Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative.

Abstract:

:The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a unique opportunity to examine the role of institutions. The Berlin Institute of Health founded QUEST to increase the likelihood that research conducted at this large academic medical center would be trustworthy, useful for scientists and society, and ethical. QUEST researchers perform "science of science" studies to understand problems with standard practices and develop targeted solutions. The staff work with institutional leadership and local scientists to incentivize and support responsible practices in research, funding, and hiring. Some activities described in this paper focus on the institution, whereas others may benefit the national and international scientific community. Our experience, approaches, and recommendations will be informative for faculty leadership, administrators, and researchers interested in improving scientific practice.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Strech D,Weissgerber T,Dirnagl U,QUEST Group.

doi

10.1371/journal.pbio.3000576

subject

Has Abstract

pub_date

2020-02-11 00:00:00

pages

e3000576

issue

2

eissn

1544-9173

issn

1545-7885

pii

PBIOLOGY-D-19-03177

journal_volume

18

pub_type

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