A predominantly neolithic origin for European paternal lineages.

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00

abstract：:Recently, prominent theoretical linguists have argued for an explicit scenario for the evolution of the human language capacity on the basis of its computational properties. Concretely, the simplicity of a minimalist formulation of the operation Merge, which allows humans to recursively compute hierarchical relations ...

journal_title：PLoS biology

authors： Martins PT,Boeckx C

更新日期：2019-11-27 00:00:00

abstract：:Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...

journal_title：PLoS biology

authors： Sharp NP,Agrawal AF

更新日期：2016-03-25 00:00:00

abstract：:Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient o...

journal_title：PLoS biology

authors： Chen Y,Keskin D,Sugimoto H,Kanasaki K,Phillips PE,Bizarro L,Sharpe A,LeBleu VS,Kalluri R

更新日期：2018-12-28 00:00:00

abstract：:Despite many prior studies demonstrating offline behavioral gains in motor skills after sleep, the underlying neural mechanisms remain poorly understood. To investigate the neurophysiological basis for offline gains, we performed single-unit recordings in motor cortex as rats learned a skilled upper-limb task. We foun...

journal_title：PLoS biology

authors： Ramanathan DS,Gulati T,Ganguly K

更新日期：2015-09-18 00:00:00

abstract：:DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not known how they disrupt RNA tertiary structure. Here, we use sing...

journal_title：PLoS biology

authors： Pan C,Potratz JP,Cannon B,Simpson ZB,Ziehr JL,Tijerina P,Russell R

更新日期：2014-10-28 00:00:00

abstract：:Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...

journal_title：PLoS biology

authors： Augustin H,McGourty K,Allen MJ,Madem SK,Adcott J,Kerr F,Wong CT,Vincent A,Godenschwege T,Boucrot E,Partridge L

更新日期：2017-09-13 00:00:00

abstract：:Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The female-specific neo-W chromosome of the African monarch (or queen) butterfly Danaus chrysippus presents an intriguing case study because it is restricted to a single 'contact zone' population, invol...

journal_title：PLoS biology

authors： Martin SH,Singh KS,Gordon IJ,Omufwoko KS,Collins S,Warren IA,Munby H,Brattström O,Traut W,Martins DJ,Smith DAS,Jiggins CD,Bass C,Ffrench-Constant RH

更新日期：2020-02-27 00:00:00

abstract：:Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...

journal_title：PLoS biology

authors： Moore JD,Mercer Lindsay N,Deschênes M,Kleinfeld D

更新日期：2015-09-22 00:00:00

abstract：:Courtship is a widespread behavior in which one gender conveys to the other a series of cues about their species identity, gender, and suitability as mates. In many species, females decode these male displays and either accept or reject them. Despite the fact that courtship has been investigated for a long time, the g...

journal_title：PLoS biology

authors： Schinaman JM,Giesey RL,Mizutani CM,Lukacsovich T,Sousa-Neves R

更新日期：2014-10-07 00:00:00

abstract：:Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...

journal_title：PLoS biology

authors： Arnoldini M,Vizcarra IA,Peña-Miller R,Stocker N,Diard M,Vogel V,Beardmore RE,Hardt WD,Ackermann M

更新日期：2014-08-19 00:00:00

abstract：:The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmental organization of the vertebrate central nervous system. In the hindbrain and spinal cord, distinctions in the rostrocaudal identity of progenitor cells are associated with the generation of ...

journal_title：PLoS biology

authors： Nordström U,Maier E,Jessell TM,Edlund T

更新日期：2006-07-01 00:00:00

abstract：:In photosynthetic organisms, feedback dissipation of excess absorbed light energy balances harvesting of light with metabolic energy consumption. This mechanism prevents photodamage caused by reactive oxygen species produced by the reaction of chlorophyll (Chl) triplet states with O₂. Plants have been found to perform...

journal_title：PLoS biology

authors： Bonente G,Ballottari M,Truong TB,Morosinotto T,Ahn TK,Fleming GR,Niyogi KK,Bassi R

更新日期：2011-01-18 00:00:00

abstract：:We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

journal_title：PLoS biology

authors： Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

更新日期：2006-03-01 00:00:00

abstract：:The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...

journal_title：PLoS biology

authors： Foley E,O'Farrell PH

更新日期：2004-08-01 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...

journal_title：PLoS biology

authors： André V,Gau C,Scheideler A,Aguilar-Pimentel JA,Amarie OV,Becker L,Garrett L,Hans W,Hölter SM,Janik D,Moreth K,Neff F,Östereicher M,Racz I,Rathkolb B,Rozman J,Bekeredjian R,Graw J,Klingenspor M,Klopstock T,Ollert M

更新日期：2018-04-16 00:00:00

abstract：:The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a uniqu...

journal_title：PLoS biology

authors： Strech D,Weissgerber T,Dirnagl U,QUEST Group.

更新日期：2020-02-11 00:00:00

abstract：:In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response. Here, we make the case for how properties of the parasites themselves can also matter. Specifically...

journal_title：PLoS biology

authors： Duneau D,Ebert D

更新日期：2012-01-01 00:00:00

abstract：:Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PABPC1 is a crucial de...

journal_title：PLoS biology

authors： Eberle AB,Stalder L,Mathys H,Orozco RZ,Mühlemann O

更新日期：2008-04-29 00:00:00

abstract：:Misalignment of the daily sleep-wake and fasting-feeding cycles with the endogenous circadian timing system is an inevitable consequence of night shift work and is associated with adverse metabolic health effects. However, a detailed characterisation of the effects of night shifts on 24-h rhythms in the metabolome is ...

journal_title：PLoS biology

authors： Kervezee L,Cermakian N,Boivin DB

更新日期：2019-06-18 00:00:00

abstract：:The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...

journal_title：PLoS biology

authors： Bossuyt W,De Geest N,Aerts S,Leenaerts I,Marynen P,Hassan BA

更新日期：2009-02-24 00:00:00

abstract：:Both endocrine and exocrine pancreatic cells arise from pancreatic-duodenal homeobox 1 (pdx1)-positive progenitors. The molecular mechanisms controlling cell fate determination and subsequent proliferation, however, are poorly understood. Unlike endocrine cells, less is known about exocrine cell specification. We repo...

journal_title：PLoS biology

authors： Jiang Z,Song J,Qi F,Xiao A,An X,Liu NA,Zhu Z,Zhang B,Lin S

更新日期：2008-11-25 00:00:00

abstract：:Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...

journal_title：PLoS biology

authors： Barbeito-Andrés J,Schuler-Faccini L,Garcez PP

更新日期：2018-08-24 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000311.]. ...

journal_title：PLoS biology

authors： Simeon R,Jiang M,Chamoun-Emanuelli AM,Yu H,Zhang Y,Meng R,Peng Z,Jakana J,Zhang J,Feng H,Chen Z

更新日期：2019-10-04 00:00:00

abstract：:Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...

journal_title：PLoS biology

authors： Kompella P,Gracia B,LeBlanc L,Engelman S,Kulkarni C,Desai N,June V,March S,Pattengale S,Rodriguez-Rivera G,Ryu SW,Strohkendl I,Mandke P,Clark G

更新日期：2020-03-30 00:00:00

abstract：:Temporarily holding information in mind is an important part of many cognitive processes, such as reasoning and language. The amount of information that can be actively held "in mind" at any time is greatly limited-research suggests that we can only actively hold three or four pieces of information at once. A central ...

journal_title：PLoS biology

authors： Hakim N,Vogel EK

更新日期：2018-08-29 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...

journal_title：PLoS biology

authors： Morlon H,Potts MD,Plotkin JB

更新日期：2010-09-28 00:00:00

abstract：:Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a closed conformation. Since closed syntaxin is unable to interact ...

journal_title：PLoS biology

authors： Zilly FE,Sørensen JB,Jahn R,Lang T

更新日期：2006-10-01 00:00:00