Abstract:
:Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain of VosA is a novel DNA-binding motif that specifically recognizes an 11-nucleotide consensus sequence consisting of two motifs in the promoters of key developmental regulatory genes. The crystal structure analysis of the VosA velvet domain revealed an unforeseen structural similarity with the Rel homology domain (RHD) of the mammalian transcription factor NF-κB. Based on this structural similarity several conserved amino acid residues present in all velvet domains have been identified and shown to be essential for the DNA binding ability of VosA. The velvet domain is also involved in dimer formation as seen in the solved crystal structures of the VosA homodimer and the VosA-VelB heterodimer. These findings suggest that defence mechanisms of both fungi and animals might be governed by structurally related DNA-binding transcription factors.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner Rdoi
10.1371/journal.pbio.1001750subject
Has Abstractpub_date
2013-12-01 00:00:00pages
e1001750issue
12eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-13-02766journal_volume
11pub_type
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