High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis.

abstract：:Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling ...

journal_title：PLoS biology

authors： Lau KS,Cortez-Retamozo V,Philips SR,Pittet MJ,Lauffenburger DA,Haigis KM

更新日期：2012-01-01 00:00:00

abstract：:Protein modifications play a major role for most biological processes in living organisms. Amino-terminal acetylation of proteins is a common modification found throughout the tree of life: the N-terminus of a nascent polypeptide chain becomes co-translationally acetylated, often after the removal of the initiating me...

journal_title：PLoS biology

authors： Goetze S,Qeli E,Mosimann C,Staes A,Gerrits B,Roschitzki B,Mohanty S,Niederer EM,Laczko E,Timmerman E,Lange V,Hafen E,Aebersold R,Vandekerckhove J,Basler K,Ahrens CH,Gevaert K,Brunner E

更新日期：2009-11-01 00:00:00

abstract：:PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...

journal_title：PLoS biology

authors： Fiorini N,Canese K,Starchenko G,Kireev E,Kim W,Miller V,Osipov M,Kholodov M,Ismagilov R,Mohan S,Ostell J,Lu Z

更新日期：2018-08-28 00:00:00

abstract：:Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...

journal_title：PLoS biology

authors： Tonkin-Hill GQ,Trianty L,Noviyanti R,Nguyen HHT,Sebayang BF,Lampah DA,Marfurt J,Cobbold SA,Rambhatla JS,McConville MJ,Rogerson SJ,Brown GV,Day KP,Price RN,Anstey NM,Papenfuss AT,Duffy MF

更新日期：2018-03-12 00:00:00

abstract：:Over the past two decades, neuroscientists have increasingly turned their attention to the question of how the brain implements decisions between differently valued options. This emerging field, called neuroeconomics, has made quick progress in identifying a plethora of brain areas that track or are modulated by rewar...

journal_title：PLoS biology

authors： Stott JJ,Redish AD

更新日期：2015-06-18 00:00:00

abstract：:One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here, we use an unsupervised, systematic approach for associating genes a...

journal_title：PLoS biology

authors： Korbel JO,Doerks T,Jensen LJ,Perez-Iratxeta C,Kaczanowski S,Hooper SD,Andrade MA,Bork P

更新日期：2005-05-01 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:Previously it was shown that male mice, when they encounter female mice or their pheromones, emit ultrasonic vocalizations with frequencies ranging over 30-110 kHz. Here, we show that these vocalizations have the characteristics of song, consisting of several different syllable types, whose temporal sequencing include...

journal_title：PLoS biology

authors： Holy TE,Guo Z

更新日期：2005-12-01 00:00:00

abstract：:The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis. Whereas bacterial conjugation spreads antibiotic resistance, Agrobacterium facilitates efficient interkingdom transfer of ssDNA from...

journal_title：PLoS biology

authors： Grange W,Duckely M,Husale S,Jacob S,Engel A,Hegner M

更新日期：2008-02-01 00:00:00

abstract：:Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. However, recent preclinical and clinical observations of tumor initiati...

journal_title：PLoS biology

authors： Johnson KE,Howard G,Mo W,Strasser MK,Lima EABF,Huang S,Brock A

更新日期：2019-08-05 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00

abstract：:Over the past 3 decades, in a series of studies on some of the most extensively studied toxic chemicals and pollutants, scientists have found that the amount of toxic chemical linked with the development of a disease or death-which is central to determining "safe" or "hazardous" levels-is proportionately greater at th...

journal_title：PLoS biology

authors： Lanphear BP

更新日期：2017-12-19 00:00:00

abstract：:Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary selection. Theoretical and experimental analyses of bacterial chemotaxis suggested that the pathway has been evolutionarily optimized to produce robust output u...

journal_title：PLoS biology

authors： Løvdok L,Bentele K,Vladimirov N,Müller A,Pop FS,Lebiedz D,Kollmann M,Sourjik V

更新日期：2009-08-01 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...

journal_title：PLoS biology

authors： Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CT

更新日期：2019-12-09 00:00:00

abstract：:The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...

journal_title：PLoS biology

authors： Kaufmann K,Muiño JM,Jauregui R,Airoldi CA,Smaczniak C,Krajewski P,Angenent GC

更新日期：2009-04-21 00:00:00

abstract：:The mechanism by which a complex auditory scene is parsed into coherent objects depends on poorly understood interactions between task-driven and stimulus-driven attentional processes. We illuminate these interactions in a simultaneous behavioral-neurophysiological study in which we manipulate participants' attention ...

journal_title：PLoS biology

authors： Elhilali M,Xiang J,Shamma SA,Simon JZ

更新日期：2009-06-01 00:00:00

abstract：:Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, which is loosely defined as a cohort of proteins that perform a dedicated...

journal_title：PLoS biology

authors： Batada NN,Reguly T,Breitkreutz A,Boucher L,Breitkreutz BJ,Hurst LD,Tyers M

更新日期：2006-10-01 00:00:00

abstract：:In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targ...

journal_title：PLoS biology

authors： Lewis TL Jr,Mao T,Arnold DB

更新日期：2011-03-01 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:The organization and the mechanisms of condensation of mitotic chromosomes remain unsolved despite many decades of efforts. The lack of resolution, tight compaction, and the absence of function-specific chromatin labels have been the key technical obstacles. The correlation between DNA sequence composition and its con...

journal_title：PLoS biology

authors： Strukov YG,Sural TH,Kuroda MI,Sedat JW

更新日期：2011-01-11 00:00:00

abstract：:Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeni...

journal_title：PLoS biology

authors： Butts DA,Kanold PO,Shatz CJ

更新日期：2007-03-01 00:00:00

abstract：:A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...

journal_title：PLoS biology

authors： Reindl KM,White AR,Johnson C,Vender B,Slator BM,McClean P

更新日期：2015-04-09 00:00:00

abstract：:The Global Health 2035 report notes that the "grand convergence"--closure of the infectious, maternal, and child mortality gap between rich and poor countries--is dependent on research and development (R&D) of new drugs, vaccines, diagnostics, and other health tools. However, this convergence (and the R&D underpinning...

journal_title：PLoS biology

authors： Moran M

更新日期：2016-03-02 00:00:00

abstract：:All organisms live in temporally fluctuating environments. Theory predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plasticity) underlies adaptation to environments that fluctuate in a predictably alternating fashion over maternal-offspri...

journal_title：PLoS biology

authors： Dey S,Proulx SR,Teotónio H

更新日期：2016-02-24 00:00:00

abstract：:The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp. p45/NRH2/PLAIDD is a p75 homologue and contains a death domain (DD). Here we report th...

journal_title：PLoS biology

authors： Vilar M,Sung TC,Chen Z,García-Carpio I,Fernandez EM,Xu J,Riek R,Lee KF

更新日期：2014-08-05 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally...

journal_title：PLoS biology

authors： Duveau F,Félix MA

更新日期：2012-01-01 00:00:00

abstract：:The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

journal_title：PLoS biology

authors： Hoang HD,Miller MA

更新日期：2017-06-29 00:00:00

abstract：:Virus proliferation involves gene replication inside infected cells and transmission to new target cells. Once positive-strand RNA virus has infected a cell, the viral genome serves as a template for copying ("stay-strategy") or is packaged into a progeny virion that will be released extracellularly ("leave-strategy")...

journal_title：PLoS biology

authors： Iwanami S,Kitagawa K,Ohashi H,Asai Y,Shionoya K,Saso W,Nishioka K,Inaba H,Nakaoka S,Wakita T,Diekmann O,Iwami S,Watashi K

更新日期：2020-07-30 00:00:00