Imre Festetics and the Sheep Breeders' Society of Moravia: Mendel's Forgotten "Research Network".

abstract：:Meta-research is the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives. Given that science is the key driver of human progress, improving the efficiency of scientific investigation and yielding more credible and more useful research results can translate to major benefits. T...

journal_title：PLoS biology

authors： Ioannidis JPA

更新日期：2018-03-13 00:00:00

abstract：:In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate m...

journal_title：PLoS biology

authors： Kaminski Strauss S,Schirman D,Jona G,Brooks AN,Kunjapur AM,Nguyen Ba AN,Flint A,Solt A,Mershin A,Dixit A,Yona AH,Csörgő B,Busby BP,Hennig BP,Pál C,Schraivogel D,Schultz D,Wernick DG,Agashe D,Levi D,Zabezhinsky D,

更新日期：2019-03-29 00:00:00

abstract：:Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...

journal_title：PLoS biology

authors： Colón-Thillet R,Hsieh E,Graf L,McLaughlin RN Jr,Young JM,Kochs G,Emerman M,Malik HS

更新日期：2019-10-01 00:00:00

abstract：:Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS1...

journal_title：PLoS biology

authors： Cao Y,Xu H,Zhu Y,Shi MJ,Wei L,Zhang J,Cheng S,Shi Y,Tong H,Kang L,Lu L,Luo H,Yang X,Bai X,Wang R,Ma Y,Wang Y,Wang Z,Zhong K,Zhao BQ,Fan W

更新日期：2019-06-11 00:00:00

abstract：:Invariant representations of stimulus features are thought to play an important role in producing stable percepts of objects. In the present study, we assess the invariance of neural representations of tactile motion direction with respect to other stimulus properties. To this end, we record the responses evoked in in...

journal_title：PLoS biology

authors： Pei YC,Hsiao SS,Craig JC,Bensmaia SJ

更新日期：2010-02-02 00:00:00

abstract：:PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...

journal_title：PLoS biology

authors： Raia P,Carroni M,Henry E,Pehau-Arnaudet G,Brûlé S,Béguin P,Henneke G,Lindahl E,Delarue M,Sauguet L

更新日期：2019-01-18 00:00:00

abstract：:Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have und...

journal_title：PLoS biology

authors： Rea SL,Ventura N,Johnson TE

更新日期：2007-10-02 00:00:00

abstract：:Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas...

journal_title：PLoS biology

authors： Miller WL,Auchus RJ

更新日期：2019-04-03 00:00:00

abstract：:Rapidly grouping local elements into an organized object (i.e., perceptual integration) is a fundamental yet challenging task, especially in noisy contexts. Previous studies demonstrate that ventral visual pathway, which is widely known to mediate object recognition, engages in the process by conveying object-level in...

journal_title：PLoS biology

authors： Liu L,Wang F,Zhou K,Ding N,Luo H

更新日期：2017-11-30 00:00:00

abstract：:Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...

journal_title：PLoS biology

authors： Yoshii T,Ahmad M,Helfrich-Förster C

更新日期：2009-04-07 00:00:00

abstract：:Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...

journal_title：PLoS biology

authors： Zhang X,Alexander N,Leonardi I,Mason C,Kirkman LA,Deitsch KW

更新日期：2019-05-13 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2006145.]. ...

journal_title：PLoS biology

authors： Saran AR,Kalinowska D,Oh S,Janknecht R,DiTacchio L

更新日期：2019-08-21 00:00:00

abstract：:The ability to find and consume nutrient-rich diets for successful reproduction and survival is fundamental to animal life. Among the nutrients important for all animals are polyamines, a class of pungent smelling compounds required in numerous cellular and organismic processes. Polyamine deficiency or excess has detr...

journal_title：PLoS biology

authors： Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

更新日期：2016-05-04 00:00:00

abstract：:Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the ...

journal_title：PLoS biology

authors： Rujano MA,Bosveld F,Salomons FA,Dijk F,van Waarde MA,van der Want JJ,de Vos RA,Brunt ER,Sibon OC,Kampinga HH

更新日期：2006-12-01 00:00:00

abstract：:The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...

journal_title：PLoS biology

authors： Bossuyt W,De Geest N,Aerts S,Leenaerts I,Marynen P,Hassan BA

更新日期：2009-02-24 00:00:00

abstract：:The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...

journal_title：PLoS biology

authors： Ma S,Kwon HJ,Johng H,Zang K,Huang Z

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrat...

journal_title：PLoS biology

authors： Ryu SW,Stewart R,Pectol DC,Ender NA,Wimalarathne O,Lee JH,Zanini CP,Harvey A,Huibregtse JM,Mueller P,Paull TT

更新日期：2020-07-20 00:00:00

abstract：:Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost in cells using the alternative lengthening of telomeres (ALT) pathway, but it is not known how ATRX loss leads to ALT. We report that ATRX deletion from mouse c...

journal_title：PLoS biology

authors： Lovejoy CA,Takai K,Huh MS,Picketts DJ,de Lange T

更新日期：2020-01-02 00:00:00

abstract：:Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse model of pancreatic islet cell tumorigenesis can be used to meas...

journal_title：PLoS biology

authors： Du YC,Lewis BC,Hanahan D,Varmus H

更新日期：2007-10-16 00:00:00

abstract：:Previously it was shown that male mice, when they encounter female mice or their pheromones, emit ultrasonic vocalizations with frequencies ranging over 30-110 kHz. Here, we show that these vocalizations have the characteristics of song, consisting of several different syllable types, whose temporal sequencing include...

journal_title：PLoS biology

authors： Holy TE,Guo Z

更新日期：2005-12-01 00:00:00

abstract：:Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...

journal_title：PLoS biology

authors： Arnoldini M,Vizcarra IA,Peña-Miller R,Stocker N,Diard M,Vogel V,Beardmore RE,Hardt WD,Ackermann M

更新日期：2014-08-19 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begi...

journal_title：PLoS biology

authors： Chevin LM,Lande R,Mace GM

更新日期：2010-04-27 00:00:00

abstract：:In fungi, mating between partners depends on the molecular recognition of two peptidyl mating pheromones by their respective receptors. The fission yeast Schizosaccharomyces pombe (Sp) has two mating types, Plus (P) and Minus (M). The mating pheromones P-factor and M-factor, secreted by P and M cells, are recognized b...

journal_title：PLoS biology

authors： Seike T,Shimoda C,Niki H

更新日期：2019-01-22 00:00:00

abstract：:Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

journal_title：PLoS biology

authors： Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

更新日期：2008-12-23 00:00:00

abstract：:Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned. Here we identified and validated that clinical placebo response is predictable from resting-state functional magnetic-resonance-imaging (fMRI) brain co...

journal_title：PLoS biology

authors： Tétreault P,Mansour A,Vachon-Presseau E,Schnitzer TJ,Apkarian AV,Baliki MN

更新日期：2016-10-27 00:00:00

abstract：:Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...

journal_title：PLoS biology

authors： Hock K,Wolff NH,Ortiz JC,Condie SA,Anthony KRN,Blackwell PG,Mumby PJ

更新日期：2017-11-28 00:00:00

abstract：:This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing. ...

journal_title：PLoS biology

authors： Wittkopp PJ

更新日期：2010-03-23 00:00:00