Dopamine modulates subcortical responses to surprising sounds.

abstract：:Pruning that selectively eliminates unnecessary axons/dendrites is crucial for sculpting the nervous system during development. During Drosophila metamorphosis, dendrite arborization neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone, whereas mushroom body γ neurons sp...

journal_title：PLoS biology

authors： Wong JJ,Li S,Lim EK,Wang Y,Wang C,Zhang H,Kirilly D,Wu C,Liou YC,Wang H,Yu F

更新日期：2013-09-01 00:00:00

abstract：:The authors of "Relatedness, Conflict, and the Evolution of Eusociality" respond to objections raised by Martin Nowak and Benjamin Allen. ...

journal_title：PLoS biology

authors： Queller DC,Rong S,Liao X

更新日期：2015-04-24 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...

journal_title：PLoS biology

authors： Silva EA,Des Jarlais C,Lindstaedt B,Rotman E,Watkins ES

更新日期：2016-05-06 00:00:00

abstract：:In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...

journal_title：PLoS biology

authors： Stevens SLR,Kuzak M,Martinez C,Moser A,Bleeker P,Galland M

更新日期：2018-11-28 00:00:00

abstract：:Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this function...

journal_title：PLoS biology

authors： Kushnareva Y,Andreyev AY,Kuwana T,Newmeyer DD

更新日期：2012-01-01 00:00:00

abstract：:Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...

journal_title：PLoS biology

authors： Grent-'t-Jong T,Woldorff MG

更新日期：2007-01-01 00:00:00

abstract：:Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional ...

journal_title：PLoS biology

authors： Vachon-Presseau E,Berger SE,Abdullah TB,Griffith JW,Schnitzer TJ,Apkarian AV

更新日期：2019-08-20 00:00:00

abstract：:Microbial endosymbiosis is widespread in animals, with major ecological and evolutionary implications. Successful symbiosis relies on efficient vertical transmission through host generations. However, when symbionts negatively affect host fitness, hosts are expected to evolve suppression of symbiont effects or transmi...

journal_title：PLoS biology

authors： Becking T,Chebbi MA,Giraud I,Moumen B,Laverré T,Caubet Y,Peccoud J,Gilbert C,Cordaux R

更新日期：2019-10-10 00:00:00

abstract：:Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GPCRs) in this dynamic germline regulation. By genome-enabled receptor ...

journal_title：PLoS biology

authors： Saberi A,Jamal A,Beets I,Schoofs L,Newmark PA

更新日期：2016-05-10 00:00:00

abstract：:RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to th...

journal_title：PLoS biology

authors： Simmer F,Moorman C,van der Linden AM,Kuijk E,van den Berghe PV,Kamath RS,Fraser AG,Ahringer J,Plasterk RH

更新日期：2003-10-01 00:00:00

abstract：:CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated from injured Pax7( ...

journal_title：PLoS biology

authors： Seale P,Ishibashi J,Scimè A,Rudnicki MA

更新日期：2004-05-01 00:00:00

abstract：:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

journal_title：PLoS biology

authors： Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

更新日期：2021-01-04 00:00:00

abstract：:DEAD-box proteins are ubiquitous regulators of RNA biology. While commonly dubbed "helicases," their activities also include duplex annealing, adenosine triphosphate (ATP)-dependent RNA binding, and RNA-protein complex remodeling. Rok1, an essential DEAD-box protein, and its cofactor Rrp5 are required for ribosome ass...

journal_title：PLoS biology

authors： Khoshnevis S,Askenasy I,Johnson MC,Dattolo MD,Young-Erdos CL,Stroupe ME,Karbstein K

更新日期：2016-06-09 00:00:00

abstract：:Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...

journal_title：PLoS biology

authors： Breckenridge RA,Piotrowska I,Ng KE,Ragan TJ,West JA,Kotecha S,Towers N,Bennett M,Kienesberger PC,Smolenski RT,Siddall HK,Offer JL,Mocanu MM,Yelon DM,Dyck JR,Griffin JL,Abramov AY,Gould AP,Mohun TJ

更新日期：2013-09-01 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated wh...

journal_title：PLoS biology

authors： Menacho-Márquez M,García-Escudero R,Ojeda V,Abad A,Delgado P,Costa C,Ruiz S,Alarcón B,Paramio JM,Bustelo XR

更新日期：2013-07-01 00:00:00

abstract：:A new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both excitatory and inhibitory synapses in the brain, but by different mechanisms. Read the accompanying Research Article. ...

journal_title：PLoS biology

authors： Robinson R

更新日期：2015-05-21 00:00:00

abstract：:Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and p...

journal_title：PLoS biology

authors： Nuismer SL,Otto SP

更新日期：2005-07-01 00:00:00

abstract：:Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain l...

journal_title：PLoS biology

authors： Jessberger S,Aigner S,Clemenson GD Jr,Toni N,Lie DC,Karalay O,Overall R,Kempermann G,Gage FH

更新日期：2008-11-11 00:00:00

abstract：:Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. However, recent preclinical and clinical observations of tumor initiati...

journal_title：PLoS biology

authors： Johnson KE,Howard G,Mo W,Strasser MK,Lima EABF,Huang S,Brock A

更新日期：2019-08-05 00:00:00

abstract：:Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differ...

journal_title：PLoS biology

authors： Andressoo JO,Jans J,de Wit J,Coin F,Hoogstraten D,van de Ven M,Toussaint W,Huijmans J,Thio HB,van Leeuwen WJ,de Boer J,Egly JM,Hoeijmakers JH,van der Horst GT,Mitchell JR

更新日期：2006-10-01 00:00:00

abstract：:There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo. Here, by using the multi-protein tip complex of the mannose-binding type 1 fimb...

journal_title：PLoS biology

authors： Aprikian P,Interlandi G,Kidd BA,Le Trong I,Tchesnokova V,Yakovenko O,Whitfield MJ,Bullitt E,Stenkamp RE,Thomas WE,Sokurenko EV

更新日期：2011-05-01 00:00:00

abstract：:Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...

journal_title：PLoS biology

authors： Crawley D,Zhang L,Jones EJH,Ahmad J,Oakley B,San José Cáceres A,Charman T,Buitelaar JK,Murphy DGM,Chatham C,den Ouden H,Loth E,EU-AIMS LEAP group.

更新日期：2020-10-27 00:00:00

abstract：:The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...

journal_title：PLoS biology

authors： Kalinovsky A,Boukhtouche F,Blazeski R,Bornmann C,Suzuki N,Mason CA,Scheiffele P

更新日期：2011-02-08 00:00:00

abstract：:Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...

journal_title：PLoS biology

authors： Colón-Thillet R,Hsieh E,Graf L,McLaughlin RN Jr,Young JM,Kochs G,Emerman M,Malik HS

更新日期：2019-10-01 00:00:00

abstract：:Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

journal_title：PLoS biology

authors： Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

更新日期：2019-02-04 00:00:00

abstract：:In Amazonian tropical forests, recent studies have reported increases in aboveground biomass and in primary productivity, as well as shifts in plant species composition favouring fast-growing species over slow-growing ones. This pervasive alteration of mature tropical forests was attributed to global environmental cha...

journal_title：PLoS biology

authors： Chave J,Condit R,Muller-Landau HC,Thomas SC,Ashton PS,Bunyavejchewin S,Co LL,Dattaraja HS,Davies SJ,Esufali S,Ewango CE,Feeley KJ,Foster RB,Gunatilleke N,Gunatilleke S,Hall P,Hart TB,Hernández C,Hubbell SP,Itoh A,

更新日期：2008-03-04 00:00:00

abstract：:Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

journal_title：PLoS biology

authors： Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

更新日期：2008-12-23 00:00:00

abstract：:Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...

journal_title：PLoS biology

authors： Hipfner DR,Cohen SM

更新日期：2003-11-01 00:00:00