Abstract:
:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. Mitotic receptor storage, as delineated in this study, may facilitate rapid reestablishment of signaling competence in nascent daughter cells. However, mutations that limit or enhance the release of stored signaling components could alter daughter cell fate or behavior thereby promoting oncogenesis.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson Bdoi
10.1371/journal.pbio.3001029subject
Has Abstractpub_date
2021-01-04 00:00:00pages
e3001029issue
1eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-20-00218journal_volume
19pub_type
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