Functional implications of sleep development.

abstract：:Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to determine whether gene flow would be facilitated or hampered following ...

journal_title：PLoS biology

authors： Ono J,Gerstein AC,Otto SP

更新日期：2017-01-23 00:00:00

abstract：:Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. He...

journal_title：PLoS biology

authors： Ni X,Zhang YE,Nègre N,Chen S,Long M,White KP

更新日期：2012-01-01 00:00:00

abstract：:Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties, but the mechanisms regulating synapse-specific Ca2+ homeostasis in...

journal_title：PLoS biology

authors： Kwon SK,Sando R 3rd,Lewis TL,Hirabayashi Y,Maximov A,Polleux F

更新日期：2016-07-18 00:00:00

abstract：:The segmentation gene network of Drosophila consists of maternal and zygotic factors that generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity along the anterior-posterior axis of the embryo. Using known binding site information for maternal and zygotic gap transcription facto...

journal_title：PLoS biology

authors： Schroeder MD,Pearce M,Fak J,Fan H,Unnerstall U,Emberly E,Rajewsky N,Siggia ED,Gaul U

更新日期：2004-09-01 00:00:00

abstract：:In Amazonian tropical forests, recent studies have reported increases in aboveground biomass and in primary productivity, as well as shifts in plant species composition favouring fast-growing species over slow-growing ones. This pervasive alteration of mature tropical forests was attributed to global environmental cha...

journal_title：PLoS biology

authors： Chave J,Condit R,Muller-Landau HC,Thomas SC,Ashton PS,Bunyavejchewin S,Co LL,Dattaraja HS,Davies SJ,Esufali S,Ewango CE,Feeley KJ,Foster RB,Gunatilleke N,Gunatilleke S,Hall P,Hart TB,Hernández C,Hubbell SP,Itoh A,

更新日期：2008-03-04 00:00:00

abstract：:Over the past 3 decades, in a series of studies on some of the most extensively studied toxic chemicals and pollutants, scientists have found that the amount of toxic chemical linked with the development of a disease or death-which is central to determining "safe" or "hazardous" levels-is proportionately greater at th...

journal_title：PLoS biology

authors： Lanphear BP

更新日期：2017-12-19 00:00:00

abstract：:Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...

journal_title：PLoS biology

authors： Krylova O,Earn DJD

更新日期：2020-12-21 00:00:00

abstract：:Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments. In metazoans, monomeric actin polymerises into usually long and stable filaments, while some protozoans form only short and highly dynamic actin filaments. These different dynamics are partl...

journal_title：PLoS biology

authors： Douglas RG,Nandekar P,Aktories JE,Kumar H,Weber R,Sattler JM,Singer M,Lepper S,Sadiq SK,Wade RC,Frischknecht F

更新日期：2018-07-16 00:00:00

abstract：:There is currently a demand for new highly efficient and specific drugs to treat osteoporosis, a chronic bone disease affecting millions of people worldwide. We have developed a combinatorial strategy for engineering bispecific inhibitors that simultaneously target the unique combination of c-FMS and αvβ3 integrin, wh...

journal_title：PLoS biology

authors： Zur Y,Rosenfeld L,Keshelman CA,Dalal N,Guterman-Ram G,Orenbuch A,Einav Y,Levaot N,Papo N

更新日期：2018-08-24 00:00:00

abstract：:The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...

journal_title：PLoS biology

authors： Abascal F,Posada D,Knight RD,Zardoya R

更新日期：2006-05-01 00:00:00

abstract：:Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity of opposing kinase signaling complexes has remained elusive. We report...

journal_title：PLoS biology

authors： Merrill RA,Dagda RK,Dickey AS,Cribbs JT,Green SH,Usachev YM,Strack S

更新日期：2011-04-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than other cells and might t...

journal_title：PLoS biology

authors： Silva J,Barrandon O,Nichols J,Kawaguchi J,Theunissen TW,Smith A

更新日期：2008-10-21 00:00:00

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phen...

journal_title：PLoS biology

authors： Leone TC,Lehman JJ,Finck BN,Schaeffer PJ,Wende AR,Boudina S,Courtois M,Wozniak DF,Sambandam N,Bernal-Mizrachi C,Chen Z,Holloszy JO,Medeiros DM,Schmidt RE,Saffitz JE,Abel ED,Semenkovich CF,Kelly DP

更新日期：2005-04-01 00:00:00

abstract：:Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those...

journal_title：PLoS biology

authors： Merrow M,Harrington M

更新日期：2020-10-14 00:00:00

abstract：:Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

journal_title：PLoS biology

authors： Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

更新日期：2006-05-01 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies. Cajal bodies are nuclear organelles involved in diverse functions such as processing ribonucleoproteins important for splicing. Here we identify the...

journal_title：PLoS biology

authors： Mahmoudi S,Henriksson S,Weibrecht I,Smith S,Söderberg O,Strömblad S,Wiman KG,Farnebo M

更新日期：2010-11-02 00:00:00

abstract：:Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide (HX). This paradigm is at the basis of the vast majority of expe...

journal_title：PLoS biology

authors： Hudry B,Remacle S,Delfini MC,Rezsohazy R,Graba Y,Merabet S

更新日期：2012-01-01 00:00:00

abstract：:Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the activation of self-reactive B cells; however, the mechanism underlying the negative regulation of ...

journal_title：PLoS biology

authors： Liu C,Bai X,Wu J,Sharma S,Upadhyaya A,Dahlberg CI,Westerberg LS,Snapper SB,Zhao X,Song W

更新日期：2013-11-01 00:00:00

abstract：:The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic variation. During sexual genome development, the expressed, somatic macronuclear genome is whittled down to the genic portion of a small fraction (∼5%) of its precursor "silen...

journal_title：PLoS biology

authors： Swart EC,Bracht JR,Magrini V,Minx P,Chen X,Zhou Y,Khurana JS,Goldman AD,Nowacki M,Schotanus K,Jung S,Fulton RS,Ly A,McGrath S,Haub K,Wiggins JL,Storton D,Matese JC,Parsons L,Chang WJ,Bowen MS,Stover NA,Jones T

更新日期：2013-01-01 00:00:00

abstract：:Using DNA sequences 5' to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans. This effort encompasses about 10% of all genes identified in this organism. GFP-expre...

journal_title：PLoS biology

authors： Hunt-Newbury R,Viveiros R,Johnsen R,Mah A,Anastas D,Fang L,Halfnight E,Lee D,Lin J,Lorch A,McKay S,Okada HM,Pan J,Schulz AK,Tu D,Wong K,Zhao Z,Alexeyenko A,Burglin T,Sonnhammer E,Schnabel R,Jones SJ,Marra MA,

更新日期：2007-09-01 00:00:00

abstract：:A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly ...

journal_title：PLoS biology

authors： Shirangi TR,Dufour HD,Williams TM,Carroll SB

更新日期：2009-08-01 00:00:00

abstract：:Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...

journal_title：PLoS biology

authors： Maia Chagas A

更新日期：2018-09-27 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejecte...

journal_title：PLoS biology

authors： McGaugh SE,Heil CS,Manzano-Winkler B,Loewe L,Goldstein S,Himmel TL,Noor MA

更新日期：2012-01-01 00:00:00

abstract：:Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...

journal_title：PLoS biology

authors： Sharp NP,Agrawal AF

更新日期：2016-03-25 00:00:00

abstract：:The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...

journal_title：PLoS biology

authors： Bossuyt W,De Geest N,Aerts S,Leenaerts I,Marynen P,Hassan BA

更新日期：2009-02-24 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...

journal_title：PLoS biology

authors： Lu W,Hu Y,Chen G,Chen Z,Zhang H,Wang F,Feng L,Pelicano H,Wang H,Keating MJ,Liu J,McKeehan W,Wang H,Luo Y,Huang P

更新日期：2017-12-11 00:00:00

abstract：:Several strategies have been pursued to increase the extent of exon 7 inclusion during splicing of SMN2 (survival of motor neuron 2) transcripts, for eventual therapeutic use in spinal muscular atrophy (SMA), a genetic neuromuscular disease. Antisense oligonucleotides (ASOs) that target an exon or its flanking splice ...

journal_title：PLoS biology

authors： Hua Y,Vickers TA,Baker BF,Bennett CF,Krainer AR

更新日期：2007-04-01 00:00:00