Location coding by opponent neural populations in the auditory cortex.

Abstract:

:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located far to the left or right side, with few neurons tuned to the frontal midline. Paradoxically, psychophysical studies show optimal spatial acuity across the frontal midline. In this paper, we revisit the problem of inhomogeneous spatial sampling in three fields of cat auditory cortex. In each field, we confirm that neural responses tend to be greatest for lateral positions, but show the greatest modulation for near-midline source locations. Moreover, identification of source locations based on cortical responses shows sharp discrimination of left from right but relatively inaccurate discrimination of locations within each half of space. Motivated by these findings, we explore an opponent-process theory in which sound-source locations are represented by differences in the activity of two broadly tuned channels formed by contra- and ipsilaterally preferring neurons. Finally, we demonstrate a simple model, based on spike-count differences across cortical populations, that provides bias-free, level-invariant localization-and thus also a solution to the "binding problem" of associating spatial information with other nonspatial attributes of sounds.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Stecker GC,Harrington IA,Middlebrooks JC

doi

10.1371/journal.pbio.0030078

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

e78

issue

3

eissn

1544-9173

issn

1545-7885

pii

04-PLBI-RA-0862R1

journal_volume

3

pub_type

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