Hippo signaling controls cell cycle and restricts cell plasticity in planarians.

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...

journal_title：PLoS biology

authors： Kompella P,Gracia B,LeBlanc L,Engelman S,Kulkarni C,Desai N,June V,March S,Pattengale S,Rodriguez-Rivera G,Ryu SW,Strohkendl I,Mandke P,Clark G

更新日期：2020-03-30 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp. p45/NRH2/PLAIDD is a p75 homologue and contains a death domain (DD). Here we report th...

journal_title：PLoS biology

authors： Vilar M,Sung TC,Chen Z,García-Carpio I,Fernandez EM,Xu J,Riek R,Lee KF

更新日期：2014-08-05 00:00:00

abstract：:The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a phase of massive growth and concomitant patterning during larval s...

journal_title：PLoS biology

authors： Hamaratoglu F,de Lachapelle AM,Pyrowolakis G,Bergmann S,Affolter M

更新日期：2011-10-01 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...

journal_title：PLoS biology

authors： Chao DY,Chen Y,Chen J,Shi S,Chen Z,Wang C,Danku JM,Zhao FJ,Salt DE

更新日期：2014-12-02 00:00:00

abstract：:HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the functional conformation of the HAP2 fusion loo...

journal_title：PLoS biology

authors： Fedry J,Forcina J,Legrand P,Péhau-Arnaudet G,Haouz A,Johnson M,Rey FA,Krey T

更新日期：2018-08-13 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

journal_title：PLoS biology

authors： Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

更新日期：2021-01-04 00:00:00

abstract：:We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

journal_title：PLoS biology

authors： Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

更新日期：2006-03-01 00:00:00

abstract：:The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo sup...

journal_title：PLoS biology

authors： Braitsch CM,Azizoglu DB,Htike Y,Barlow HR,Schnell U,Chaney CP,Carroll TJ,Stanger BZ,Cleaver O

更新日期：2019-07-19 00:00:00

abstract：:In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targ...

journal_title：PLoS biology

authors： Lewis TL Jr,Mao T,Arnold DB

更新日期：2011-03-01 00:00:00

abstract：:Rapid colour change is a remarkable natural phenomenon that has evolved in several vertebrate and invertebrate lineages. The two principal explanations for the evolution of this adaptive strategy are (1) natural selection for crypsis (camouflage) against a range of different backgrounds and (2) selection for conspicuo...

journal_title：PLoS biology

authors： Stuart-Fox D,Moussalli A

更新日期：2008-01-01 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...

journal_title：PLoS biology

authors： San Pietro E,Capestrano M,Polishchuk EV,DiPentima A,Trucco A,Zizza P,Mariggiò S,Pulvirenti T,Sallese M,Tete S,Mironov AA,Leslie CC,Corda D,Luini A,Polishchuk RS

更新日期：2009-09-01 00:00:00

abstract：:The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regions of the longest ...

journal_title：PLoS biology

authors： Sherwood NT,Sun Q,Xue M,Zhang B,Zinn K

更新日期：2004-12-01 00:00:00

abstract：:From early dinosaurs with as many as nine wrist bones, modern birds evolved to develop only four ossifications. Their identity is uncertain, with different labels used in palaeontology and developmental biology. We examined embryos of several species and studied chicken embryos in detail through a new technique allowi...

journal_title：PLoS biology

authors： Botelho JF,Ossa-Fuentes L,Soto-Acuña S,Smith-Paredes D,Nuñez-León D,Salinas-Saavedra M,Ruiz-Flores M,Vargas AO

更新日期：2014-09-30 00:00:00

abstract：:Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

journal_title：PLoS biology

authors： Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

更新日期：2006-05-01 00:00:00

abstract：:FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...

journal_title：PLoS biology

authors： Strauss MP,Liew AT,Turnbull L,Whitchurch CB,Monahan LG,Harry EJ

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantage. The resulting frequency-dependent selection can structure parasite populations into strains of limited genetic overlap. For the causative agent of malaria, Plasmodium falciparum, the hig...

journal_title：PLoS biology

authors： Pilosof S,He Q,Tiedje KE,Ruybal-Pesántez S,Day KP,Pascual M

更新日期：2019-06-24 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

journal_title：PLoS biology

authors： Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

更新日期：2013-01-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

journal_title：PLoS biology

authors： Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

更新日期：2018-09-27 00:00:00

abstract：:Previously it was shown that male mice, when they encounter female mice or their pheromones, emit ultrasonic vocalizations with frequencies ranging over 30-110 kHz. Here, we show that these vocalizations have the characteristics of song, consisting of several different syllable types, whose temporal sequencing include...

journal_title：PLoS biology

authors： Holy TE,Guo Z

更新日期：2005-12-01 00:00:00

abstract：:Motion is an essential component of everyday tactile experience: most manual interactions involve relative movement between the skin and objects. Much of the research on the neural basis of tactile motion perception has focused on how direction is encoded, but less is known about how speed is. Perceived speed has been...

journal_title：PLoS biology

authors： Delhaye BP,O'Donnell MK,Lieber JD,McLellan KR,Bensmaia SJ

更新日期：2019-08-27 00:00:00