Zinc: A small molecule with a big impact on sperm function.

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp. p45/NRH2/PLAIDD is a p75 homologue and contains a death domain (DD). Here we report th...

journal_title：PLoS biology

authors： Vilar M,Sung TC,Chen Z,García-Carpio I,Fernandez EM,Xu J,Riek R,Lee KF

更新日期：2014-08-05 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...

journal_title：PLoS biology

authors： Fatsis-Kavalopoulos N,Roemhild R,Tang PC,Kreuger J,Andersson DI

更新日期：2020-09-17 00:00:00

abstract：:A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly ...

journal_title：PLoS biology

authors： Shirangi TR,Dufour HD,Williams TM,Carroll SB

更新日期：2009-08-01 00:00:00

abstract：:PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...

journal_title：PLoS biology

authors： Fiorini N,Canese K,Starchenko G,Kireev E,Kim W,Miller V,Osipov M,Kholodov M,Ismagilov R,Mohan S,Ostell J,Lu Z

更新日期：2018-08-28 00:00:00

abstract：:Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...

journal_title：PLoS biology

authors： Krylova O,Earn DJD

更新日期：2020-12-21 00:00:00

abstract：:A large repertoire of natural object manipulation tasks require precisely coupled symmetrical opposing forces by both hands on a single object. We asked how the lateralized brain handles this basic problem of spatial and temporal coordination. We show that the brain consistently appoints one of the hands as prime acto...

journal_title：PLoS biology

authors： Johansson RS,Theorin A,Westling G,Andersson M,Ohki Y,Nyberg L

更新日期：2006-06-01 00:00:00

abstract：:Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...

journal_title：PLoS biology

authors： André V,Gau C,Scheideler A,Aguilar-Pimentel JA,Amarie OV,Becker L,Garrett L,Hans W,Hölter SM,Janik D,Moreth K,Neff F,Östereicher M,Racz I,Rathkolb B,Rozman J,Bekeredjian R,Graw J,Klingenspor M,Klopstock T,Ollert M

更新日期：2018-04-16 00:00:00

abstract：:A lysosomal storage disease (LSD) results from deficient lysosomal enzyme activity, thus the substrate of the mutant enzyme accumulates in the lysosome, leading to pathology. In many but not all LSDs, the clinically most important mutations compromise the cellular folding of the enzyme, subjecting it to endoplasmic re...

journal_title：PLoS biology

authors： Mu TW,Fowler DM,Kelly JW

更新日期：2008-02-01 00:00:00

abstract：:The transcription rate of a gene is often controlled by several regulators that bind specific sites in the gene's cis-regulatory region. The combined effect of these regulators is described by a cis-regulatory input function. What determines the form of an input function, and how variable is it with respect to mutatio...

journal_title：PLoS biology

authors： Mayo AE,Setty Y,Shavit S,Zaslaver A,Alon U

更新日期：2006-04-01 00:00:00

abstract：:In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time. ...

journal_title：PLoS biology

authors： Pariente N,PLOS Biology Staff Editors.

更新日期：2020-10-22 00:00:00

abstract：:Over the past two decades, neuroscientists have increasingly turned their attention to the question of how the brain implements decisions between differently valued options. This emerging field, called neuroeconomics, has made quick progress in identifying a plethora of brain areas that track or are modulated by rewar...

journal_title：PLoS biology

authors： Stott JJ,Redish AD

更新日期：2015-06-18 00:00:00

abstract：:Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling ...

journal_title：PLoS biology

authors： Lau KS,Cortez-Retamozo V,Philips SR,Pittet MJ,Lauffenburger DA,Haigis KM

更新日期：2012-01-01 00:00:00

abstract：:Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to iden...

journal_title：PLoS biology

authors： Riethmueller S,Somasundaram P,Ehlers JC,Hung CW,Flynn CM,Lokau J,Agthe M,Düsterhöft S,Zhu Y,Grötzinger J,Lorenzen I,Koudelka T,Yamamoto K,Pickhinke U,Wichert R,Becker-Pauly C,Rädisch M,Albrecht A,Hessefort M,Stahnke

更新日期：2017-01-06 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...

journal_title：PLoS biology

authors： Poczai P,Bell N,Hyvönen J

更新日期：2014-01-01 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to th...

journal_title：PLoS biology

authors： Simmer F,Moorman C,van der Linden AM,Kuijk E,van den Berghe PV,Kamath RS,Fraser AG,Ahringer J,Plasterk RH

更新日期：2003-10-01 00:00:00

abstract：:The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated wh...

journal_title：PLoS biology

authors： Menacho-Márquez M,García-Escudero R,Ojeda V,Abad A,Delgado P,Costa C,Ruiz S,Alarcón B,Paramio JM,Bustelo XR

更新日期：2013-07-01 00:00:00

abstract：:The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor (D1R)- and D2 dopamine receptor (D2R)-expressing medium spiny neurons (MSNs). How various neurotransmitter inputs converging on common intracellular pathways are p...

journal_title：PLoS biology

authors： Sutton LP,Muntean BS,Ostrovskaya O,Zucca S,Dao M,Orlandi C,Song C,Xie K,Martemyanov KA

更新日期：2019-10-10 00:00:00

abstract：:During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kin...

journal_title：PLoS biology

authors： Loc'h J,Blaud M,Réty S,Lebaron S,Deschamps P,Bareille J,Jombart J,Robert-Paganin J,Delbos L,Chardon F,Zhang E,Charenton C,Tollervey D,Leulliot N

更新日期：2014-05-13 00:00:00

abstract：:Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...

journal_title：PLoS biology

authors： Leitão-Gonçalves R,Carvalho-Santos Z,Francisco AP,Fioreze GT,Anjos M,Baltazar C,Elias AP,Itskov PM,Piper MDW,Ribeiro C

更新日期：2017-04-25 00:00:00

abstract：:Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm for the generation of vascularized organoids (vOrganoids) consis...

journal_title：PLoS biology

authors： Shi Y,Sun L,Wang M,Liu J,Zhong S,Li R,Li P,Guo L,Fang A,Chen R,Ge WP,Wu Q,Wang X

更新日期：2020-05-13 00:00:00

abstract：:Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges. Here we show that natural primary immune responses against parasites generate bifun...

journal_title：PLoS biology

authors： Peine M,Rausch S,Helmstetter C,Fröhlich A,Hegazy AN,Kühl AA,Grevelding CG,Höfer T,Hartmann S,Löhning M

更新日期：2013-01-01 00:00:00

abstract：:Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...

journal_title：PLoS biology

authors： Hernandez-Sanchez W,Huang W,Plucinsky B,Garcia-Vazquez N,Robinson NJ,Schiemann WP,Berdis AJ,Skordalakes E,Taylor DJ

更新日期：2019-04-05 00:00:00

abstract：:Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...

journal_title：PLoS biology

authors： Valdés-Baizabal C,Carbajal GV,Pérez-González D,Malmierca MS

更新日期：2020-06-19 00:00:00

abstract：:The MooSciTIC project is a capacity-building initiative targeting West African research scientists and higher education teachers. The project aimed to improve the self-reliance of researchers and upgrade research practices by providing on-site summer schools on trans-disciplinary topics such as scientific writing, com...

journal_title：PLoS biology

authors： Atindehou M,Adéoti K,Loko LEY,Beulé T,Paradis E,Djedatin G,Tranchant-Dubreuil C,Sabot F,Lagnika L,Jaligot E

更新日期：2019-06-07 00:00:00

abstract：:Synaptic plasticity is widely believed to constitute a key mechanism for modifying functional properties of neuronal networks. This belief implicitly implies, however, that synapses, when not driven to change their characteristics by physiologically relevant stimuli, will maintain these characteristics over time. How ...

journal_title：PLoS biology

authors： Minerbi A,Kahana R,Goldfeld L,Kaufman M,Marom S,Ziv NE

更新日期：2009-06-23 00:00:00