Correction: dynamic endothelial cell rearrangements drive developmental vessel regression.

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a framework for underst...

journal_title：PLoS biology

authors： Gao Z,Wyman MJ,Sella G,Przeworski M

更新日期：2016-01-13 00:00:00

abstract：:The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...

journal_title：PLoS biology

authors： Abascal F,Posada D,Knight RD,Zardoya R

更新日期：2006-05-01 00:00:00

abstract：:Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...

journal_title：PLoS biology

authors： Sharp NP,Agrawal AF

更新日期：2016-03-25 00:00:00

abstract：:The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a plateau. Using experimental evolution with bacteriophage, we show here that the converse is also true. In populations small e...

journal_title：PLoS biology

authors： Silander OK,Tenaillon O,Chao L

更新日期：2007-04-01 00:00:00

abstract：:In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate m...

journal_title：PLoS biology

authors： Kaminski Strauss S,Schirman D,Jona G,Brooks AN,Kunjapur AM,Nguyen Ba AN,Flint A,Solt A,Mershin A,Dixit A,Yona AH,Csörgő B,Busby BP,Hennig BP,Pál C,Schraivogel D,Schultz D,Wernick DG,Agashe D,Levi D,Zabezhinsky D,

更新日期：2019-03-29 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...

journal_title：PLoS biology

authors： Palazzo AF,Springer M,Shibata Y,Lee CS,Dias AP,Rapoport TA

更新日期：2007-12-01 00:00:00

abstract：:Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine...

journal_title：PLoS biology

authors： Geissmann Q,Garcia Rodriguez L,Beckwith EJ,French AS,Jamasb AR,Gilestro GF

更新日期：2017-10-19 00:00:00

abstract：:Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to determine whether gene flow would be facilitated or hampered following ...

journal_title：PLoS biology

authors： Ono J,Gerstein AC,Otto SP

更新日期：2017-01-23 00:00:00

abstract：:Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...

journal_title：PLoS biology

authors： Tonkin-Hill GQ,Trianty L,Noviyanti R,Nguyen HHT,Sebayang BF,Lampah DA,Marfurt J,Cobbold SA,Rambhatla JS,McConville MJ,Rogerson SJ,Brown GV,Day KP,Price RN,Anstey NM,Papenfuss AT,Duffy MF

更新日期：2018-03-12 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...

journal_title：PLoS biology

authors： Lu W,Hu Y,Chen G,Chen Z,Zhang H,Wang F,Feng L,Pelicano H,Wang H,Keating MJ,Liu J,McKeehan W,Wang H,Luo Y,Huang P

更新日期：2017-12-11 00:00:00

abstract：:The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...

journal_title：PLoS biology

authors： Yang C,Naya Y

更新日期：2020-11-18 00:00:00

abstract：:PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...

journal_title：PLoS biology

authors： Fiorini N,Canese K,Starchenko G,Kireev E,Kim W,Miller V,Osipov M,Kholodov M,Ismagilov R,Mohan S,Ostell J,Lu Z

更新日期：2018-08-28 00:00:00

abstract：:Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the activation of self-reactive B cells; however, the mechanism underlying the negative regulation of ...

journal_title：PLoS biology

authors： Liu C,Bai X,Wu J,Sharma S,Upadhyaya A,Dahlberg CI,Westerberg LS,Snapper SB,Zhao X,Song W

更新日期：2013-11-01 00:00:00

abstract：:The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...

journal_title：PLoS biology

authors： Ma S,Kwon HJ,Johng H,Zang K,Huang Z

更新日期：2013-01-01 00:00:00

abstract：:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...

journal_title：PLoS biology

authors： Maletic-Savatic M

更新日期：2017-05-15 00:00:00

abstract：:A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...

journal_title：PLoS biology

authors： Bahramisharif A,Jensen O,Jacobs J,Lisman J

更新日期：2018-08-15 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Invariant representations of stimulus features are thought to play an important role in producing stable percepts of objects. In the present study, we assess the invariance of neural representations of tactile motion direction with respect to other stimulus properties. To this end, we record the responses evoked in in...

journal_title：PLoS biology

authors： Pei YC,Hsiao SS,Craig JC,Bensmaia SJ

更新日期：2010-02-02 00:00:00

abstract：:The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

journal_title：PLoS biology

authors： Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

更新日期：2003-12-01 00:00:00

abstract：:The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated wh...

journal_title：PLoS biology

authors： Menacho-Márquez M,García-Escudero R,Ojeda V,Abad A,Delgado P,Costa C,Ruiz S,Alarcón B,Paramio JM,Bustelo XR

更新日期：2013-07-01 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:Every year, ovarian cancer kills approximately 14,000 women in the United States and more than 140,000 women worldwide. Most of these deaths are caused by tumors of the serous histological type, which is rarely diagnosed before it has disseminated. By deep paired-end sequencing of mRNA from serous ovarian cancers, fol...

journal_title：PLoS biology

authors： Salzman J,Marinelli RJ,Wang PL,Green AE,Nielsen JS,Nelson BH,Drescher CW,Brown PO

更新日期：2011-09-01 00:00:00

abstract：:The organization and the mechanisms of condensation of mitotic chromosomes remain unsolved despite many decades of efforts. The lack of resolution, tight compaction, and the absence of function-specific chromatin labels have been the key technical obstacles. The correlation between DNA sequence composition and its con...

journal_title：PLoS biology

authors： Strukov YG,Sural TH,Kuroda MI,Sedat JW

更新日期：2011-01-11 00:00:00

abstract：:Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a critical regulator o...

journal_title：PLoS biology

authors： Zhang X,Chen W,Gao Q,Yang J,Yan X,Zhao H,Su L,Yang M,Gao C,Yao Y,Inoki K,Li D,Shao R,Wang S,Sahoo N,Kudo F,Eguchi T,Ruan B,Xu H

更新日期：2019-05-21 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated. Here we show that ...

journal_title：PLoS biology

authors： Baldini F,Gabrieli P,South A,Valim C,Mancini F,Catteruccia F

更新日期：2013-10-01 00:00:00

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00