Abstract:
:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neural activity in the hippocampus of freely moving marmosets as they naturally explored a spatial environment to more explicitly investigate this issue. We report place cells in marmoset hippocampus during free navigation that exhibit remarkable parallels to analogous neurons in other mammalian species. Although θ oscillations were prevalent in the marmoset hippocampus, the patterns of activity were notably different than in other taxa. This local field potential oscillation occurred in short bouts (approximately .4 s)-rather than continuously-and was neither significantly modulated by locomotion nor consistently coupled to place-cell activity. These findings suggest that the relationship between place-cell activity and θ oscillations in primate hippocampus during free navigation differs substantially from rodents and paint an intriguing comparative picture regarding the neural basis of spatial navigation across mammals.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CTdoi
10.1371/journal.pbio.3000546subject
Has Abstractpub_date
2019-12-09 00:00:00pages
e3000546issue
12eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-19-01458journal_volume
17pub_type
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