Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

abstract：:Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....

journal_title：PLoS biology

authors： Qi YJ,Jiao YL,Chen P,Kong JY,Gu BL,Liu K,Feng DD,Zhu YF,Ruan HJ,Lan ZJ,Liu QW,Mi YJ,Guo XQ,Wang M,Liang GF,Lamont RJ,Wang H,Zhou FY,Feng XS,Gao SG

更新日期：2020-09-04 00:00:00

abstract：:The ecologically significant shift in developmental strategy from planktotrophic (feeding) to lecithotrophic (nonfeeding) development in the sea urchin genus Heliocidaris is one of the most comprehensively studied life history transitions in any animal. Although the evolution of lecithotrophy involved substantial chan...

journal_title：PLoS biology

authors： Israel JW,Martik ML,Byrne M,Raff EC,Raff RA,McClay DR,Wray GA

更新日期：2016-03-04 00:00:00

abstract：:Almost all higher organisms, including plants, insects, and mammals, are colonized by complex microbial communities and harbor a microbiome. Emerging studies with plants reveal that these microbiomes are structured and form complex, interconnected microbial networks. Within these networks, different taxa have differen...

journal_title：PLoS biology

authors： van der Heijden MG,Hartmann M

更新日期：2016-02-12 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic treatment remains u...

journal_title：PLoS biology

authors： Tran TQ,Ishak Gabra MB,Lowman XH,Yang Y,Reid MA,Pan M,O'Connor TR,Kong M

更新日期：2017-11-06 00:00:00

abstract：:The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic variation. During sexual genome development, the expressed, somatic macronuclear genome is whittled down to the genic portion of a small fraction (∼5%) of its precursor "silen...

journal_title：PLoS biology

authors： Swart EC,Bracht JR,Magrini V,Minx P,Chen X,Zhou Y,Khurana JS,Goldman AD,Nowacki M,Schotanus K,Jung S,Fulton RS,Ly A,McGrath S,Haub K,Wiggins JL,Storton D,Matese JC,Parsons L,Chang WJ,Bowen MS,Stover NA,Jones T

更新日期：2013-01-01 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

journal_title：PLoS biology

authors： Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

更新日期：2006-05-01 00:00:00

abstract：:The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...

journal_title：PLoS biology

authors： San Pietro E,Capestrano M,Polishchuk EV,DiPentima A,Trucco A,Zizza P,Mariggiò S,Pulvirenti T,Sallese M,Tete S,Mironov AA,Leslie CC,Corda D,Luini A,Polishchuk RS

更新日期：2009-09-01 00:00:00

abstract：:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...

journal_title：PLoS biology

authors： Maletic-Savatic M

更新日期：2017-05-15 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to determine whether gene flow would be facilitated or hampered following ...

journal_title：PLoS biology

authors： Ono J,Gerstein AC,Otto SP

更新日期：2017-01-23 00:00:00

abstract：:There is a widespread concern about the direct and indirect effects of industrial fisheries; this concern is particularly pertinent for so-called "marine protected areas" (MPAs), which should be safeguarded by national and international law. The intertidal flats of the Dutch Wadden Sea are a State Nature Monument and ...

journal_title：PLoS biology

authors： van Gils JA,Piersma T,Dekinga A,Spaans B,Kraan C

更新日期：2006-11-01 00:00:00

abstract：:Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...

journal_title：PLoS biology

authors： Crawley D,Zhang L,Jones EJH,Ahmad J,Oakley B,San José Cáceres A,Charman T,Buitelaar JK,Murphy DGM,Chatham C,den Ouden H,Loth E,EU-AIMS LEAP group.

更新日期：2020-10-27 00:00:00

abstract：:In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time. ...

journal_title：PLoS biology

authors： Pariente N,PLOS Biology Staff Editors.

更新日期：2020-10-22 00:00:00

abstract：:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...

journal_title：PLoS biology

authors： Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CT

更新日期：2019-12-09 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...

journal_title：PLoS biology

authors： Foley E,O'Farrell PH

更新日期：2004-08-01 00:00:00

abstract：:Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinemati...

journal_title：PLoS biology

authors： McGuire LM,Telian G,Laboy-Juárez KJ,Miyashita T,Lee DJ,Smith KA,Feldman DE

更新日期：2016-08-30 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell ...

journal_title：PLoS biology

authors： Zhu K,Chen S,Sysoeva TA,You L

更新日期：2019-12-16 00:00:00

abstract：:Modern whole-organism genome analysis, in combination with biomass estimates, allows us to estimate a lower bound on the total information content in the biosphere: 5.3 × 1031 (±3.6 × 1031) megabases (Mb) of DNA. Given conservative estimates regarding DNA transcription rates, this information content suggests biospher...

journal_title：PLoS biology

authors： Landenmark HK,Forgan DH,Cockell CS

更新日期：2015-06-11 00:00:00

abstract：:Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

journal_title：PLoS biology

authors： Denk W,Horstmann H

更新日期：2004-11-01 00:00:00

abstract：:Instead of combating the acidification of the host cell vacuole, Salmonella acidifies its own cytoplasm in response to the low extracellular pH, helping it to secrete effector molecules. ...

journal_title：PLoS biology

authors： Richardson LA

更新日期：2015-04-14 00:00:00

abstract：:Several strategies have been pursued to increase the extent of exon 7 inclusion during splicing of SMN2 (survival of motor neuron 2) transcripts, for eventual therapeutic use in spinal muscular atrophy (SMA), a genetic neuromuscular disease. Antisense oligonucleotides (ASOs) that target an exon or its flanking splice ...

journal_title：PLoS biology

authors： Hua Y,Vickers TA,Baker BF,Bennett CF,Krainer AR

更新日期：2007-04-01 00:00:00

abstract：:Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular...

journal_title：PLoS biology

authors： Calleja V,Laguerre M,Parker PJ,Larijani B

更新日期：2009-01-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000311.]. ...

journal_title：PLoS biology

authors： Simeon R,Jiang M,Chamoun-Emanuelli AM,Yu H,Zhang Y,Meng R,Peng Z,Jakana J,Zhang J,Feng H,Chen Z

更新日期：2019-10-04 00:00:00

abstract：:Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially i...

journal_title：PLoS biology

authors： Szamecz B,Boross G,Kalapis D,Kovács K,Fekete G,Farkas Z,Lázár V,Hrtyan M,Kemmeren P,Groot Koerkamp MJ,Rutkai E,Holstege FC,Papp B,Pál C

更新日期：2014-08-26 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Here, we have used a graph theory-based systems biology approach to dete...

journal_title：PLoS biology

authors： Novkovic M,Onder L,Cupovic J,Abe J,Bomze D,Cremasco V,Scandella E,Stein JV,Bocharov G,Turley SJ,Ludewig B

更新日期：2016-07-14 00:00:00

abstract：:The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparative analysis of XPD f...

journal_title：PLoS biology

authors： Kuper J,Braun C,Elias A,Michels G,Sauer F,Schmitt DR,Poterszman A,Egly JM,Kisker C

更新日期：2014-09-30 00:00:00

abstract：:Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...

journal_title：PLoS biology

authors： Lacroix R,Mukabana WR,Gouagna LC,Koella JC

更新日期：2005-09-01 00:00:00