Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor.

Abstract:

:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. Mitotic receptor storage, as delineated in this study, may facilitate rapid reestablishment of signaling competence in nascent daughter cells. However, mutations that limit or enhance the release of stored signaling components could alter daughter cell fate or behavior thereby promoting oncogenesis.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

doi

10.1371/journal.pbio.3001029

subject

Has Abstract

pub_date

2021-01-04 00:00:00

pages

e3001029

issue

1

eissn

1544-9173

issn

1545-7885

pii

PBIOLOGY-D-20-00218

journal_volume

19

pub_type

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