CombiANT: Antibiotic interaction testing made easy.

abstract：:The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

journal_title：PLoS biology

authors： Hoang HD,Miller MA

更新日期：2017-06-29 00:00:00

abstract：:The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understandi...

journal_title：PLoS biology

authors： Murphy AC,Muldoon SF,Baker D,Lastowka A,Bennett B,Yang M,Bassett DS

更新日期：2018-01-18 00:00:00

abstract：:Citizen science is mainstream: millions of people contribute data to a growing array of citizen science projects annually, forming massive datasets that will drive research for years to come. Many citizen science projects implement a "leaderboard" framework, ranking the contributions based on number of records or spec...

journal_title：PLoS biology

authors： Callaghan CT,Rowley JJL,Cornwell WK,Poore AGB,Major RE

更新日期：2019-06-27 00:00:00

abstract：:Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have...

journal_title：PLoS biology

authors： Hershberg R,Lipatov M,Small PM,Sheffer H,Niemann S,Homolka S,Roach JC,Kremer K,Petrov DA,Feldman MW,Gagneux S

更新日期：2008-12-16 00:00:00

abstract：:Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in neural coding and modulates information transfer between cortic...

journal_title：PLoS biology

authors： Lowet E,Gips B,Roberts MJ,De Weerd P,Jensen O,van der Eerden J

更新日期：2018-05-31 00:00:00

abstract：:Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently...

journal_title：PLoS biology

authors： Wu Z,Pang N,Zhang Y,Chen H,Peng Y,Fu J,Wei Q

更新日期：2020-12-28 00:00:00

abstract：:Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in ...

journal_title：PLoS biology

authors： Lieberman RL

更新日期：2019-04-22 00:00:00

abstract：:DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not known how they disrupt RNA tertiary structure. Here, we use sing...

journal_title：PLoS biology

authors： Pan C,Potratz JP,Cannon B,Simpson ZB,Ziehr JL,Tijerina P,Russell R

更新日期：2014-10-28 00:00:00

abstract：:Progress in science often begins with verbal hypotheses meant to explain why certain biological phenomena exist. An important purpose of mathematical models in evolutionary research, as in many other fields, is to act as “proof-of-concept” tests of the logic in verbal explanations, paralleling the way in which empiric...

journal_title：PLoS biology

authors： Servedio MR,Brandvain Y,Dhole S,Fitzpatrick CL,Goldberg EE,Stern CA,Van Cleve J,Yeh DJ

更新日期：2014-12-09 00:00:00

abstract：:Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...

journal_title：PLoS biology

authors： Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner R

更新日期：2013-12-01 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...

journal_title：PLoS biology

authors： Korkhin Y,Unligil UM,Littlefield O,Nelson PJ,Stuart DI,Sigler PB,Bell SD,Abrescia NG

更新日期：2009-05-01 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:Unc-51-like autophagy activating kinase 1 (ULK1)-autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions. However, their phospho-regul...

journal_title：PLoS biology

authors： Li Z,Tian X,Ji X,Wang J,Chen H,Wang D,Zhang X

更新日期：2020-06-09 00:00:00

abstract：:Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...

journal_title：PLoS biology

authors： Gretenkord S,Kostka JK,Hartung H,Watznauer K,Fleck D,Minier-Toribio A,Spehr M,Hanganu-Opatz IL

更新日期：2019-01-31 00:00:00

abstract：:The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men....

journal_title：PLoS biology

authors： Balaresque P,Bowden GR,Adams SM,Leung HY,King TE,Rosser ZH,Goodwin J,Moisan JP,Richard C,Millward A,Demaine AG,Barbujani G,Previderè C,Wilson IJ,Tyler-Smith C,Jobling MA

更新日期：2010-01-19 00:00:00

abstract：:Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...

journal_title：PLoS biology

authors： Augustin H,McGourty K,Allen MJ,Madem SK,Adcott J,Kerr F,Wong CT,Vincent A,Godenschwege T,Boucrot E,Partridge L

更新日期：2017-09-13 00:00:00

abstract：:Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeni...

journal_title：PLoS biology

authors： Butts DA,Kanold PO,Shatz CJ

更新日期：2007-03-01 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...

journal_title：PLoS biology

authors： Colón-Thillet R,Hsieh E,Graf L,McLaughlin RN Jr,Young JM,Kochs G,Emerman M,Malik HS

更新日期：2019-10-01 00:00:00

abstract：:A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...

journal_title：PLoS biology

authors： Reindl KM,White AR,Johnson C,Vender B,Slator BM,McClean P

更新日期：2015-04-09 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints du...

journal_title：PLoS biology

authors： Green AA,Kennaway JR,Hanna AI,Bangham JA,Coen E

更新日期：2010-11-09 00:00:00

abstract：:The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

journal_title：PLoS biology

authors： Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

更新日期：2013-01-01 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:In fungi, mating between partners depends on the molecular recognition of two peptidyl mating pheromones by their respective receptors. The fission yeast Schizosaccharomyces pombe (Sp) has two mating types, Plus (P) and Minus (M). The mating pheromones P-factor and M-factor, secreted by P and M cells, are recognized b...

journal_title：PLoS biology

authors： Seike T,Shimoda C,Niki H

更新日期：2019-01-22 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than other cells and might t...

journal_title：PLoS biology

authors： Silva J,Barrandon O,Nichols J,Kawaguchi J,Theunissen TW,Smith A

更新日期：2008-10-21 00:00:00

abstract：:Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to the relatively well-defined shape of bacteria and yeast c...

journal_title：PLoS biology

authors： Picone R,Ren X,Ivanovitch KD,Clarke JD,McKendry RA,Baum B

更新日期：2010-11-16 00:00:00