Abstract:
:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome biogenesis is also controlled directly at the posttranscriptional level. We show that Tor1 and casein kinase 2 (CK2) kinases regulate a rapid switch between a productive and a non-productive pre-rRNA processing pathways in yeast. Under stress, the pre-rRNA continues to be synthesized; however, it is processed differently, and no new ribosomes are produced. Strikingly, the control of the switch does not require the Sch9 kinase, indicating that an unrecognized Tor Complex 1 (TORC1) signaling branch involving CK2 kinase directly regulates ribosome biogenesis at the posttranscriptional level.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Kos-Braun IC,Jung I,Koš Mdoi
10.1371/journal.pbio.2000245subject
Has Abstractpub_date
2017-03-10 00:00:00pages
e2000245issue
3eissn
1544-9173issn
1545-7885pii
pbio.2000245journal_volume
15pub_type
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