Walk on the wild side: estimating the global magnitude of visits to protected areas.

abstract：:The rapid destruction of the planet's biodiversity has prompted the nations of the world to set a target of achieving a significant reduction in the rate of loss of biodiversity by 2010. However, we do not yet have an adequate way of monitoring progress towards achieving this target. Here we present a method for produ...

journal_title：PLoS biology

authors： Butchart SH,Stattersfield AJ,Bennun LA,Shutes SM,Akçakaya HR,Baillie JE,Stuart SN,Hilton-Taylor C,Mace GM

更新日期：2004-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002125.]. ...

journal_title：PLoS biology

authors： Franco CA,Jones ML,Bernabeu MO,Geudens I,Mathivet T,Rosa A,Lopes FM,Lima AP,Ragab A,Collins RT,Phng LK,Coveney PV,Gerhardt H

更新日期：2015-05-14 00:00:00

abstract：:Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic g...

journal_title：PLoS biology

authors： Levy SF,Ziv N,Siegal ML

更新日期：2012-01-01 00:00:00

abstract：:Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...

journal_title：PLoS biology

authors： Lozoya OA,Martinez-Reyes I,Wang T,Grenet D,Bushel P,Li J,Chandel N,Woychik RP,Santos JH

更新日期：2018-04-18 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...

journal_title：PLoS biology

authors： Hoehl S,Markova G

更新日期：2018-12-13 00:00:00

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00

abstract：:The transcription rate of a gene is often controlled by several regulators that bind specific sites in the gene's cis-regulatory region. The combined effect of these regulators is described by a cis-regulatory input function. What determines the form of an input function, and how variable is it with respect to mutatio...

journal_title：PLoS biology

authors： Mayo AE,Setty Y,Shavit S,Zaslaver A,Alon U

更新日期：2006-04-01 00:00:00

abstract：:Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...

journal_title：PLoS biology

authors： Moore JD,Mercer Lindsay N,Deschênes M,Kleinfeld D

更新日期：2015-09-22 00:00:00

abstract：:The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...

journal_title：PLoS biology

authors： San Pietro E,Capestrano M,Polishchuk EV,DiPentima A,Trucco A,Zizza P,Mariggiò S,Pulvirenti T,Sallese M,Tete S,Mironov AA,Leslie CC,Corda D,Luini A,Polishchuk RS

更新日期：2009-09-01 00:00:00

abstract：:Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular...

journal_title：PLoS biology

authors： Calleja V,Laguerre M,Parker PJ,Larijani B

更新日期：2009-01-20 00:00:00

abstract：:There is a widespread concern about the direct and indirect effects of industrial fisheries; this concern is particularly pertinent for so-called "marine protected areas" (MPAs), which should be safeguarded by national and international law. The intertidal flats of the Dutch Wadden Sea are a State Nature Monument and ...

journal_title：PLoS biology

authors： van Gils JA,Piersma T,Dekinga A,Spaans B,Kraan C

更新日期：2006-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...

journal_title：PLoS biology

authors： Herzig Y,Sharpe HJ,Elbaz Y,Munro S,Schuldiner M

更新日期：2012-01-01 00:00:00

abstract：:Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evidence also suggests that chromosomes may be specifically positioned wi...

journal_title：PLoS biology

authors： Kosak ST,Scalzo D,Alworth SV,Li F,Palmer S,Enver T,Lee JS,Groudine M

更新日期：2007-11-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response. Here, we make the case for how properties of the parasites themselves can also matter. Specifically...

journal_title：PLoS biology

authors： Duneau D,Ebert D

更新日期：2012-01-01 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:How should funding agencies enable researchers to explore high-risk but potentially high-reward science? One model that appears to work is the NSF-funded synthesis center, an incubator for community-led, innovative science. ...

journal_title：PLoS biology

authors： Rodrigo A,Alberts S,Cranston K,Kingsolver J,Lapp H,McClain C,Smith R,Vision T,Weintraub J,Wiegmann B

更新日期：2013-01-01 00:00:00

abstract：:Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begi...

journal_title：PLoS biology

authors： Chevin LM,Lande R,Mace GM

更新日期：2010-04-27 00:00:00

abstract：:When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...

journal_title：PLoS biology

authors： Bays PM,Flanagan JR,Wolpert DM

更新日期：2006-02-01 00:00:00

abstract：:The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent progress in unraveling the role of STIM2 in Ca2+ signaling, the mechan...

journal_title：PLoS biology

authors： Zheng S,Ma G,He L,Zhang T,Li J,Yuan X,Nguyen NT,Huang Y,Zhang X,Gao P,Nwokonko R,Gill DL,Dong H,Zhou Y,Wang Y

更新日期：2018-11-16 00:00:00

abstract：:Over the past 3 decades, in a series of studies on some of the most extensively studied toxic chemicals and pollutants, scientists have found that the amount of toxic chemical linked with the development of a disease or death-which is central to determining "safe" or "hazardous" levels-is proportionately greater at th...

journal_title：PLoS biology

authors： Lanphear BP

更新日期：2017-12-19 00:00:00

abstract：:HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the functional conformation of the HAP2 fusion loo...

journal_title：PLoS biology

authors： Fedry J,Forcina J,Legrand P,Péhau-Arnaudet G,Haouz A,Johnson M,Rey FA,Krey T

更新日期：2018-08-13 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...

journal_title：PLoS biology

authors： Poczai P,Bell N,Hyvönen J

更新日期：2014-01-01 00:00:00

abstract：:Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...

journal_title：PLoS biology

authors： Korkaya H,Paulson A,Charafe-Jauffret E,Ginestier C,Brown M,Dutcher J,Clouthier SG,Wicha MS

更新日期：2009-06-02 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2002794.]. ...

journal_title：PLoS biology

authors： Obleser J,Henry MJ,Lakatos P

更新日期：2017-11-01 00:00:00

abstract：:The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...

journal_title：PLoS biology

authors： Avila I,Lin SC

更新日期：2014-03-18 00:00:00

abstract：:Temporarily holding information in mind is an important part of many cognitive processes, such as reasoning and language. The amount of information that can be actively held "in mind" at any time is greatly limited-research suggests that we can only actively hold three or four pieces of information at once. A central ...

journal_title：PLoS biology

authors： Hakim N,Vogel EK

更新日期：2018-08-29 00:00:00

abstract：:Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

journal_title：PLoS biology

authors： Denk W,Horstmann H

更新日期：2004-11-01 00:00:00