Abstract:
:Progress in science often begins with verbal hypotheses meant to explain why certain biological phenomena exist. An important purpose of mathematical models in evolutionary research, as in many other fields, is to act as “proof-of-concept” tests of the logic in verbal explanations, paralleling the way in which empirical data are used to test hypotheses. Because not all subfields of biology use mathematics for this purpose, misunderstandings of the function of proof-of-concept modeling are common. In the hope of facilitating communication, we discuss the role of proof-of-concept modeling in evolutionary biology.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Servedio MR,Brandvain Y,Dhole S,Fitzpatrick CL,Goldberg EE,Stern CA,Van Cleve J,Yeh DJdoi
10.1371/journal.pbio.1002017subject
Has Abstractpub_date
2014-12-09 00:00:00pages
e1002017issue
12eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-14-03027journal_volume
12pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::A lysosomal storage disease (LSD) results from deficient lysosomal enzyme activity, thus the substrate of the mutant enzyme accumulates in the lysosome, leading to pathology. In many but not all LSDs, the clinically most important mutations compromise the cellular folding of the enzyme, subjecting it to endoplasmic re...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060026
更新日期:2008-02-01 00:00:00
abstract::In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the los...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000587
更新日期:2011-02-01 00:00:00
abstract::Microbial endosymbiosis is widespread in animals, with major ecological and evolutionary implications. Successful symbiosis relies on efficient vertical transmission through host generations. However, when symbionts negatively affect host fitness, hosts are expected to evolve suppression of symbiont effects or transmi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000438
更新日期:2019-10-10 00:00:00
abstract::The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000194
更新日期:2009-09-01 00:00:00
abstract::Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000668
更新日期:2020-03-30 00:00:00
abstract::Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002253
更新日期:2015-09-22 00:00:00
abstract::The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002458
更新日期:2016-05-06 00:00:00
abstract::The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001329
更新日期:2012-01-01 00:00:00
abstract::The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparative analysis of XPD f...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001954
更新日期:2014-09-30 00:00:00
abstract::The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002047
更新日期:2017-06-29 00:00:00
abstract::The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006838
更新日期:2018-12-26 00:00:00
abstract::The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000615
更新日期:2011-05-01 00:00:00
abstract::Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000184
更新日期:2019-03-28 00:00:00
abstract::In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005561
更新日期:2018-11-28 00:00:00
abstract::The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of the misfolded chan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002462
更新日期:2016-05-11 00:00:00
abstract::PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000122
更新日期:2019-01-18 00:00:00
abstract::FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001389
更新日期:2012-01-01 00:00:00
abstract::Cancer research has become a global enterprise, and the number of researchers, as well as the cost for their activities, has skyrocketed. The budget for the National Cancer Institute of the United States National Institutes of Health alone was US$5.2 billion in 2015. Since most of the research is funded by public mone...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000314
更新日期:2016-09-29 00:00:00
abstract::The ability of cells to accurately control gene expression levels in response to extracellular cues is limited by the inherently stochastic nature of transcriptional regulation. A change in transcription factor (TF) activity results in changes in the expression of its targets, but the way in which cell-to-cell variabi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001528
更新日期:2013-01-01 00:00:00
abstract::Pollen tube (PT) reception in flowering plants describes the crosstalk between the male and female gametophytes upon PT arrival at the synergid cells of the ovule. It leads to PT growth arrest, rupture, and sperm cell release, and is thus essential to ensure double fertilization. Here, we describe TURAN (TUN) and EVAN...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002139
更新日期:2015-04-28 00:00:00
abstract::An increasing number of publishers and funding agencies require public data archiving (PDA) in open-access databases. PDA has obvious group benefits for the scientific community, but many researchers are reluctant to share their data publicly because of real or perceived individual costs. Improving participation in PD...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001779
更新日期:2014-01-28 00:00:00
abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002711
更新日期:2017-06-26 00:00:00
abstract::The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001143
更新日期:2011-09-01 00:00:00
abstract::Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006994
更新日期:2019-01-31 00:00:00
abstract::STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001923
更新日期:2014-08-05 00:00:00
abstract::In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2000111
更新日期:2016-08-15 00:00:00
abstract::The intrinsic flexibility of proteins allows them to undergo large conformational fluctuations in solution or upon interaction with other molecules. Proteins also commonly assemble into complexes with diverse quaternary structure arrangements. Here we investigate how the flexibility of individual protein chains influe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001870
更新日期:2014-05-27 00:00:00
abstract::Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluc...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001296
更新日期:2012-01-01 00:00:00
abstract::Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1002032
更新日期:2014-12-30 00:00:00
abstract::A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000677
更新日期:2020-06-12 00:00:00