NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

abstract：:To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...

journal_title：PLoS biology

authors： Wolfe BA,Takaki T,Petronczki M,Glotzer M

更新日期：2009-05-05 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:Total internal reflection fluorescence microscopy (TIR-FM) has become a powerful tool for studying clathrin-mediated endocytosis. However, due to difficulties in tracking and quantifying their heterogeneous dynamic behavior, detailed analyses have been restricted to a limited number of selected clathrin-coated pits (C...

journal_title：PLoS biology

authors： Loerke D,Mettlen M,Yarar D,Jaqaman K,Jaqaman H,Danuser G,Schmid SL

更新日期：2009-03-17 00:00:00

abstract：:During quiet resting behavior, involuntary movements are suppressed. Such movement control is attributed to cortico-basal ganglia loops, yet population dynamics within these loops during resting and their relation to involuntary movements are not well characterized. Here, we show by recording cortical and striatal ong...

journal_title：PLoS biology

authors： Klaus A,Plenz D

更新日期：2016-12-06 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...

journal_title：PLoS biology

authors： Yang C,Naya Y

更新日期：2020-11-18 00:00:00

abstract：:Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. He...

journal_title：PLoS biology

authors： Ni X,Zhang YE,Nègre N,Chen S,Long M,White KP

更新日期：2012-01-01 00:00:00

abstract：:The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately improved by analytical work, whether ensuring reproducible and well-document...

journal_title：PLoS biology

authors： Kucharski AJ,Funk S,Eggo RM

更新日期：2020-10-16 00:00:00

abstract：:The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...

journal_title：PLoS biology

authors： Ma S,Kwon HJ,Johng H,Zang K,Huang Z

更新日期：2013-01-01 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalam...

journal_title：PLoS biology

authors： Zhang H,Zhang G,Gonzalez FJ,Park SM,Cai D

更新日期：2011-07-01 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:How cell proliferation subsides as cells terminally differentiate remains largely enigmatic, although this phenomenon is central to the existence of multicellular organisms. Here, we show that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2....

journal_title：PLoS biology

authors： Kadri Z,Shimizu R,Ohneda O,Maouche-Chretien L,Gisselbrecht S,Yamamoto M,Romeo PH,Leboulch P,Chretien S

更新日期：2009-06-09 00:00:00

abstract：:In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the los...

journal_title：PLoS biology

authors： Newell PD,Boyd CD,Sondermann H,O'Toole GA

更新日期：2011-02-01 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...

journal_title：PLoS biology

authors： Krylova O,Earn DJD

更新日期：2020-12-21 00:00:00

abstract：:Polarized growth is maintained by both polarized exocytosis, which transports membrane components to specific locations on the cell cortex, and endocytosis, which retrieves these components before they can diffuse away. Despite functional links between these two transport pathways, they are generally considered to be ...

journal_title：PLoS biology

authors： Johansen J,Alfaro G,Beh CT

更新日期：2016-08-15 00:00:00

abstract：:The significance of symbioses between eukaryotic hosts and microbes extends from the organismal to the ecosystem level and underpins the health of Earth's most threatened marine ecosystems. Despite rapid growth in research on host-associated microbes, from individual microbial symbionts to host-associated consortia of...

journal_title：PLoS biology

authors： Wilkins LGE,Leray M,O'Dea A,Yuen B,Peixoto RS,Pereira TJ,Bik HM,Coil DA,Duffy JE,Herre EA,Lessios HA,Lucey NM,Mejia LC,Rasher DB,Sharp KH,Sogin EM,Thacker RW,Vega Thurber R,Wcislo WT,Wilbanks EG,Eisen JA

更新日期：2019-11-11 00:00:00

abstract：:Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...

journal_title：PLoS biology

authors： Colón-Thillet R,Hsieh E,Graf L,McLaughlin RN Jr,Young JM,Kochs G,Emerman M,Malik HS

更新日期：2019-10-01 00:00:00

abstract：:Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinemati...

journal_title：PLoS biology

authors： McGuire LM,Telian G,Laboy-Juárez KJ,Miyashita T,Lee DJ,Smith KA,Feldman DE

更新日期：2016-08-30 00:00:00

abstract：:Self-incompatibility (SI) is the flowering plant reproductive system in which self pollen tube growth is inhibited, thereby preventing self-fertilization. SI has evolved independently in several different flowering plant lineages. In all Brassicaceae species in which the molecular basis of SI has been investigated in ...

journal_title：PLoS biology

authors： Chantha SC,Herman AC,Platts AE,Vekemans X,Schoen DJ

更新日期：2013-01-01 00:00:00

abstract：:Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the prevalence of phylosymbiosis and its functional significance under highly controlled conditions b...

journal_title：PLoS biology

authors： Brooks AW,Kohl KD,Brucker RM,van Opstal EJ,Bordenstein SR

更新日期：2016-11-18 00:00:00

abstract：:The Open Science Prize was established with the following objectives: first, to encourage the crowdsourcing of open data to make breakthroughs that are of biomedical significance; second, to illustrate that funders can indeed work together when scientific interests are aligned; and finally, to encourage international ...

journal_title：PLoS biology

authors： Kittrie E,Atienza AA,Kiley R,Carr D,MacFarlane A,Pai V,Couch J,Bajkowski J,Bonner JF,Mietchen D,Bourne PE

更新日期：2017-08-01 00:00:00

abstract：:The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...

journal_title：PLoS biology

authors： Korkhin Y,Unligil UM,Littlefield O,Nelson PJ,Stuart DI,Sigler PB,Bell SD,Abrescia NG

更新日期：2009-05-01 00:00:00

abstract：:Sensory loss induces cross-modal plasticity, often resulting in altered performance in remaining sensory modalities. Whereas much is known about the macroscopic mechanisms underlying cross-modal plasticity, only scant information exists about its cellular and molecular underpinnings. We found that Caenorhabditis elega...

journal_title：PLoS biology

authors： Rabinowitch I,Laurent P,Zhao B,Walker D,Beets I,Schoofs L,Bai J,Schafer WR,Treinin M

更新日期：2016-01-08 00:00:00

abstract：:Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells. Here, we show that Escherichia coli cell lineages exhibit comparable pa...

journal_title：PLoS biology

authors： Proenca AM,Rang CU,Qiu A,Shi C,Chao L

更新日期：2019-05-23 00:00:00

abstract：:The causes and mechanisms of evolutionary diversification are central issues in biology. Geographic isolation is the traditional explanation for diversification, but recent theoretical and empirical studies have shown that frequency-dependent selection can drive diversification without isolation and that adaptive dive...

journal_title：PLoS biology

authors： Herron MD,Doebeli M

更新日期：2013-01-01 00:00:00

abstract：:The authors of "Relatedness, Conflict, and the Evolution of Eusociality" respond to objections raised by Martin Nowak and Benjamin Allen. ...

journal_title：PLoS biology

authors： Queller DC,Rong S,Liao X

更新日期：2015-04-24 00:00:00

abstract：:Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding o...

journal_title：PLoS biology

authors： Gilbert SF

更新日期：2017-12-28 00:00:00

abstract：:Despite many prior studies demonstrating offline behavioral gains in motor skills after sleep, the underlying neural mechanisms remain poorly understood. To investigate the neurophysiological basis for offline gains, we performed single-unit recordings in motor cortex as rats learned a skilled upper-limb task. We foun...

journal_title：PLoS biology

authors： Ramanathan DS,Gulati T,Ganguly K

更新日期：2015-09-18 00:00:00