Explaining the linguistic diversity of Sahul using population models.

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...

journal_title：PLoS biology

authors： Lu W,Hu Y,Chen G,Chen Z,Zhang H,Wang F,Feng L,Pelicano H,Wang H,Keating MJ,Liu J,McKeehan W,Wang H,Luo Y,Huang P

更新日期：2017-12-11 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials ...

journal_title：PLoS biology

authors： Jang J,Han D,Golkaram M,Audouard M,Liu G,Bridges D,Hellander S,Chialastri A,Dey SS,Petzold LR,Kosik KS

更新日期：2019-09-26 00:00:00

abstract：:Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...

journal_title：PLoS biology

authors： Fortna A,Kim Y,MacLaren E,Marshall K,Hahn G,Meltesen L,Brenton M,Hink R,Burgers S,Hernandez-Boussard T,Karimpour-Fard A,Glueck D,McGavran L,Berry R,Pollack J,Sikela JM

更新日期：2004-07-01 00:00:00

abstract：:Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have...

journal_title：PLoS biology

authors： Hershberg R,Lipatov M,Small PM,Sheffer H,Niemann S,Homolka S,Roach JC,Kremer K,Petrov DA,Feldman MW,Gagneux S

更新日期：2008-12-16 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. He...

journal_title：PLoS biology

authors： Ni X,Zhang YE,Nègre N,Chen S,Long M,White KP

更新日期：2012-01-01 00:00:00

abstract：:When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...

journal_title：PLoS biology

authors： Bays PM,Flanagan JR,Wolpert DM

更新日期：2006-02-01 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2001154.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2017-05-09 00:00:00

abstract：:Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

journal_title：PLoS biology

authors： Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

更新日期：2020-12-07 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain l...

journal_title：PLoS biology

authors： Jessberger S,Aigner S,Clemenson GD Jr,Toni N,Lie DC,Karalay O,Overall R,Kempermann G,Gage FH

更新日期：2008-11-11 00:00:00

abstract：:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...

journal_title：PLoS biology

authors： Maletic-Savatic M

更新日期：2017-05-15 00:00:00

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex I are involved in a wide range of degenerative disorders. Recent...

journal_title：PLoS biology

authors： Dröse S,Krack S,Sokolova L,Zwicker K,Barth HD,Morgner N,Heide H,Steger M,Nübel E,Zickermann V,Kerscher S,Brutschy B,Radermacher M,Brandt U

更新日期：2011-08-01 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

journal_title：PLoS biology

authors： Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

更新日期：2003-12-01 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:Protein modifications play a major role for most biological processes in living organisms. Amino-terminal acetylation of proteins is a common modification found throughout the tree of life: the N-terminus of a nascent polypeptide chain becomes co-translationally acetylated, often after the removal of the initiating me...

journal_title：PLoS biology

authors： Goetze S,Qeli E,Mosimann C,Staes A,Gerrits B,Roschitzki B,Mohanty S,Niederer EM,Laczko E,Timmerman E,Lange V,Hafen E,Aebersold R,Vandekerckhove J,Basler K,Ahrens CH,Gevaert K,Brunner E

更新日期：2009-11-01 00:00:00

abstract：:Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...

journal_title：PLoS biology

authors： Tomassini A,Maris E,Hilt P,Fadiga L,D'Ausilio A

更新日期：2020-10-20 00:00:00

abstract：:Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the prevalence of phylosymbiosis and its functional significance under highly controlled conditions b...

journal_title：PLoS biology

authors： Brooks AW,Kohl KD,Brucker RM,van Opstal EJ,Bordenstein SR

更新日期：2016-11-18 00:00:00

abstract：:The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

journal_title：PLoS biology

authors： Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

更新日期：2013-01-01 00:00:00

abstract：:Both endocrine and exocrine pancreatic cells arise from pancreatic-duodenal homeobox 1 (pdx1)-positive progenitors. The molecular mechanisms controlling cell fate determination and subsequent proliferation, however, are poorly understood. Unlike endocrine cells, less is known about exocrine cell specification. We repo...

journal_title：PLoS biology

authors： Jiang Z,Song J,Qi F,Xiao A,An X,Liu NA,Zhu Z,Zhang B,Lin S

更新日期：2008-11-25 00:00:00

abstract：:In photosynthetic organisms, feedback dissipation of excess absorbed light energy balances harvesting of light with metabolic energy consumption. This mechanism prevents photodamage caused by reactive oxygen species produced by the reaction of chlorophyll (Chl) triplet states with O₂. Plants have been found to perform...

journal_title：PLoS biology

authors： Bonente G,Ballottari M,Truong TB,Morosinotto T,Ahn TK,Fleming GR,Niyogi KK,Bassi R

更新日期：2011-01-18 00:00:00

abstract：:Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...

journal_title：PLoS biology

authors： Fatsis-Kavalopoulos N,Roemhild R,Tang PC,Kreuger J,Andersson DI

更新日期：2020-09-17 00:00:00

abstract：:The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparative analysis of XPD f...

journal_title：PLoS biology

authors： Kuper J,Braun C,Elias A,Michels G,Sauer F,Schmitt DR,Poterszman A,Egly JM,Kisker C

更新日期：2014-09-30 00:00:00

abstract：:Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional ...

journal_title：PLoS biology

authors： Vachon-Presseau E,Berger SE,Abdullah TB,Griffith JW,Schnitzer TJ,Apkarian AV

更新日期：2019-08-20 00:00:00

abstract：:Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analys...

journal_title：PLoS biology

authors： McGrath TM,Spreckley E,Rodriguez AF,Viscomi C,Alamshah A,Akalestou E,Murphy KG,Jones NS

更新日期：2019-12-05 00:00:00

abstract：:Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

journal_title：PLoS biology

authors： Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

更新日期：2017-06-26 00:00:00