Abstract:
:Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell level or through collective behaviors. Here, we describe a new phenomenon by which P. aeruginosa tolerates antibiotic treatment. In particular, treatment of P. aeruginosa with sublethal concentrations of antibiotics covering all major classes promoted accumulation of the redox-sensitive phenazine pyocyanin (PYO). PYO in turn conferred general tolerance against diverse antibiotics for both P. aeruginosa and other gram-negative and gram-positive bacteria. This property is shared by other redox-active phenazines produced by P. aeruginosa. Our discovery sheds new insights into the physiological functions of phenazines and has implications for designing effective antibiotic treatment protocols.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Zhu K,Chen S,Sysoeva TA,You Ldoi
10.1371/journal.pbio.3000573subject
Has Abstractpub_date
2019-12-16 00:00:00pages
e3000573issue
12eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-18-01097journal_volume
17pub_type
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