A question of fate.

Abstract:

:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over the past decade, many researchers have contributed to characterizing these cells and their lineages, providing the foundation for their utilization as therapeutic devices. In a new study, Azim and colleagues took a different approach: using pharmacogenomics to focus on neural stem cell lineage, they identified specific compounds that can direct neural stem cell fate toward a specific lineage in vivo, both in physiological and pathological conditions. Their work opens new avenues for treatment of neurodegenerative and demyelinating disorders.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Maletic-Savatic M

doi

10.1371/journal.pbio.2002329

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

e2002329

issue

5

eissn

1544-9173

issn

1545-7885

pii

pbio.2002329

journal_volume

15

pub_type

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