High-throughput in vivo analysis of gene expression in Caenorhabditis elegans.

abstract：:Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

journal_title：PLoS biology

authors： Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

更新日期：2019-02-04 00:00:00

abstract：:In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time. ...

journal_title：PLoS biology

authors： Pariente N,PLOS Biology Staff Editors.

更新日期：2020-10-22 00:00:00

abstract：:Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...

journal_title：PLoS biology

authors： André V,Gau C,Scheideler A,Aguilar-Pimentel JA,Amarie OV,Becker L,Garrett L,Hans W,Hölter SM,Janik D,Moreth K,Neff F,Östereicher M,Racz I,Rathkolb B,Rozman J,Bekeredjian R,Graw J,Klingenspor M,Klopstock T,Ollert M

更新日期：2018-04-16 00:00:00

abstract：:The developmental transition from a vegetative to a reproductive phase (i.e., flowering) is timed by the seasonal cue day length or photoperiod in many plant species. Through the photoperiod pathway, inductive day lengths trigger the production of a systemic flowering signal, florigen, to provoke the floral transition...

journal_title：PLoS biology

authors： Gu X,Wang Y,He Y

更新日期：2013-09-01 00:00:00

abstract：:It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffec...

journal_title：PLoS biology

authors： Yao CH,Liu GY,Wang R,Moon SH,Gross RW,Patti GJ

更新日期：2018-03-29 00:00:00

abstract：:Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalami...

journal_title：PLoS biology

authors： Schwab BC,Kase D,Zimnik A,Rosenbaum R,Codianni MG,Rubin JE,Turner RS

更新日期：2020-10-13 00:00:00

abstract：:Cancer research has become a global enterprise, and the number of researchers, as well as the cost for their activities, has skyrocketed. The budget for the National Cancer Institute of the United States National Institutes of Health alone was US$5.2 billion in 2015. Since most of the research is funded by public mone...

journal_title：PLoS biology

authors： Groner BL,Hynes NE

更新日期：2016-09-29 00:00:00

abstract：:Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...

journal_title：PLoS biology

authors： Valdés-Baizabal C,Carbajal GV,Pérez-González D,Malmierca MS

更新日期：2020-06-19 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002454.]. ...

journal_title：PLoS biology

authors： Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

更新日期：2018-03-14 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases. Molecular analyses have recently detailed the lipid antigen recognition strategies utilized by the invariant Vα24-Jα18 TCR rearrangements of iNKT cells, wh...

journal_title：PLoS biology

authors： López-Sagaseta J,Kung JE,Savage PB,Gumperz J,Adams EJ

更新日期：2012-01-01 00:00:00

abstract：:The array of vibrissae on a rat's face is the first stage in a high-resolution tactile sensing system. Progressing from rostral to caudal in any vibrissae row results in an increase in whisker length and thickness. This may, in turn, provide a systematic map of separate tactile channels governed by the mechanical prop...

journal_title：PLoS biology

authors： Gugig E,Sharma H,Azouz R

更新日期：2020-10-22 00:00:00

abstract：:Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to the relatively well-defined shape of bacteria and yeast c...

journal_title：PLoS biology

authors： Picone R,Ren X,Ivanovitch KD,Clarke JD,McKendry RA,Baum B

更新日期：2010-11-16 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatr...

journal_title：PLoS biology

authors： Xu J,Chatterjee M,Baguley TD,Brouillette J,Kurup P,Ghosh D,Kanyo J,Zhang Y,Seyb K,Ononenyi C,Foscue E,Anderson GM,Gresack J,Cuny GD,Glicksman MA,Greengard P,Lam TT,Tautz L,Nairn AC,Ellman JA,Lombroso PJ

更新日期：2014-08-05 00:00:00

abstract：:Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...

journal_title：PLoS biology

authors： Tomassini A,Maris E,Hilt P,Fadiga L,D'Ausilio A

更新日期：2020-10-20 00:00:00

abstract：:Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by...

journal_title：PLoS biology

authors： Thut G

更新日期：2014-12-30 00:00:00

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00

abstract：:The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...

journal_title：PLoS biology

authors： Korkhin Y,Unligil UM,Littlefield O,Nelson PJ,Stuart DI,Sigler PB,Bell SD,Abrescia NG

更新日期：2009-05-01 00:00:00

abstract：:Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

journal_title：PLoS biology

authors： Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

更新日期：2017-06-26 00:00:00

abstract：:Gene expression in eukaryotes is controlled by DNA sequences at promoter and enhancer regions, whose accessibility for binding by regulatory proteins dictates their specific patterns of activity. Here, we identify the protein Zbtb7a as a factor required for inducible changes in accessibility driven by transcription fa...

journal_title：PLoS biology

authors： Ramos Pittol JM,Oruba A,Mittler G,Saccani S,van Essen D

更新日期：2018-05-29 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

journal_title：PLoS biology

authors： Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

更新日期：2018-09-27 00:00:00

abstract：:The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these conditions. Unequivocal proof of such an association, however, requires independent replication of initial positive finding...

journal_title：PLoS biology

authors： Swarbrick MM,Waldenmaier B,Pennacchio LA,Lind DL,Cavazos MM,Geller F,Merriman R,Ustaszewska A,Malloy M,Scherag A,Hsueh WC,Rief W,Mauvais-Jarvis F,Pullinger CR,Kane JP,Dent R,McPherson R,Kwok PY,Hinney A,Hebebrand J

更新日期：2005-09-01 00:00:00

abstract：:Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...

journal_title：PLoS biology

authors： Chao DY,Chen Y,Chen J,Shi S,Chen Z,Wang C,Danku JM,Zhao FJ,Salt DE

更新日期：2014-12-02 00:00:00

abstract：:Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we ident...

journal_title：PLoS biology

authors： Krishnamurthy SR,Janowski AB,Zhao G,Barouch D,Wang D

更新日期：2016-03-24 00:00:00

abstract：:Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...

journal_title：PLoS biology

authors： Gretenkord S,Kostka JK,Hartung H,Watznauer K,Fleck D,Minier-Toribio A,Spehr M,Hanganu-Opatz IL

更新日期：2019-01-31 00:00:00

abstract：:During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kin...

journal_title：PLoS biology

authors： Loc'h J,Blaud M,Réty S,Lebaron S,Deschamps P,Bareille J,Jombart J,Robert-Paganin J,Delbos L,Chardon F,Zhang E,Charenton C,Tollervey D,Leulliot N

更新日期：2014-05-13 00:00:00

abstract：:Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic...

journal_title：PLoS biology

authors： Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK

更新日期：2009-11-01 00:00:00

abstract：:Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...

journal_title：PLoS biology

authors： Ayres JS,Schneider DS

更新日期：2008-12-09 00:00:00

abstract：:The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...

journal_title：PLoS biology

authors： Kaufmann K,Muiño JM,Jauregui R,Airoldi CA,Smaczniak C,Krajewski P,Angenent GC

更新日期：2009-04-21 00:00:00