Abstract:
:Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote access to scientific equipment necessary for experiments. Mostly due to monetary constraints, equipment availability has always been uneven around the globe, affecting predominantly low-income countries and institutions. Here, a case is made for the use of free open source hardware in research and education, including countries and institutions where funds were never the biggest problem.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Maia Chagas Adoi
10.1371/journal.pbio.3000014subject
Has Abstractpub_date
2018-09-27 00:00:00pages
e3000014issue
9eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-18-00242journal_volume
16pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Motion is an essential component of everyday tactile experience: most manual interactions involve relative movement between the skin and objects. Much of the research on the neural basis of tactile motion perception has focused on how direction is encoded, but less is known about how speed is. Perceived speed has been...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000431
更新日期:2019-08-27 00:00:00
abstract::A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002118
更新日期:2015-04-09 00:00:00
abstract::The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints du...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000537
更新日期:2010-11-09 00:00:00
abstract::In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000019
更新日期:2018-09-24 00:00:00
abstract::Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003355
更新日期:2017-11-28 00:00:00
abstract::Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002243
更新日期:2015-09-10 00:00:00
abstract::G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000434
更新日期:2019-11-25 00:00:00
abstract::In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2000111
更新日期:2016-08-15 00:00:00
abstract::The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex pl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001220
更新日期:2017-05-03 00:00:00
abstract::To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000110
更新日期:2009-05-05 00:00:00
abstract::Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-embryos display an identical phenotype, indicating that these ce...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000287
更新日期:2019-05-29 00:00:00
abstract::The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000090
更新日期:2009-04-21 00:00:00
abstract::Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030225
更新日期:2005-07-01 00:00:00
abstract::Almost all higher organisms, including plants, insects, and mammals, are colonized by complex microbial communities and harbor a microbiome. Emerging studies with plants reveal that these microbiomes are structured and form complex, interconnected microbial networks. Within these networks, different taxa have differen...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1002378
更新日期:2016-02-12 00:00:00
abstract::When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...
journal_title:PLoS biology
pub_type: 临床试验,杂志文章
doi:10.1371/journal.pbio.0040028
更新日期:2006-02-01 00:00:00
abstract::Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002089
更新日期:2015-03-12 00:00:00
abstract::In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050322
更新日期:2007-12-01 00:00:00
abstract::The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040127
更新日期:2006-05-01 00:00:00
abstract::Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. The obesity epidemic shows no sign of slowing, and it is increasingly a global problem. Serious clinical problems associated with obesity includ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001436
更新日期:2012-01-01 00:00:00
abstract::While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000284
更新日期:2019-05-20 00:00:00
abstract::Putting a name to a face is a highly common activity in our daily life that greatly enriches social interactions. Although this specific person-identity association becomes automatic with learning, it remains difficult and can easily be disrupted in normal circumstances or neurological conditions. To shed light on the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000659
更新日期:2020-04-03 00:00:00
abstract::Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000125
更新日期:2019-01-29 00:00:00
abstract::Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050012
更新日期:2007-01-01 00:00:00
abstract::The Amazon is Brazil's greatest natural resource and invaluable to the rest of the world as a buffer against climate change. The recent election of Brazil's president brought disputes over development plans for the region back into the spotlight. Historically, the development model for the Amazon has focused on exploi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000526
更新日期:2019-11-15 00:00:00
abstract::Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000898
更新日期:2020-10-20 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2002794.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002615
更新日期:2017-11-01 00:00:00
abstract::Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000087
更新日期:2019-09-03 00:00:00
abstract::In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate m...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000182
更新日期:2019-03-29 00:00:00
abstract::CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005970
更新日期:2018-07-03 00:00:00
abstract::It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003782
更新日期:2018-03-29 00:00:00