Microstructural and functional gradients are increasingly dissociated in transmodal cortices.

abstract：:The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately improved by analytical work, whether ensuring reproducible and well-document...

journal_title：PLoS biology

authors： Kucharski AJ,Funk S,Eggo RM

更新日期：2020-10-16 00:00:00

abstract：:The recent United States measles epidemic has sparked another contentious national discussion about childhood vaccination. A growing number of parents are expressing concerns about the safety of vaccines, often fueled by misinformation from the internet, books, and other nonmedical sources. Many of these concerned par...

journal_title：PLoS biology

authors： Glanz JM,Kraus CR,Daley MF

更新日期：2015-08-07 00:00:00

abstract：:In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...

journal_title：PLoS biology

authors： Stevens SLR,Kuzak M,Martinez C,Moser A,Bleeker P,Galland M

更新日期：2018-11-28 00:00:00

abstract：:Glial cells surround neuronal endings to create enclosed compartments required for neuronal function. This architecture is seen at excitatory synapses and at sensory neuron receptive endings. Despite the prevalence and importance of these compartments, how they form is not known. We used the main sensory organ of C. e...

journal_title：PLoS biology

authors： Oikonomou G,Perens EA,Lu Y,Watanabe S,Jorgensen EM,Shaham S

更新日期：2011-08-01 00:00:00

abstract：:The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP hydrolysis. When filaments form on duplex DNA, RecA protein exhibits a fu...

journal_title：PLoS biology

authors： Cox JM,Tsodikov OV,Cox MM

更新日期：2005-02-01 00:00:00

abstract：:Over the past two decades, neuroscientists have increasingly turned their attention to the question of how the brain implements decisions between differently valued options. This emerging field, called neuroeconomics, has made quick progress in identifying a plethora of brain areas that track or are modulated by rewar...

journal_title：PLoS biology

authors： Stott JJ,Redish AD

更新日期：2015-06-18 00:00:00

abstract：:The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of the misfolded chan...

journal_title：PLoS biology

authors： Veit G,Oliver K,Apaja PM,Perdomo D,Bidaud-Meynard A,Lin ST,Guo J,Icyuz M,Sorscher EJ,Hartman JL IV,Lukacs GL

更新日期：2016-05-11 00:00:00

abstract：:Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus. In yeast, a large set of UPR target genes has been experimentally determined, but the previo...

journal_title：PLoS biology

authors： Patil CK,Li H,Walter P

更新日期：2004-08-01 00:00:00

abstract：:How often do people visit the world's protected areas (PAs)? Despite PAs covering one-eighth of the land and being a major focus of nature-based recreation and tourism, we don't know. To address this, we compiled a globally-representative database of visits to PAs and built region-specific models predicting visit rate...

journal_title：PLoS biology

authors： Balmford A,Green JM,Anderson M,Beresford J,Huang C,Naidoo R,Walpole M,Manica A

更新日期：2015-02-24 00:00:00

abstract：:Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...

journal_title：PLoS biology

authors： Hernandez-Sanchez W,Huang W,Plucinsky B,Garcia-Vazquez N,Robinson NJ,Schiemann WP,Berdis AJ,Skordalakes E,Taylor DJ

更新日期：2019-04-05 00:00:00

abstract：:The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated wh...

journal_title：PLoS biology

authors： Menacho-Márquez M,García-Escudero R,Ojeda V,Abad A,Delgado P,Costa C,Ruiz S,Alarcón B,Paramio JM,Bustelo XR

更新日期：2013-07-01 00:00:00

abstract：:Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic...

journal_title：PLoS biology

authors： Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK

更新日期：2009-11-01 00:00:00

abstract：:Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...

journal_title：PLoS biology

authors： Knapp BD,Zhu L,Huang KC

更新日期：2020-11-06 00:00:00

abstract：:FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...

journal_title：PLoS biology

authors： Strauss MP,Liew AT,Turnbull L,Whitchurch CB,Monahan LG,Harry EJ

更新日期：2012-01-01 00:00:00

abstract：:In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown. ...

journal_title：PLoS biology

authors： Stoeger T,Gerlach M,Morimoto RI,Amaral LAN

更新日期：2018-12-11 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm for the generation of vascularized organoids (vOrganoids) consis...

journal_title：PLoS biology

authors： Shi Y,Sun L,Wang M,Liu J,Zhong S,Li R,Li P,Guo L,Fang A,Chen R,Ge WP,Wu Q,Wang X

更新日期：2020-05-13 00:00:00

abstract：:Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a closed conformation. Since closed syntaxin is unable to interact ...

journal_title：PLoS biology

authors： Zilly FE,Sørensen JB,Jahn R,Lang T

更新日期：2006-10-01 00:00:00

abstract：:What explains why some groups of organisms, like birds, are so species rich? And what explains their extraordinary ecological diversity, ranging from large, flightless birds to small migratory species that fly thousand of kilometers every year? These and similar questions have spurred great interest in adaptive radiat...

journal_title：PLoS biology

authors： Moen D,Morlon H

更新日期：2014-05-06 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...

journal_title：PLoS biology

authors： Sriram K,Moyung K,Corriden R,Carter H,Insel PA

更新日期：2019-11-25 00:00:00

abstract：:RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs). RNA-induced silencing complexes (RISC) in human cells can be programmed by exogenously in...

journal_title：PLoS biology

authors： Chu CY,Rana TM

更新日期：2006-07-01 00:00:00

abstract：:In photosynthetic organisms, feedback dissipation of excess absorbed light energy balances harvesting of light with metabolic energy consumption. This mechanism prevents photodamage caused by reactive oxygen species produced by the reaction of chlorophyll (Chl) triplet states with O₂. Plants have been found to perform...

journal_title：PLoS biology

authors： Bonente G,Ballottari M,Truong TB,Morosinotto T,Ahn TK,Fleming GR,Niyogi KK,Bassi R

更新日期：2011-01-18 00:00:00

abstract：:PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...

journal_title：PLoS biology

authors： Raia P,Carroni M,Henry E,Pehau-Arnaudet G,Brûlé S,Béguin P,Henneke G,Lindahl E,Delarue M,Sauguet L

更新日期：2019-01-18 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:A large repertoire of natural object manipulation tasks require precisely coupled symmetrical opposing forces by both hands on a single object. We asked how the lateralized brain handles this basic problem of spatial and temporal coordination. We show that the brain consistently appoints one of the hands as prime acto...

journal_title：PLoS biology

authors： Johansson RS,Theorin A,Westling G,Andersson M,Ohki Y,Nyberg L

更新日期：2006-06-01 00:00:00

abstract：:Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial. Much recent research has emphasised the adaptive benefit of acquiring novel DNA, but here we argue instead that intragenomic conflict provides a coherent framewo...

journal_title：PLoS biology

authors： Croucher NJ,Mostowy R,Wymant C,Turner P,Bentley SD,Fraser C

更新日期：2016-03-02 00:00:00

abstract：:We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...

journal_title：PLoS biology

authors： Ale-Agha N,Goy C,Jakobs P,Spyridopoulos I,Gonnissen S,Dyballa-Rukes N,Aufenvenne K,von Ameln F,Zurek M,Spannbrucker T,Eckermann O,Jakob S,Gorressen S,Abrams M,Grandoch M,Fischer JW,Köhrer K,Deenen R,Unfried K,Altsch

更新日期：2018-06-21 00:00:00

abstract：:The segmentation gene network of Drosophila consists of maternal and zygotic factors that generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity along the anterior-posterior axis of the embryo. Using known binding site information for maternal and zygotic gap transcription facto...

journal_title：PLoS biology

authors： Schroeder MD,Pearce M,Fak J,Fan H,Unnerstall U,Emberly E,Rajewsky N,Siggia ED,Gaul U

更新日期：2004-09-01 00:00:00

abstract：:Sixty-five years after Turing first revealed the potential of systems with local activation and long-range inhibition to generate pattern, we have only recently begun to identify the biological elements that operate at many scales to generate periodic patterns in nature. In this Primer, we first review the theoretical...

journal_title：PLoS biology

authors： Dalle Nogare D,Chitnis AB

更新日期：2017-12-20 00:00:00