglin T,Sonnhammer E,Schnabel R,Jones SJ,Marra MA,

更新日期：2007-09-01 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approxi...

journal_title：PLoS biology

authors： Freedman LP,Cockburn IM,Simcoe TS

更新日期：2015-06-09 00:00:00

abstract：:Genome-wide studies of circadian transcription or mRNA translation have been hindered by the presence of heterogeneous cell populations in complex tissues such as the nervous system. We describe here the use of a Drosophila cell-specific translational profiling approach to document the rhythmic "translatome" of neural...

journal_title：PLoS biology

authors： Huang Y,Ainsley JA,Reijmers LG,Jackson FR

更新日期：2013-11-01 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the l...

journal_title：PLoS biology

authors： Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

更新日期：2020-11-13 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...

journal_title：PLoS biology

authors： Sriram K,Moyung K,Corriden R,Carter H,Insel PA

更新日期：2019-11-25 00:00:00

abstract：:Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...

journal_title：PLoS biology

authors： Fortna A,Kim Y,MacLaren E,Marshall K,Hahn G,Meltesen L,Brenton M,Hink R,Burgers S,Hernandez-Boussard T,Karimpour-Fard A,Glueck D,McGavran L,Berry R,Pollack J,Sikela JM

更新日期：2004-07-01 00:00:00

abstract：:The rapid destruction of the planet's biodiversity has prompted the nations of the world to set a target of achieving a significant reduction in the rate of loss of biodiversity by 2010. However, we do not yet have an adequate way of monitoring progress towards achieving this target. Here we present a method for produ...

journal_title：PLoS biology

authors： Butchart SH,Stattersfield AJ,Bennun LA,Shutes SM,Akçakaya HR,Baillie JE,Stuart SN,Hilton-Taylor C,Mace GM

更新日期：2004-12-01 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex I are involved in a wide range of degenerative disorders. Recent...

journal_title：PLoS biology

authors： Dröse S,Krack S,Sokolova L,Zwicker K,Barth HD,Morgner N,Heide H,Steger M,Nübel E,Zickermann V,Kerscher S,Brutschy B,Radermacher M,Brandt U

更新日期：2011-08-01 00:00:00

abstract：:Despite many prior studies demonstrating offline behavioral gains in motor skills after sleep, the underlying neural mechanisms remain poorly understood. To investigate the neurophysiological basis for offline gains, we performed single-unit recordings in motor cortex as rats learned a skilled upper-limb task. We foun...

journal_title：PLoS biology

authors： Ramanathan DS,Gulati T,Ganguly K

更新日期：2015-09-18 00:00:00

abstract：:In an age of free international shipments of mail-ordered seeds and plants, more policing will not stop the global migration of hitchhiking pests. The solution is in a preemptive response based on an internationally coordinated genomic deployment of global biodiversity in the largest breeding project since the "Garden...

journal_title：PLoS biology

authors： Zamir D

更新日期：2016-04-19 00:00:00

abstract：:The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcript...

journal_title：PLoS biology

authors： Meeske AJ,Rodrigues CD,Brady J,Lim HC,Bernhardt TG,Rudner DZ

更新日期：2016-01-06 00:00:00

abstract：:Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic g...

journal_title：PLoS biology

authors： Levy SF,Ziv N,Siegal ML

更新日期：2012-01-01 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided...

journal_title：PLoS biology

authors： Waibel M,Floreano D,Keller L

更新日期：2011-05-01 00:00:00

abstract：:A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...

journal_title：PLoS biology

authors： Bahramisharif A,Jensen O,Jacobs J,Lisman J

更新日期：2018-08-15 00:00:00

abstract：:The region of the ancient Sahul continent (present day Australia and New Guinea, and surrounding islands) is home to extreme linguistic diversity. Even apart from the huge Austronesian language family, which spread into the area after the breakup of the Sahul continent in the Holocene, there are hundreds of languages ...

journal_title：PLoS biology

authors： Reesink G,Singer R,Dunn M

更新日期：2009-11-01 00:00:00

abstract：:The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep dep...

journal_title：PLoS biology

authors： Porrino LJ,Daunais JB,Rogers GA,Hampson RE,Deadwyler SA

更新日期：2005-09-01 00:00:00

abstract：:The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

journal_title：PLoS biology

authors： Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

更新日期：2013-01-01 00:00:00

abstract：:How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance--the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively we...

journal_title：PLoS biology

authors： Råberg L

更新日期：2014-11-04 00:00:00

abstract：:Mimivirus is the largest known virus whose genome and physical size are comparable to some small bacteria, blurring the boundary between a virus and a cell. Structural studies of Mimivirus have been difficult because of its size and long surface fibers. Here we report the use of enzymatic digestions to remove the surf...

journal_title：PLoS biology

authors： Xiao C,Kuznetsov YG,Sun S,Hafenstein SL,Kostyuchenko VA,Chipman PR,Suzan-Monti M,Raoult D,McPherson A,Rossmann MG

更新日期：2009-04-28 00:00:00

abstract：:Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS1...

journal_title：PLoS biology

authors： Cao Y,Xu H,Zhu Y,Shi MJ,Wei L,Zhang J,Cheng S,Shi Y,Tong H,Kang L,Lu L,Luo H,Yang X,Bai X,Wang R,Ma Y,Wang Y,Wang Z,Zhong K,Zhao BQ,Fan W

更新日期：2019-06-11 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:Virus proliferation involves gene replication inside infected cells and transmission to new target cells. Once positive-strand RNA virus has infected a cell, the viral genome serves as a template for copying ("stay-strategy") or is packaged into a progeny virion that will be released extracellularly ("leave-strategy")...

journal_title：PLoS biology

authors： Iwanami S,Kitagawa K,Ohashi H,Asai Y,Shionoya K,Saso W,Nishioka K,Inaba H,Nakaoka S,Wakita T,Diekmann O,Iwami S,Watashi K

更新日期：2020-07-30 00:00:00

abstract：:Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and p...

journal_title：PLoS biology

authors： Nuismer SL,Otto SP

更新日期：2005-07-01 00:00:00

abstract：:Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...

journal_title：PLoS biology

authors： Maia Chagas A

更新日期：2018-09-27 00:00:00