Abstract:
:Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evidence also suggests that chromosomes may be specifically positioned within the nucleus; however, the nature of this organization and how it is achieved are not yet fully understood. To examine whether gene regulation is related to a discernible pattern of genomic organization, we analyzed the linear arrangement of co-regulated genes along chromosomes and determined the organization of chromosomes during the differentiation of a hematopoietic progenitor to erythroid and neutrophil cell types. Our analysis reveals that there is a significant tendency for co-regulated genes to be proximal, which is related to the association of homologous chromosomes and the spatial juxtaposition of lineage-specific gene domains. We suggest that proximity in the form of chromosomal gene distribution and homolog association may be the basis for organizing the genome for coordinate gene regulation during cellular differentiation.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Kosak ST,Scalzo D,Alworth SV,Li F,Palmer S,Enver T,Lee JS,Groudine Mdoi
10.1371/journal.pbio.0050309subject
Has Abstractpub_date
2007-11-01 00:00:00pages
e309issue
11eissn
1544-9173issn
1545-7885pii
06-PLBI-RA-1214journal_volume
5pub_type
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