A functional context for heterogeneity of the circadian clock in cells.

abstract：:Recent findings suggest that functional brain imaging might be used to identify consciousness in patients diagnosed with persistent vegetative state and minimally conscious state. Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats. ...

journal_title：PLoS biology

authors： Rafii MS,Brewer JB

更新日期：2010-11-30 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:Over the last decades, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and behavior. This arduous work has yielded results with far-reaching consequences in metabolic, psychiatric, and neoplastic disorders. Recent attempts to expand our understanding of circadian regulation...

journal_title：PLoS biology

authors： Anafi RC,Lee Y,Sato TK,Venkataraman A,Ramanathan C,Kavakli IH,Hughes ME,Baggs JE,Growe J,Liu AC,Kim J,Hogenesch JB

更新日期：2014-04-15 00:00:00

abstract：:The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men....

journal_title：PLoS biology

authors： Balaresque P,Bowden GR,Adams SM,Leung HY,King TE,Rosser ZH,Goodwin J,Moisan JP,Richard C,Millward A,Demaine AG,Barbujani G,Previderè C,Wilson IJ,Tyler-Smith C,Jobling MA

更新日期：2010-01-19 00:00:00

abstract：:Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

journal_title：PLoS biology

authors： Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

更新日期：2005-07-01 00:00:00

abstract：:Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/TFE family of transc...

journal_title：PLoS biology

authors： Murphy JT,Liu H,Ma X,Shaver A,Egan BM,Oh C,Boyko A,Mazer T,Ang S,Khopkar R,Javaheri A,Kumar S,Jiang X,Ory D,Mani K,Matkovich SJ,Kornfeld K,Diwan A

更新日期：2019-05-14 00:00:00

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00

abstract：:Unc-51-like autophagy activating kinase 1 (ULK1)-autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions. However, their phospho-regul...

journal_title：PLoS biology

authors： Li Z,Tian X,Ji X,Wang J,Chen H,Wang D,Zhang X

更新日期：2020-06-09 00:00:00

abstract：:Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment i...

journal_title：PLoS biology

authors： Hirst J,Barlow LD,Francisco GC,Sahlender DA,Seaman MN,Dacks JB,Robinson MS

更新日期：2011-10-01 00:00:00

abstract：:The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...

journal_title：PLoS biology

authors： Kalinovsky A,Boukhtouche F,Blazeski R,Bornmann C,Suzuki N,Mason CA,Scheiffele P

更新日期：2011-02-08 00:00:00

abstract：:Synaptic plasticity is widely believed to constitute a key mechanism for modifying functional properties of neuronal networks. This belief implicitly implies, however, that synapses, when not driven to change their characteristics by physiologically relevant stimuli, will maintain these characteristics over time. How ...

journal_title：PLoS biology

authors： Minerbi A,Kahana R,Goldfeld L,Kaufman M,Marom S,Ziv NE

更新日期：2009-06-23 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00

abstract：:Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic treatment remains u...

journal_title：PLoS biology

authors： Tran TQ,Ishak Gabra MB,Lowman XH,Yang Y,Reid MA,Pan M,O'Connor TR,Kong M

更新日期：2017-11-06 00:00:00

abstract：:From early dinosaurs with as many as nine wrist bones, modern birds evolved to develop only four ossifications. Their identity is uncertain, with different labels used in palaeontology and developmental biology. We examined embryos of several species and studied chicken embryos in detail through a new technique allowi...

journal_title：PLoS biology

authors： Botelho JF,Ossa-Fuentes L,Soto-Acuña S,Smith-Paredes D,Nuñez-León D,Salinas-Saavedra M,Ruiz-Flores M,Vargas AO

更新日期：2014-09-30 00:00:00

abstract：:Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the activation of self-reactive B cells; however, the mechanism underlying the negative regulation of ...

journal_title：PLoS biology

authors： Liu C,Bai X,Wu J,Sharma S,Upadhyaya A,Dahlberg CI,Westerberg LS,Snapper SB,Zhao X,Song W

更新日期：2013-11-01 00:00:00

abstract：:The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcript...

journal_title：PLoS biology

authors： Meeske AJ,Rodrigues CD,Brady J,Lim HC,Bernhardt TG,Rudner DZ

更新日期：2016-01-06 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Genome-wide studies of circadian transcription or mRNA translation have been hindered by the presence of heterogeneous cell populations in complex tissues such as the nervous system. We describe here the use of a Drosophila cell-specific translational profiling approach to document the rhythmic "translatome" of neural...

journal_title：PLoS biology

authors： Huang Y,Ainsley JA,Reijmers LG,Jackson FR

更新日期：2013-11-01 00:00:00

abstract：:During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluated the epigenetic landscape of the mouse myometrium during the pregnan...

journal_title：PLoS biology

authors： Shchuka VM,Abatti LE,Hou H,Khader N,Dorogin A,Wilson MD,Shynlova O,Mitchell JA

更新日期：2020-07-15 00:00:00

abstract：:Over the past decade, the high-dose refuge (HDR) strategy, aimed at delaying the evolution of pest resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops, became mandatory in the United States and is being discussed for Europe. However, precopulatory dispersal and the mating rate between residen...

journal_title：PLoS biology

authors： Dalecky A,Ponsard S,Bailey RI,Pélissier C,Bourguet D

更新日期：2006-06-01 00:00:00

abstract：:Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains unclear how these FRC-derived mediators dampen T-cell responses and wheth...

journal_title：PLoS biology

authors： Schaeuble K,Cannelle H,Favre S,Huang HY,Oberle SG,Speiser DE,Zehn D,Luther SA

更新日期：2019-07-15 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

journal_title：PLoS biology

authors： Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

更新日期：2018-09-27 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:This speculative Essay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided evidence that genes are made of DNA. Four imaginary alternate routes to the genetic function of DNA are outlined, each of which highlights different aspects of the actual process of discovery. ...

journal_title：PLoS biology

authors： Cobb M

更新日期：2016-12-22 00:00:00

abstract：:Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...

journal_title：PLoS biology

authors： Hayashi MJ,Ditye T,Harada T,Hashiguchi M,Sadato N,Carlson S,Walsh V,Kanai R

更新日期：2015-09-17 00:00:00

abstract：:A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the...

journal_title：PLoS biology

authors： Landgraf C,Panni S,Montecchi-Palazzi L,Castagnoli L,Schneider-Mergener J,Volkmer-Engert R,Cesareni G

更新日期：2004-01-01 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:The developmental transition from a vegetative to a reproductive phase (i.e., flowering) is timed by the seasonal cue day length or photoperiod in many plant species. Through the photoperiod pathway, inductive day lengths trigger the production of a systemic flowering signal, florigen, to provoke the floral transition...

journal_title：PLoS biology

authors： Gu X,Wang Y,He Y

更新日期：2013-09-01 00:00:00

abstract：:Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the l...

journal_title：PLoS biology

authors： Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

更新日期：2020-11-13 00:00:00