Correction: Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cues.


:[This corrects the article DOI: 10.1371/journal.pbio.2001154.].


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2017-05-09 00:00:00














  • From dinosaurs to modern bird diversity: extending the time scale of adaptive radiation.

    abstract::What explains why some groups of organisms, like birds, are so species rich? And what explains their extraordinary ecological diversity, ranging from large, flightless birds to small migratory species that fly thousand of kilometers every year? These and similar questions have spurred great interest in adaptive radiat...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Moen D,Morlon H

    更新日期:2014-05-06 00:00:00

  • Breast Cancer Patients Have Greatly Benefited from the Progress in Molecular Oncology.

    abstract::Cancer research has become a global enterprise, and the number of researchers, as well as the cost for their activities, has skyrocketed. The budget for the National Cancer Institute of the United States National Institutes of Health alone was US$5.2 billion in 2015. Since most of the research is funded by public mone...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Groner BL,Hynes NE

    更新日期:2016-09-29 00:00:00

  • Developing a modern data workflow for regularly updated data.

    abstract::Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Yenni GM,Christensen EM,Bledsoe EK,Supp SR,Diaz RM,White EP,Ernest SKM

    更新日期:2019-01-29 00:00:00

  • Identification of FAM173B as a protein methyltransferase promoting chronic pain.

    abstract::Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Willemen HLDM,Kavelaars A,Prado J,Maas M,Versteeg S,Nellissen LJJ,Tromp J,Gonzalez Cano R,Zhou W,Jakobsson ME,Małecki J,Posthuma G,Habib AM,Heijnen CJ,Falnes PØ,Eijkelkamp N

    更新日期:2018-02-14 00:00:00

  • Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant.

    abstract::Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic g...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Levy SF,Ziv N,Siegal ML

    更新日期:2012-01-01 00:00:00

  • Shape invariant coding of motion direction in somatosensory cortex.

    abstract::Invariant representations of stimulus features are thought to play an important role in producing stable percepts of objects. In the present study, we assess the invariance of neural representations of tactile motion direction with respect to other stimulus properties. To this end, we record the responses evoked in in...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Pei YC,Hsiao SS,Craig JC,Bensmaia SJ

    更新日期:2010-02-02 00:00:00

  • The "backdoor pathway" of androgen synthesis in human male sexual development.

    abstract::Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas...

    journal_title:PLoS biology

    pub_type: 评论,杂志文章


    authors: Miller WL,Auchus RJ

    更新日期:2019-04-03 00:00:00

  • Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication.

    abstract::Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Pejchal R,Ludwig ML

    更新日期:2005-02-01 00:00:00

  • Polarized Exocytosis Induces Compensatory Endocytosis by Sec4p-Regulated Cortical Actin Polymerization.

    abstract::Polarized growth is maintained by both polarized exocytosis, which transports membrane components to specific locations on the cell cortex, and endocytosis, which retrieves these components before they can diffuse away. Despite functional links between these two transport pathways, they are generally considered to be ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Johansen J,Alfaro G,Beh CT

    更新日期:2016-08-15 00:00:00

  • Porphyromonas gingivalis promotes progression of esophageal squamous cell cancer via TGFβ-dependent Smad/YAP/TAZ signaling.

    abstract::Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Qi YJ,Jiao YL,Chen P,Kong JY,Gu BL,Liu K,Feng DD,Zhu YF,Ruan HJ,Lan ZJ,Liu QW,Mi YJ,Guo XQ,Wang M,Liang GF,Lamont RJ,Wang H,Zhou FY,Feng XS,Gao SG

    更新日期:2020-09-04 00:00:00

  • Resistance evolution to Bt crops: predispersal mating of European corn borers.

    abstract::Over the past decade, the high-dose refuge (HDR) strategy, aimed at delaying the evolution of pest resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops, became mandatory in the United States and is being discussed for Europe. However, precopulatory dispersal and the mating rate between residen...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Dalecky A,Ponsard S,Bailey RI,Pélissier C,Bourguet D

    更新日期:2006-06-01 00:00:00

  • Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria.

    abstract::Animals live together with diverse bacteria that can impact their biology. In Drosophila melanogaster, gut-associated bacterial communities are relatively simple in composition but also have a strong impact on host development and physiology. It is generally assumed that gut bacteria in D. melanogaster are transient a...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Pais IS,Valente RS,Sporniak M,Teixeira L

    更新日期:2018-07-05 00:00:00

  • A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.

    abstract::Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a microscopy-based genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins required for centriole duplication and mitotic PCM recruitment. We analysed 92% of the Droso...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Dobbelaere J,Josué F,Suijkerbuijk S,Baum B,Tapon N,Raff J

    更新日期:2008-09-16 00:00:00

  • Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.

    abstract::The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: San Pietro E,Capestrano M,Polishchuk EV,DiPentima A,Trucco A,Zizza P,Mariggiò S,Pulvirenti T,Sallese M,Tete S,Mironov AA,Leslie CC,Corda D,Luini A,Polishchuk RS

    更新日期:2009-09-01 00:00:00

  • Smooth muscle tension induces invasive remodeling of the zebrafish intestine.

    abstract::The signals that initiate cell invasion are not well understood, but there is increasing evidence that extracellular physical signals play an important role. Here we show that epithelial cell invasion in the intestine of zebrafish meltdown (mlt) mutants arises in response to unregulated contractile tone in the surroun...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Seiler C,Davuluri G,Abrams J,Byfield FJ,Janmey PA,Pack M

    更新日期:2012-01-01 00:00:00

  • A new yeast poly(A) polymerase complex involved in RNA quality control.

    abstract::Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors. The yeast protein Trf4p has been implicated in a quality control pathway that leads to the polyadenylation and subsequent exosome-...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Vanácová S,Wolf J,Martin G,Blank D,Dettwiler S,Friedlein A,Langen H,Keith G,Keller W

    更新日期:2005-06-01 00:00:00

  • Harvesting the promising fruits of genomics: applying genome sequencing technologies to crop breeding.

    abstract::Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Varshney RK,Terauchi R,McCouch SR

    更新日期:2014-06-10 00:00:00

  • Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.

    abstract::Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

    更新日期:2020-12-07 00:00:00

  • Active listening for spatial orientation in a complex auditory scene.

    abstract::To successfully negotiate a complex environment, an animal must control the timing of motor behaviors in coordination with dynamic sensory information. Here, we report on adaptive temporal control of vocal-motor behavior in an echolocating bat, Eptesicus fuscus, as it captured tethered insects close to background vege...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Moss CF,Bohn K,Gilkenson H,Surlykke A

    更新日期:2006-04-01 00:00:00

  • Microstructural and functional gradients are increasingly dissociated in transmodal cortices.

    abstract::While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

    更新日期:2019-05-20 00:00:00

  • Haves and have nots must find a better way: The case for open scientific hardware.

    abstract::Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Maia Chagas A

    更新日期:2018-09-27 00:00:00

  • Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models.

    abstract::A large fraction of genome variation between individuals is comprised of submicroscopic copy number variation of genomic DNA segments. We assessed the relative contribution of structural changes and gene dosage alterations on phenotypic outcomes with mouse models of Smith-Magenis and Potocki-Lupski syndromes. We pheno...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ricard G,Molina J,Chrast J,Gu W,Gheldof N,Pradervand S,Schütz F,Young JI,Lupski JR,Reymond A,Walz K

    更新日期:2010-11-23 00:00:00

  • A novel unsupervised analysis of electrophysiological signals reveals new sleep substages in mice.

    abstract::Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

    更新日期:2018-05-29 00:00:00

  • Stratus not altocumulus: a new view of the yeast protein interaction network.

    abstract::Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, which is loosely defined as a cohort of proteins that perform a dedicated...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Batada NN,Reguly T,Breitkreutz A,Boucher L,Breitkreutz BJ,Hurst LD,Tyers M

    更新日期:2006-10-01 00:00:00

  • How to live with the enemy: understanding tolerance to parasites.

    abstract::How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance--the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively we...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Råberg L

    更新日期:2014-11-04 00:00:00

  • Cadherin-2 controls directional chain migration of cerebellar granule neurons.

    abstract::Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip has been reported in many vertebrates. However, the knowledge about the subcellular dynamics and molecular mechanisms regulating directional neuronal migration in vivo is just beginning to emerge. Here we show by time-lapse ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Rieger S,Senghaas N,Walch A,Köster RW

    更新日期:2009-11-01 00:00:00

  • Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns.

    abstract::The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Kelsch W,Mosley CP,Lin CW,Lois C

    更新日期:2007-11-01 00:00:00

  • Functional brain imaging in the clinical assessment of consciousness.

    abstract::Recent findings suggest that functional brain imaging might be used to identify consciousness in patients diagnosed with persistent vegetative state and minimally conscious state. Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats. ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Rafii MS,Brewer JB

    更新日期:2010-11-30 00:00:00

  • Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

    abstract::Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to iden...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Riethmueller S,Somasundaram P,Ehlers JC,Hung CW,Flynn CM,Lokau J,Agthe M,Düsterhöft S,Zhu Y,Grötzinger J,Lorenzen I,Koudelka T,Yamamoto K,Pickhinke U,Wichert R,Becker-Pauly C,Rädisch M,Albrecht A,Hessefort M,Stahnke

    更新日期:2017-01-06 00:00:00

  • NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

    abstract::Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the d...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Liu P,Dodson M,Fang D,Chapman E,Zhang DD

    更新日期:2020-02-13 00:00:00