Abstract:
:Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begin to understand the limits to population persistence, we present a simple evolutionary model for the critical rate of environmental change beyond which a population must decline and go extinct. We use this model to highlight the major determinants of extinction risk in a changing environment, and identify research needs for improved predictions based on projected changes in environmental variables. Two key parameters relating the environment to population biology have not yet received sufficient attention. Phenotypic plasticity, the direct influence of environment on the development of individual phenotypes, is increasingly considered an important component of phenotypic change in the wild and should be incorporated in models of population persistence. Environmental sensitivity of selection, the change in the optimum phenotype with the environment, still crucially needs empirical assessment. We use environmental tolerance curves and other examples of ecological and evolutionary responses to climate change to illustrate how these mechanistic approaches can be developed for predictive purposes.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Chevin LM,Lande R,Mace GMdoi
10.1371/journal.pbio.1000357subject
Has Abstractpub_date
2010-04-27 00:00:00pages
e1000357issue
4eissn
1544-9173issn
1545-7885journal_volume
8pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000040
更新日期:2009-02-24 00:00:00
abstract::The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men....
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000285
更新日期:2010-01-19 00:00:00
abstract::Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to the relatively well-defined shape of bacteria and yeast c...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000542
更新日期:2010-11-16 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2006145.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.3000454
更新日期:2019-08-21 00:00:00
abstract::The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP hydrolysis. When filaments form on duplex DNA, RecA protein exhibits a fu...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030052
更新日期:2005-02-01 00:00:00
abstract::The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001623
更新日期:2013-01-01 00:00:00
abstract::Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. These pathological fea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001008
更新日期:2020-12-14 00:00:00
abstract::How often do people visit the world's protected areas (PAs)? Despite PAs covering one-eighth of the land and being a major focus of nature-based recreation and tourism, we don't know. To address this, we compiled a globally-representative database of visits to PAs and built region-specific models predicting visit rate...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002074
更新日期:2015-02-24 00:00:00
abstract::Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic treatment remains u...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002810
更新日期:2017-11-06 00:00:00
abstract::The ability to find and consume nutrient-rich diets for successful reproduction and survival is fundamental to animal life. Among the nutrients important for all animals are polyamines, a class of pungent smelling compounds required in numerous cellular and organismic processes. Polyamine deficiency or excess has detr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002454
更新日期:2016-05-04 00:00:00
abstract::Citizen science is mainstream: millions of people contribute data to a growing array of citizen science projects annually, forming massive datasets that will drive research for years to come. Many citizen science projects implement a "leaderboard" framework, ranking the contributions based on number of records or spec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000357
更新日期:2019-06-27 00:00:00
abstract::Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000121
更新日期:2009-06-02 00:00:00
abstract::G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000434
更新日期:2019-11-25 00:00:00
abstract::The cerebellum has been proposed to be a crucial component in the state estimation process that combines information from motor efferent and sensory afferent signals to produce a representation of the current state of the motor system. Such a state estimate of the moving human arm would be expected to be used when the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050316
更新日期:2007-11-01 00:00:00
abstract::Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040112
更新日期:2006-05-01 00:00:00
abstract::Despite many prior studies demonstrating offline behavioral gains in motor skills after sleep, the underlying neural mechanisms remain poorly understood. To investigate the neurophysiological basis for offline gains, we performed single-unit recordings in motor cortex as rats learned a skilled upper-limb task. We foun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002263
更新日期:2015-09-18 00:00:00
abstract::The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a phase of massive growth and concomitant patterning during larval s...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001182
更新日期:2011-10-01 00:00:00
abstract::The human gut harbours a large and genetically diverse population of symbiotic microbes that both feed and protect the host. Evolutionary theory, however, predicts that such genetic diversity can destabilise mutualistic partnerships. How then can the mutualism of the human microbiota be explained? Here we develop an i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001424
更新日期:2012-01-01 00:00:00
abstract::In nature, Escherichia coli are exposed to harsh and non-ideal growth environments-nutrients may be limiting, and cells are often challenged by oxidative stress. For E. coli cells confronting these realities, there appears to be a link between oxidative stress, methionine availability, and the enzyme that catalyzes th...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020336
更新日期:2004-11-01 00:00:00
abstract::Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 sin...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000451
更新日期:2010-08-10 00:00:00
abstract::Zinc is an essential mineral, but our understanding of its uses in the body is limited. Capitalizing on approaches available in the model system Caenorhabditis elegans, Zhao and colleagues show that zinc transduces a signal that induces sperm to become motile. This is an enigmatic process because sperm in all sexually...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006204
更新日期:2018-06-07 00:00:00
abstract::Courtship is a widespread behavior in which one gender conveys to the other a series of cues about their species identity, gender, and suitability as mates. In many species, females decode these male displays and either accept or reject them. Despite the fact that courtship has been investigated for a long time, the g...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001964
更新日期:2014-10-07 00:00:00
abstract::Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000198
更新日期:2019-04-03 00:00:00
abstract::Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000181
更新日期:2019-10-01 00:00:00
abstract::Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001928
更新日期:2014-08-19 00:00:00
abstract::FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001389
更新日期:2012-01-01 00:00:00
abstract::Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000086
更新日期:2009-04-07 00:00:00
abstract::PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000122
更新日期:2019-01-18 00:00:00
abstract::The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understandi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002811
更新日期:2018-01-18 00:00:00
abstract::Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have designed synthetic "s...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000328
更新日期:2019-06-17 00:00:00