Haves and have nots must find a better way: The case for open scientific hardware.

abstract：:Motion is an essential component of everyday tactile experience: most manual interactions involve relative movement between the skin and objects. Much of the research on the neural basis of tactile motion perception has focused on how direction is encoded, but less is known about how speed is. Perceived speed has been...

journal_title：PLoS biology

authors： Delhaye BP,O'Donnell MK,Lieber JD,McLellan KR,Bensmaia SJ

更新日期：2019-08-27 00:00:00

abstract：:A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...

journal_title：PLoS biology

authors： Reindl KM,White AR,Johnson C,Vender B,Slator BM,McClean P

更新日期：2015-04-09 00:00:00

abstract：:The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints du...

journal_title：PLoS biology

authors： Green AA,Kennaway JR,Hanna AI,Bangham JA,Coen E

更新日期：2010-11-09 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...

journal_title：PLoS biology

authors： Hock K,Wolff NH,Ortiz JC,Condie SA,Anthony KRN,Blackwell PG,Mumby PJ

更新日期：2017-11-28 00:00:00

abstract：:Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...

journal_title：PLoS biology

authors： Wang S,Jiang B,Zhang T,Liu L,Wang Y,Wang Y,Chen X,Lin H,Zhou L,Xia Y,Chen L,Yang C,Xiong Y,Ye D,Guan KL

更新日期：2015-09-10 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...

journal_title：PLoS biology

authors： Sriram K,Moyung K,Corriden R,Carter H,Insel PA

更新日期：2019-11-25 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex pl...

journal_title：PLoS biology

authors： Moon BS,Yun HM,Chang WH,Steele BH,Cai M,Choi SH,Lu W

更新日期：2017-05-03 00:00:00

abstract：:To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...

journal_title：PLoS biology

authors： Wolfe BA,Takaki T,Petronczki M,Glotzer M

更新日期：2009-05-05 00:00:00

abstract：:Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-embryos display an identical phenotype, indicating that these ce...

journal_title：PLoS biology

authors： Lee KM,Wilson GJ,Pingen M,Fukuoka A,Hansell CAH,Bartolini R,Medina-Ruiz L,Graham GJ

更新日期：2019-05-29 00:00:00

abstract：:The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...

journal_title：PLoS biology

authors： Kaufmann K,Muiño JM,Jauregui R,Airoldi CA,Smaczniak C,Krajewski P,Angenent GC

更新日期：2009-04-21 00:00:00

abstract：:Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

journal_title：PLoS biology

authors： Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

更新日期：2005-07-01 00:00:00

abstract：:Almost all higher organisms, including plants, insects, and mammals, are colonized by complex microbial communities and harbor a microbiome. Emerging studies with plants reveal that these microbiomes are structured and form complex, interconnected microbial networks. Within these networks, different taxa have differen...

journal_title：PLoS biology

authors： van der Heijden MG,Hartmann M

更新日期：2016-02-12 00:00:00

abstract：:When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...

journal_title：PLoS biology

authors： Bays PM,Flanagan JR,Wolpert DM

更新日期：2006-02-01 00:00:00

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00

abstract：:In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...

journal_title：PLoS biology

authors： Palazzo AF,Springer M,Shibata Y,Lee CS,Dias AP,Rapoport TA

更新日期：2007-12-01 00:00:00

abstract：:The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...

journal_title：PLoS biology

authors： Abascal F,Posada D,Knight RD,Zardoya R

更新日期：2006-05-01 00:00:00

abstract：:Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. The obesity epidemic shows no sign of slowing, and it is increasingly a global problem. Serious clinical problems associated with obesity includ...

journal_title：PLoS biology

authors： Stephens JM

更新日期：2012-01-01 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:Putting a name to a face is a highly common activity in our daily life that greatly enriches social interactions. Although this specific person-identity association becomes automatic with learning, it remains difficult and can easily be disrupted in normal circumstances or neurological conditions. To shed light on the...

journal_title：PLoS biology

authors： Volfart A,Jonas J,Maillard L,Colnat-Coulbois S,Rossion B

更新日期：2020-04-03 00:00:00

abstract：:Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...

journal_title：PLoS biology

authors： Yenni GM,Christensen EM,Bledsoe EK,Supp SR,Diaz RM,White EP,Ernest SKM

更新日期：2019-01-29 00:00:00

abstract：:Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...

journal_title：PLoS biology

authors： Grent-'t-Jong T,Woldorff MG

更新日期：2007-01-01 00:00:00

abstract：:The Amazon is Brazil's greatest natural resource and invaluable to the rest of the world as a buffer against climate change. The recent election of Brazil's president brought disputes over development plans for the region back into the spotlight. Historically, the development model for the Amazon has focused on exploi...

journal_title：PLoS biology

authors： Castro MC,Baeza A,Codeço CT,Cucunubá ZM,Dal'Asta AP,De Leo GA,Dobson AP,Carrasco-Escobar G,Lana RM,Lowe R,Monteiro AMV,Pascual M,Santos-Vega M

更新日期：2019-11-15 00:00:00

abstract：:Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...

journal_title：PLoS biology

authors： Tomassini A,Maris E,Hilt P,Fadiga L,D'Ausilio A

更新日期：2020-10-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2002794.]. ...

journal_title：PLoS biology

authors： Obleser J,Henry MJ,Lakatos P

更新日期：2017-11-01 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate m...

journal_title：PLoS biology

authors： Kaminski Strauss S,Schirman D,Jona G,Brooks AN,Kunjapur AM,Nguyen Ba AN,Flint A,Solt A,Mershin A,Dixit A,Yona AH,Csörgő B,Busby BP,Hennig BP,Pál C,Schraivogel D,Schultz D,Wernick DG,Agashe D,Levi D,Zabezhinsky D,

更新日期：2019-03-29 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffec...

journal_title：PLoS biology

authors： Yao CH,Liu GY,Wang R,Moon SH,Gross RW,Patti GJ

更新日期：2018-03-29 00:00:00