The cell cycle-regulated genes of Schizosaccharomyces pombe.

abstract：:An increasing number of publishers and funding agencies require public data archiving (PDA) in open-access databases. PDA has obvious group benefits for the scientific community, but many researchers are reluctant to share their data publicly because of real or perceived individual costs. Improving participation in PD...

journal_title：PLoS biology

authors： Roche DG,Lanfear R,Binning SA,Haff TM,Schwanz LE,Cain KE,Kokko H,Jennions MD,Kruuk LE

更新日期：2014-01-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2001951.]. ...

journal_title：PLoS biology

authors： Di Biase S,Shim HS,Kim KH,Vinciguerra M,Rappa F,Wei M,Brandhorst S,Cappello F,Mirzaei H,Lee C,Longo VD

更新日期：2017-05-01 00:00:00

abstract：:Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas...

journal_title：PLoS biology

authors： Miller WL,Auchus RJ

更新日期：2019-04-03 00:00:00

abstract：:Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...

journal_title：PLoS biology

authors： Sojo V,Pomiankowski A,Lane N

更新日期：2014-08-12 00:00:00

abstract：:A recent report by the Institute of Medicine leaves few urgent reasons standing for the continued use of chimpanzees in biomedical research. It is high time to think about their retirement, Frans de Waal argues, without neglecting prospects for non-invasive research on behavior, cognition, and genetics. ...

journal_title：PLoS biology

authors： de Waal FB

更新日期：2012-01-01 00:00:00

abstract：:Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding mo...

journal_title：PLoS biology

authors： Schoofs A,Hückesfeld S,Schlegel P,Miroschnikow A,Peters M,Zeymer M,Spieß R,Chiang AS,Pankratz MJ

更新日期：2014-06-24 00:00:00

abstract：:Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...

journal_title：PLoS biology

authors： Breckenridge RA,Piotrowska I,Ng KE,Ragan TJ,West JA,Kotecha S,Towers N,Bennett M,Kienesberger PC,Smolenski RT,Siddall HK,Offer JL,Mocanu MM,Yelon DM,Dyck JR,Griffin JL,Abramov AY,Gould AP,Mohun TJ

更新日期：2013-09-01 00:00:00

abstract：:Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus. In yeast, a large set of UPR target genes has been experimentally determined, but the previo...

journal_title：PLoS biology

authors： Patil CK,Li H,Walter P

更新日期：2004-08-01 00:00:00

abstract：:A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...

journal_title：PLoS biology

authors： Bahramisharif A,Jensen O,Jacobs J,Lisman J

更新日期：2018-08-15 00:00:00

abstract：:The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these conditions. Unequivocal proof of such an association, however, requires independent replication of initial positive finding...

journal_title：PLoS biology

authors： Swarbrick MM,Waldenmaier B,Pennacchio LA,Lind DL,Cavazos MM,Geller F,Merriman R,Ustaszewska A,Malloy M,Scherag A,Hsueh WC,Rief W,Mauvais-Jarvis F,Pullinger CR,Kane JP,Dent R,McPherson R,Kwok PY,Hinney A,Hebebrand J

更新日期：2005-09-01 00:00:00

abstract：:Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by...

journal_title：PLoS biology

authors： Thut G

更新日期：2014-12-30 00:00:00

abstract：:Rapid colour change is a remarkable natural phenomenon that has evolved in several vertebrate and invertebrate lineages. The two principal explanations for the evolution of this adaptive strategy are (1) natural selection for crypsis (camouflage) against a range of different backgrounds and (2) selection for conspicuo...

journal_title：PLoS biology

authors： Stuart-Fox D,Moussalli A

更新日期：2008-01-01 00:00:00

abstract：:Self-incompatibility (SI) is the flowering plant reproductive system in which self pollen tube growth is inhibited, thereby preventing self-fertilization. SI has evolved independently in several different flowering plant lineages. In all Brassicaceae species in which the molecular basis of SI has been investigated in ...

journal_title：PLoS biology

authors： Chantha SC,Herman AC,Platts AE,Vekemans X,Schoen DJ

更新日期：2013-01-01 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:5-hydroxymethylcytosine (5hmC) is the most prevalent intermediate on the oxidative DNA demethylation pathway and is implicated in regulation of embryogenesis, neurological processes, and cancerogenesis. Profiling of this relatively scarce genomic modification in clinical samples requires cost-effective high-resolution...

journal_title：PLoS biology

authors： Gibas P,Narmontė M,Staševskij Z,Gordevičius J,Klimašauskas S,Kriukienė E

更新日期：2020-04-10 00:00:00

abstract：:Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells. Here, we show that Escherichia coli cell lineages exhibit comparable pa...

journal_title：PLoS biology

authors： Proenca AM,Rang CU,Qiu A,Shi C,Chao L

更新日期：2019-05-23 00:00:00

abstract：:Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...

journal_title：PLoS biology

authors： Ayres JS,Schneider DS

更新日期：2008-12-09 00:00:00

abstract：:Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

journal_title：PLoS biology

authors： Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

更新日期：2017-06-26 00:00:00

abstract：:microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to precursor miRNA (pre-m...

journal_title：PLoS biology

authors： Förstemann K,Tomari Y,Du T,Vagin VV,Denli AM,Bratu DP,Klattenhoff C,Theurkauf WE,Zamore PD

更新日期：2005-07-01 00:00:00

abstract：:While multiple studies have reported the accelerated evolution of brain gene expression in the human lineage, the mechanisms underlying such changes are unknown. Here, we address this issue from a developmental perspective, by analyzing mRNA and microRNA (miRNA) expression in two brain regions within macaques, chimpan...

journal_title：PLoS biology

authors： Somel M,Liu X,Tang L,Yan Z,Hu H,Guo S,Jiang X,Zhang X,Xu G,Xie G,Li N,Hu Y,Chen W,Pääbo S,Khaitovich P

更新日期：2011-12-01 00:00:00

abstract：:The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the specificity of the ...

journal_title：PLoS biology

authors： Levinson NM,Kuchment O,Shen K,Young MA,Koldobskiy M,Karplus M,Cole PA,Kuriyan J

更新日期：2006-05-01 00:00:00

abstract：:The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcript...

journal_title：PLoS biology

authors： Meeske AJ,Rodrigues CD,Brady J,Lim HC,Bernhardt TG,Rudner DZ

更新日期：2016-01-06 00:00:00

abstract：:Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

journal_title：PLoS biology

authors： Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

更新日期：2006-05-01 00:00:00

abstract：:Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

journal_title：PLoS biology

authors： Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

更新日期：2019-02-04 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalam...

journal_title：PLoS biology

authors： Zhang H,Zhang G,Gonzalez FJ,Park SM,Cai D

更新日期：2011-07-01 00:00:00

abstract：:One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here, we use an unsupervised, systematic approach for associating genes a...

journal_title：PLoS biology

authors： Korbel JO,Doerks T,Jensen LJ,Perez-Iratxeta C,Kaczanowski S,Hooper SD,Andrade MA,Bork P

更新日期：2005-05-01 00:00:00

abstract：:Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment i...

journal_title：PLoS biology

authors： Hirst J,Barlow LD,Francisco GC,Sahlender DA,Seaman MN,Dacks JB,Robinson MS

更新日期：2011-10-01 00:00:00

abstract：:As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexpression in females ...

journal_title：PLoS biology

authors： Julien P,Brawand D,Soumillon M,Necsulea A,Liechti A,Schütz F,Daish T,Grützner F,Kaessmann H

更新日期：2012-01-01 00:00:00

abstract：:Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-embryos display an identical phenotype, indicating that these ce...

journal_title：PLoS biology

authors： Lee KM,Wilson GJ,Pingen M,Fukuoka A,Hansell CAH,Bartolini R,Medina-Ruiz L,Graham GJ

更新日期：2019-05-29 00:00:00

abstract：:Gene expression in eukaryotes is controlled by DNA sequences at promoter and enhancer regions, whose accessibility for binding by regulatory proteins dictates their specific patterns of activity. Here, we identify the protein Zbtb7a as a factor required for inducible changes in accessibility driven by transcription fa...

journal_title：PLoS biology

authors： Ramos Pittol JM,Oruba A,Mittler G,Saccani S,van Essen D

更新日期：2018-05-29 00:00:00