Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative.

abstract：:The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided...

journal_title：PLoS biology

authors： Waibel M,Floreano D,Keller L

更新日期：2011-05-01 00:00:00

abstract：:Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...

journal_title：PLoS biology

authors： Hock K,Wolff NH,Ortiz JC,Condie SA,Anthony KRN,Blackwell PG,Mumby PJ

更新日期：2017-11-28 00:00:00

abstract：:Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 sin...

journal_title：PLoS biology

authors： Boyko AR,Quignon P,Li L,Schoenebeck JJ,Degenhardt JD,Lohmueller KE,Zhao K,Brisbin A,Parker HG,vonHoldt BM,Cargill M,Auton A,Reynolds A,Elkahloun AG,Castelhano M,Mosher DS,Sutter NB,Johnson GS,Novembre J,Hubisz MJ,

更新日期：2010-08-10 00:00:00

abstract：:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...

journal_title：PLoS biology

authors： Maletic-Savatic M

更新日期：2017-05-15 00:00:00

abstract：:The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understandi...

journal_title：PLoS biology

authors： Murphy AC,Muldoon SF,Baker D,Lastowka A,Bennett B,Yang M,Bassett DS

更新日期：2018-01-18 00:00:00

abstract：:The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...

journal_title：PLoS biology

authors： Yang C,Naya Y

更新日期：2020-11-18 00:00:00

abstract：:Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated wit...

journal_title：PLoS biology

authors： Kaeberlein M,Kirkland KT,Fields S,Kennedy BK

更新日期：2004-09-01 00:00:00

abstract：:The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials ...

journal_title：PLoS biology

authors： Jang J,Han D,Golkaram M,Audouard M,Liu G,Bridges D,Hellander S,Chialastri A,Dey SS,Petzold LR,Kosik KS

更新日期：2019-09-26 00:00:00

abstract：:Although amyloid fibrillation is generally believed to be a nucleation-dependent process, the nuclei are largely structurally uncharacterized. This is in part due to the inherent experimental challenge associated with structural descriptions of individual components in a dynamic multi-component equilibrium. There are ...

journal_title：PLoS biology

authors： Vestergaard B,Groenning M,Roessle M,Kastrup JS,van de Weert M,Flink JM,Frokjaer S,Gajhede M,Svergun DI

更新日期：2007-05-01 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have...

journal_title：PLoS biology

authors： Hershberg R,Lipatov M,Small PM,Sheffer H,Niemann S,Homolka S,Roach JC,Kremer K,Petrov DA,Feldman MW,Gagneux S

更新日期：2008-12-16 00:00:00

abstract：:To elucidate the history of living and extinct elephantids, we generated 39,763 bp of aligned nuclear DNA sequence across 375 loci for African savanna elephant, African forest elephant, Asian elephant, the extinct American mastodon, and the woolly mammoth. Our data establish that the Asian elephant is the closest livi...

journal_title：PLoS biology

authors： Rohland N,Reich D,Mallick S,Meyer M,Green RE,Georgiadis NJ,Roca AL,Hofreiter M

更新日期：2010-12-21 00:00:00

abstract：:Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex I are involved in a wide range of degenerative disorders. Recent...

journal_title：PLoS biology

authors： Dröse S,Krack S,Sokolova L,Zwicker K,Barth HD,Morgner N,Heide H,Steger M,Nübel E,Zickermann V,Kerscher S,Brutschy B,Radermacher M,Brandt U

更新日期：2011-08-01 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GPCRs) in this dynamic germline regulation. By genome-enabled receptor ...

journal_title：PLoS biology

authors： Saberi A,Jamal A,Beets I,Schoofs L,Newmark PA

更新日期：2016-05-10 00:00:00

abstract：:A large repertoire of natural object manipulation tasks require precisely coupled symmetrical opposing forces by both hands on a single object. We asked how the lateralized brain handles this basic problem of spatial and temporal coordination. We show that the brain consistently appoints one of the hands as prime acto...

journal_title：PLoS biology

authors： Johansson RS,Theorin A,Westling G,Andersson M,Ohki Y,Nyberg L

更新日期：2006-06-01 00:00:00

abstract：:In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate the molecular mechan...

journal_title：PLoS biology

authors： Montaville P,Jégou A,Pernier J,Compper C,Guichard B,Mogessie B,Schuh M,Romet-Lemonne G,Carlier MF

更新日期：2014-02-25 00:00:00

abstract：:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits. ...

journal_title：PLoS biology

authors： Richardson LA

更新日期：2018-10-04 00:00:00

abstract：:To successfully negotiate a complex environment, an animal must control the timing of motor behaviors in coordination with dynamic sensory information. Here, we report on adaptive temporal control of vocal-motor behavior in an echolocating bat, Eptesicus fuscus, as it captured tethered insects close to background vege...

journal_title：PLoS biology

authors： Moss CF,Bohn K,Gilkenson H,Surlykke A

更新日期：2006-04-01 00:00:00

abstract：:Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/TFE family of transc...

journal_title：PLoS biology

authors： Murphy JT,Liu H,Ma X,Shaver A,Egan BM,Oh C,Boyko A,Mazer T,Ang S,Khopkar R,Javaheri A,Kumar S,Jiang X,Ory D,Mani K,Matkovich SJ,Kornfeld K,Diwan A

更新日期：2019-05-14 00:00:00

abstract：:Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...

journal_title：PLoS biology

authors： Knapp BD,Zhu L,Huang KC

更新日期：2020-11-06 00:00:00

abstract：:Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a critical regulator o...

journal_title：PLoS biology

authors： Zhang X,Chen W,Gao Q,Yang J,Yan X,Zhao H,Su L,Yang M,Gao C,Yao Y,Inoki K,Li D,Shao R,Wang S,Sahoo N,Kudo F,Eguchi T,Ruan B,Xu H

更新日期：2019-05-21 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analyzing primary chicke...

journal_title：PLoS biology

authors： Richard A,Boullu L,Herbach U,Bonnafoux A,Morin V,Vallin E,Guillemin A,Papili Gao N,Gunawan R,Cosette J,Arnaud O,Kupiec JJ,Espinasse T,Gonin-Giraud S,Gandrillon O

更新日期：2016-12-27 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:DEAD-box proteins are ubiquitous regulators of RNA biology. While commonly dubbed "helicases," their activities also include duplex annealing, adenosine triphosphate (ATP)-dependent RNA binding, and RNA-protein complex remodeling. Rok1, an essential DEAD-box protein, and its cofactor Rrp5 are required for ribosome ass...

journal_title：PLoS biology

authors： Khoshnevis S,Askenasy I,Johnson MC,Dattolo MD,Young-Erdos CL,Stroupe ME,Karbstein K

更新日期：2016-06-09 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002436.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2016-06-08 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:In adults, the growth of blood vessels, a process known as angiogenesis, is essential for organ growth and repair. In many disorders including cancer, angiogenesis becomes excessive. The cellular origin of new vascular endothelial cells (ECs) during blood vessel growth in angiogenic situations has remained unknown. He...

journal_title：PLoS biology

authors： Fang S,Wei J,Pentinmikko N,Leinonen H,Salven P

更新日期：2012-01-01 00:00:00

abstract：:From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae cells treated with...

journal_title：PLoS biology

authors： Gasch AP,Yu FB,Hose J,Escalante LE,Place M,Bacher R,Kanbar J,Ciobanu D,Sandor L,Grigoriev IV,Kendziorski C,Quake SR,McClean MN

更新日期：2017-12-14 00:00:00