The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot.

abstract：:Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a framework for underst...

journal_title：PLoS biology

authors： Gao Z,Wyman MJ,Sella G,Przeworski M

更新日期：2016-01-13 00:00:00

abstract：:Rapidly grouping local elements into an organized object (i.e., perceptual integration) is a fundamental yet challenging task, especially in noisy contexts. Previous studies demonstrate that ventral visual pathway, which is widely known to mediate object recognition, engages in the process by conveying object-level in...

journal_title：PLoS biology

authors： Liu L,Wang F,Zhou K,Ding N,Luo H

更新日期：2017-11-30 00:00:00

abstract：:FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important functions in devel...

journal_title：PLoS biology

authors： Sancho R,Blake SM,Tendeng C,Clurman BE,Lewis J,Behrens A

更新日期：2013-01-01 00:00:00

abstract：:Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...

journal_title：PLoS biology

authors： Chao DY,Chen Y,Chen J,Shi S,Chen Z,Wang C,Danku JM,Zhao FJ,Salt DE

更新日期：2014-12-02 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have designed synthetic "s...

journal_title：PLoS biology

authors： Francica JR,Laga R,Lynn GM,Mužíková G,Androvič L,Aussedat B,Walkowicz WE,Padhan K,Ramirez-Valdez RA,Parks R,Schmidt SD,Flynn BJ,Tsybovsky Y,Stewart-Jones GBE,Saunders KO,Baharom F,Petrovas C,Haynes BF,Seder RA

更新日期：2019-06-17 00:00:00

abstract：:Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine...

journal_title：PLoS biology

authors： Geissmann Q,Garcia Rodriguez L,Beckwith EJ,French AS,Jamasb AR,Gilestro GF

更新日期：2017-10-19 00:00:00

abstract：:The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men....

journal_title：PLoS biology

authors： Balaresque P,Bowden GR,Adams SM,Leung HY,King TE,Rosser ZH,Goodwin J,Moisan JP,Richard C,Millward A,Demaine AG,Barbujani G,Previderè C,Wilson IJ,Tyler-Smith C,Jobling MA

更新日期：2010-01-19 00:00:00

abstract：:Why do we sleep? The sleep patterns and mechanisms that occur throughout development may give us a clue. ...

journal_title：PLoS biology

authors： Siegel JM

更新日期：2005-05-01 00:00:00

abstract：:Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment i...

journal_title：PLoS biology

authors： Hirst J,Barlow LD,Francisco GC,Sahlender DA,Seaman MN,Dacks JB,Robinson MS

更新日期：2011-10-01 00:00:00

abstract：:Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...

journal_title：PLoS biology

authors： Fatsis-Kavalopoulos N,Roemhild R,Tang PC,Kreuger J,Andersson DI

更新日期：2020-09-17 00:00:00

abstract：:The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...

journal_title：PLoS biology

authors： Yang C,Naya Y

更新日期：2020-11-18 00:00:00

abstract：:Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a method that exploits ...

journal_title：PLoS biology

authors： Kallimasioti-Pazi EM,Thelakkad Chathoth K,Taylor GC,Meynert A,Ballinger T,Kelder MJE,Lalevée S,Sanli I,Feil R,Wood AJ

更新日期：2018-12-12 00:00:00

abstract：:In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the los...

journal_title：PLoS biology

authors： Newell PD,Boyd CD,Sondermann H,O'Toole GA

更新日期：2011-02-01 00:00:00

abstract：:Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to determine whether gene flow would be facilitated or hampered following ...

journal_title：PLoS biology

authors： Ono J,Gerstein AC,Otto SP

更新日期：2017-01-23 00:00:00

abstract：:Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...

journal_title：PLoS biology

authors： Pejchal R,Ludwig ML

更新日期：2005-02-01 00:00:00

abstract：:Malaria transmission is known to be strongly impacted by temperature. The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies. These studies, some dating back to the early part of last century, are often poorly controlled, have l...

journal_title：PLoS biology

authors： Shapiro LLM,Whitehead SA,Thomas MB

更新日期：2017-10-16 00:00:00

abstract：:The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcript...

journal_title：PLoS biology

authors： Meeske AJ,Rodrigues CD,Brady J,Lim HC,Bernhardt TG,Rudner DZ

更新日期：2016-01-06 00:00:00

abstract：:There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo. Here, by using the multi-protein tip complex of the mannose-binding type 1 fimb...

journal_title：PLoS biology

authors： Aprikian P,Interlandi G,Kidd BA,Le Trong I,Tchesnokova V,Yakovenko O,Whitfield MJ,Bullitt E,Stenkamp RE,Thomas WE,Sokurenko EV

更新日期：2011-05-01 00:00:00

abstract：:The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...

journal_title：PLoS biology

authors： de Sousa N,Rodríguez-Esteban G,Rojo-Laguna JI,Saló E,Adell T

更新日期：2018-01-22 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the nasc...

journal_title：PLoS biology

authors： Lintner NG,McClure KF,Petersen D,Londregan AT,Piotrowski DW,Wei L,Xiao J,Bolt M,Loria PM,Maguire B,Geoghegan KF,Huang A,Rolph T,Liras S,Doudna JA,Dullea RG,Cate JH

更新日期：2017-03-21 00:00:00

abstract：:The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies. Cajal bodies are nuclear organelles involved in diverse functions such as processing ribonucleoproteins important for splicing. Here we identify the...

journal_title：PLoS biology

authors： Mahmoudi S,Henriksson S,Weibrecht I,Smith S,Söderberg O,Strömblad S,Wiman KG,Farnebo M

更新日期：2010-11-02 00:00:00

abstract：:The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo sup...

journal_title：PLoS biology

authors： Braitsch CM,Azizoglu DB,Htike Y,Barlow HR,Schnell U,Chaney CP,Carroll TJ,Stanger BZ,Cleaver O

更新日期：2019-07-19 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip has been reported in many vertebrates. However, the knowledge about the subcellular dynamics and molecular mechanisms regulating directional neuronal migration in vivo is just beginning to emerge. Here we show by time-lapse ...

journal_title：PLoS biology

authors： Rieger S,Senghaas N,Walch A,Köster RW

更新日期：2009-11-01 00:00:00

abstract：:Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this function...

journal_title：PLoS biology

authors： Kushnareva Y,Andreyev AY,Kuwana T,Newmeyer DD

更新日期：2012-01-01 00:00:00

abstract：:Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...

journal_title：PLoS biology

authors： Meharena HS,Fan X,Ahuja LG,Keshwani MM,McClendon CL,Chen AM,Adams JA,Taylor SS

更新日期：2016-11-30 00:00:00

abstract：:Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by...

journal_title：PLoS biology

authors： Thut G

更新日期：2014-12-30 00:00:00

abstract：:Sensory loss induces cross-modal plasticity, often resulting in altered performance in remaining sensory modalities. Whereas much is known about the macroscopic mechanisms underlying cross-modal plasticity, only scant information exists about its cellular and molecular underpinnings. We found that Caenorhabditis elega...

journal_title：PLoS biology

authors： Rabinowitch I,Laurent P,Zhao B,Walker D,Beets I,Schoofs L,Bai J,Schafer WR,Treinin M

更新日期：2016-01-08 00:00:00