Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative.

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...

journal_title：PLoS biology

authors： Abascal F,Posada D,Knight RD,Zardoya R

更新日期：2006-05-01 00:00:00

abstract：:Pheromones form an essential chemical language of intraspecific communication in many animals. How olfactory systems recognize pheromonal signals with both sensitivity and specificity is not well understood. An important in vivo paradigm for this process is the detection mechanism of the sex pheromone (Z)-11-octadecen...

journal_title：PLoS biology

authors： Gomez-Diaz C,Reina JH,Cambillau C,Benton R

更新日期：2013-01-01 00:00:00

abstract：:Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned. Here we identified and validated that clinical placebo response is predictable from resting-state functional magnetic-resonance-imaging (fMRI) brain co...

journal_title：PLoS biology

authors： Tétreault P,Mansour A,Vachon-Presseau E,Schnitzer TJ,Apkarian AV,Baliki MN

更新日期：2016-10-27 00:00:00

abstract：:Global warming is significantly altering arctic marine ecosystems. Specifically, the precipitous loss of sea ice is creating a dichotomy between ice-dependent polar bears and pinnipeds that are losing habitat and some cetaceans that are gaining habitat. While final outcomes are hard to predict for the many and varied ...

journal_title：PLoS biology

authors： Moore SE,Reeves RR

更新日期：2018-10-09 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary selection. Theoretical and experimental analyses of bacterial chemotaxis suggested that the pathway has been evolutionarily optimized to produce robust output u...

journal_title：PLoS biology

authors： Løvdok L,Bentele K,Vladimirov N,Müller A,Pop FS,Lebiedz D,Kollmann M,Sourjik V

更新日期：2009-08-01 00:00:00

abstract：:Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to iden...

journal_title：PLoS biology

authors： Riethmueller S,Somasundaram P,Ehlers JC,Hung CW,Flynn CM,Lokau J,Agthe M,Düsterhöft S,Zhu Y,Grötzinger J,Lorenzen I,Koudelka T,Yamamoto K,Pickhinke U,Wichert R,Becker-Pauly C,Rädisch M,Albrecht A,Hessefort M,Stahnke

更新日期：2017-01-06 00:00:00

abstract：:Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

journal_title：PLoS biology

authors： Varshney RK,Terauchi R,McCouch SR

更新日期：2014-06-10 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:Over the past two decades, neuroscientists have increasingly turned their attention to the question of how the brain implements decisions between differently valued options. This emerging field, called neuroeconomics, has made quick progress in identifying a plethora of brain areas that track or are modulated by rewar...

journal_title：PLoS biology

authors： Stott JJ,Redish AD

更新日期：2015-06-18 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...

journal_title：PLoS biology

authors： Ricard N,Simons M

更新日期：2015-05-15 00:00:00

abstract：:The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...

journal_title：PLoS biology

authors： de Sousa N,Rodríguez-Esteban G,Rojo-Laguna JI,Saló E,Adell T

更新日期：2018-01-22 00:00:00

abstract：:A large repertoire of natural object manipulation tasks require precisely coupled symmetrical opposing forces by both hands on a single object. We asked how the lateralized brain handles this basic problem of spatial and temporal coordination. We show that the brain consistently appoints one of the hands as prime acto...

journal_title：PLoS biology

authors： Johansson RS,Theorin A,Westling G,Andersson M,Ohki Y,Nyberg L

更新日期：2006-06-01 00:00:00

abstract：:Both endocrine and exocrine pancreatic cells arise from pancreatic-duodenal homeobox 1 (pdx1)-positive progenitors. The molecular mechanisms controlling cell fate determination and subsequent proliferation, however, are poorly understood. Unlike endocrine cells, less is known about exocrine cell specification. We repo...

journal_title：PLoS biology

authors： Jiang Z,Song J,Qi F,Xiao A,An X,Liu NA,Zhu Z,Zhang B,Lin S

更新日期：2008-11-25 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:A new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both excitatory and inhibitory synapses in the brain, but by different mechanisms. Read the accompanying Research Article. ...

journal_title：PLoS biology

authors： Robinson R

更新日期：2015-05-21 00:00:00

abstract：:Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the prevalence of phylosymbiosis and its functional significance under highly controlled conditions b...

journal_title：PLoS biology

authors： Brooks AW,Kohl KD,Brucker RM,van Opstal EJ,Bordenstein SR

更新日期：2016-11-18 00:00:00

abstract：:This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing. ...

journal_title：PLoS biology

authors： Wittkopp PJ

更新日期：2010-03-23 00:00:00

abstract：:Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...

journal_title：PLoS biology

authors： Augustin H,McGourty K,Allen MJ,Madem SK,Adcott J,Kerr F,Wong CT,Vincent A,Godenschwege T,Boucrot E,Partridge L

更新日期：2017-09-13 00:00:00

abstract：:Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analys...

journal_title：PLoS biology

authors： McGrath TM,Spreckley E,Rodriguez AF,Viscomi C,Alamshah A,Akalestou E,Murphy KG,Jones NS

更新日期：2019-12-05 00:00:00

abstract：:Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity of opposing kinase signaling complexes has remained elusive. We report...

journal_title：PLoS biology

authors： Merrill RA,Dagda RK,Dickey AS,Cribbs JT,Green SH,Usachev YM,Strack S

更新日期：2011-04-01 00:00:00

abstract：:STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatr...

journal_title：PLoS biology

authors： Xu J,Chatterjee M,Baguley TD,Brouillette J,Kurup P,Ghosh D,Kanyo J,Zhang Y,Seyb K,Ononenyi C,Foscue E,Anderson GM,Gresack J,Cuny GD,Glicksman MA,Greengard P,Lam TT,Tautz L,Nairn AC,Ellman JA,Lombroso PJ

更新日期：2014-08-05 00:00:00

abstract：:Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...

journal_title：PLoS biology

authors： Tonkin-Hill GQ,Trianty L,Noviyanti R,Nguyen HHT,Sebayang BF,Lampah DA,Marfurt J,Cobbold SA,Rambhatla JS,McConville MJ,Rogerson SJ,Brown GV,Day KP,Price RN,Anstey NM,Papenfuss AT,Duffy MF

更新日期：2018-03-12 00:00:00

abstract：:The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies. Cajal bodies are nuclear organelles involved in diverse functions such as processing ribonucleoproteins important for splicing. Here we identify the...

journal_title：PLoS biology

authors： Mahmoudi S,Henriksson S,Weibrecht I,Smith S,Söderberg O,Strömblad S,Wiman KG,Farnebo M

更新日期：2010-11-02 00:00:00

abstract：:The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...

journal_title：PLoS biology

authors： Avila I,Lin SC

更新日期：2014-03-18 00:00:00

abstract：:Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...

journal_title：PLoS biology

authors： Hernandez-Sanchez W,Huang W,Plucinsky B,Garcia-Vazquez N,Robinson NJ,Schiemann WP,Berdis AJ,Skordalakes E,Taylor DJ

更新日期：2019-04-05 00:00:00

abstract：:In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response. Here, we make the case for how properties of the parasites themselves can also matter. Specifically...

journal_title：PLoS biology

authors： Duneau D,Ebert D

更新日期：2012-01-01 00:00:00

abstract：:Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

journal_title：PLoS biology

authors： Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

更新日期：2005-07-01 00:00:00