Abstract:
:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over the past decade, many researchers have contributed to characterizing these cells and their lineages, providing the foundation for their utilization as therapeutic devices. In a new study, Azim and colleagues took a different approach: using pharmacogenomics to focus on neural stem cell lineage, they identified specific compounds that can direct neural stem cell fate toward a specific lineage in vivo, both in physiological and pathological conditions. Their work opens new avenues for treatment of neurodegenerative and demyelinating disorders.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Maletic-Savatic Mdoi
10.1371/journal.pbio.2002329subject
Has Abstractpub_date
2017-05-15 00:00:00pages
e2002329issue
5eissn
1544-9173issn
1545-7885pii
pbio.2002329journal_volume
15pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::The ecologically significant shift in developmental strategy from planktotrophic (feeding) to lecithotrophic (nonfeeding) development in the sea urchin genus Heliocidaris is one of the most comprehensively studied life history transitions in any animal. Although the evolution of lecithotrophy involved substantial chan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002391
更新日期:2016-03-04 00:00:00
abstract::The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000194
更新日期:2009-09-01 00:00:00
abstract::Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1002477
更新日期:2016-06-14 00:00:00
abstract::The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrat...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000606
更新日期:2020-07-20 00:00:00
abstract::The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020203
更新日期:2004-08-01 00:00:00
abstract::The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000102
更新日期:2009-05-01 00:00:00
abstract::The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001811
更新日期:2014-03-18 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2002794.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002615
更新日期:2017-11-01 00:00:00
abstract::Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004328
更新日期:2018-03-12 00:00:00
abstract::A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005952
更新日期:2018-11-01 00:00:00
abstract::One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejecte...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001422
更新日期:2012-01-01 00:00:00
abstract::Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. However, recent preclinical and clinical observations of tumor initiati...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000399
更新日期:2019-08-05 00:00:00
abstract::Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002419
更新日期:2016-03-25 00:00:00
abstract::The MooSciTIC project is a capacity-building initiative targeting West African research scientists and higher education teachers. The project aimed to improve the self-reliance of researchers and upgrade research practices by providing on-site summer schools on trans-disciplinary topics such as scientific writing, com...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000312
更新日期:2019-06-07 00:00:00
abstract::Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000249
更新日期:2009-11-01 00:00:00
abstract::Progress in science often begins with verbal hypotheses meant to explain why certain biological phenomena exist. An important purpose of mathematical models in evolutionary research, as in many other fields, is to act as “proof-of-concept” tests of the logic in verbal explanations, paralleling the way in which empiric...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002017
更新日期:2014-12-09 00:00:00
abstract::Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000493
更新日期:2010-09-28 00:00:00
abstract::As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexpression in females ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001328
更新日期:2012-01-01 00:00:00
abstract::In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002083
更新日期:2015-02-24 00:00:00
abstract::Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001655
更新日期:2017-09-13 00:00:00
abstract::When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...
journal_title:PLoS biology
pub_type: 临床试验,杂志文章
doi:10.1371/journal.pbio.0040028
更新日期:2006-02-01 00:00:00
abstract::The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmental organization of the vertebrate central nervous system. In the hindbrain and spinal cord, distinctions in the rostrocaudal identity of progenitor cells are associated with the generation of ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040252
更新日期:2006-07-01 00:00:00
abstract::The segmentation gene network of Drosophila consists of maternal and zygotic factors that generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity along the anterior-posterior axis of the embryo. Using known binding site information for maternal and zygotic gap transcription facto...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020271
更新日期:2004-09-01 00:00:00
abstract::Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalam...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001112
更新日期:2011-07-01 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002619
更新日期:2018-01-25 00:00:00
abstract::Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding mo...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1001893
更新日期:2014-06-24 00:00:00
abstract::Over the last decades, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and behavior. This arduous work has yielded results with far-reaching consequences in metabolic, psychiatric, and neoplastic disorders. Recent attempts to expand our understanding of circadian regulation...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001840
更新日期:2014-04-15 00:00:00
abstract::Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated wit...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020296
更新日期:2004-09-01 00:00:00
abstract::With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena. The genetics of transcriptional regulation and protein abundance are likely to be complex, meaning that genetic variation at multiple loci will infl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030267
更新日期:2005-08-01 00:00:00
abstract::Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001170
更新日期:2011-10-01 00:00:00