ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.

abstract：:What explains why some groups of organisms, like birds, are so species rich? And what explains their extraordinary ecological diversity, ranging from large, flightless birds to small migratory species that fly thousand of kilometers every year? These and similar questions have spurred great interest in adaptive radiat...

journal_title：PLoS biology

authors： Moen D,Morlon H

更新日期：2014-05-06 00:00:00

abstract：:During quiet resting behavior, involuntary movements are suppressed. Such movement control is attributed to cortico-basal ganglia loops, yet population dynamics within these loops during resting and their relation to involuntary movements are not well characterized. Here, we show by recording cortical and striatal ong...

journal_title：PLoS biology

authors： Klaus A,Plenz D

更新日期：2016-12-06 00:00:00

abstract：:For decades, embalmed cadavers have played an important role in teaching anatomy to the scientists and doctors of the future. Most anatomy departments use a traditional formaldehyde-based embalming method, but formalin embalming makes the bodies very rigid, which limits their usefulness for procedures other than disse...

journal_title：PLoS biology

authors： Eisma R,Wilkinson T

更新日期：2014-10-21 00:00:00

abstract：:The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a plateau. Using experimental evolution with bacteriophage, we show here that the converse is also true. In populations small e...

journal_title：PLoS biology

authors： Silander OK,Tenaillon O,Chao L

更新日期：2007-04-01 00:00:00

abstract：:From a research perspective, the interest in biobanking continues to intensify. Governments and industry have invested heavily in biobanks, as exemplified by initiatives like the United Kingdom Biobank and United States' Precision Medicine Initiative. But despite this enthusiasm, many profound legal and ethical challe...

journal_title：PLoS biology

authors： Caulfield T,Murdoch B

更新日期：2017-07-25 00:00:00

abstract：:Pathogenicity of Pseudomonas syringae is dependent on a type III secretion system, which secretes a suite of virulence effector proteins into the host cytoplasm, and the production of a number of toxins such as coronatine (COR), which is a mimic of the plant hormone jasmonate-isoleuce (JA-Ile). Inside the plant cell, ...

journal_title：PLoS biology

authors： Gimenez-Ibanez S,Boter M,Fernández-Barbero G,Chini A,Rathjen JP,Solano R

更新日期：2014-02-18 00:00:00

abstract：:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...

journal_title：PLoS biology

authors： Ricard N,Simons M

更新日期：2015-05-15 00:00:00

abstract：:Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...

journal_title：PLoS biology

authors： Leitão-Gonçalves R,Carvalho-Santos Z,Francisco AP,Fioreze GT,Anjos M,Baltazar C,Elias AP,Itskov PM,Piper MDW,Ribeiro C

更新日期：2017-04-25 00:00:00

abstract：:Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...

journal_title：PLoS biology

authors： Lacroix R,Mukabana WR,Gouagna LC,Koella JC

更新日期：2005-09-01 00:00:00

abstract：:Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

journal_title：PLoS biology

authors： Varshney RK,Terauchi R,McCouch SR

更新日期：2014-06-10 00:00:00

abstract：:Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm for the generation of vascularized organoids (vOrganoids) consis...

journal_title：PLoS biology

authors： Shi Y,Sun L,Wang M,Liu J,Zhong S,Li R,Li P,Guo L,Fang A,Chen R,Ge WP,Wu Q,Wang X

更新日期：2020-05-13 00:00:00

abstract：:Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. However, recent preclinical and clinical observations of tumor initiati...

journal_title：PLoS biology

authors： Johnson KE,Howard G,Mo W,Strasser MK,Lima EABF,Huang S,Brock A

更新日期：2019-08-05 00:00:00

abstract：:STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatr...

journal_title：PLoS biology

authors： Xu J,Chatterjee M,Baguley TD,Brouillette J,Kurup P,Ghosh D,Kanyo J,Zhang Y,Seyb K,Ononenyi C,Foscue E,Anderson GM,Gresack J,Cuny GD,Glicksman MA,Greengard P,Lam TT,Tautz L,Nairn AC,Ellman JA,Lombroso PJ

更新日期：2014-08-05 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002125.]. ...

journal_title：PLoS biology

authors： Franco CA,Jones ML,Bernabeu MO,Geudens I,Mathivet T,Rosa A,Lopes FM,Lima AP,Ragab A,Collins RT,Phng LK,Coveney PV,Gerhardt H

更新日期：2015-05-14 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00

abstract：:We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...

journal_title：PLoS biology

authors： Ale-Agha N,Goy C,Jakobs P,Spyridopoulos I,Gonnissen S,Dyballa-Rukes N,Aufenvenne K,von Ameln F,Zurek M,Spannbrucker T,Eckermann O,Jakob S,Gorressen S,Abrams M,Grandoch M,Fischer JW,Köhrer K,Deenen R,Unfried K,Altsch

更新日期：2018-06-21 00:00:00

abstract：:The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...

journal_title：PLoS biology

authors： Yang C,Naya Y

更新日期：2020-11-18 00:00:00

abstract：:To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...

journal_title：PLoS biology

authors： Wolfe BA,Takaki T,Petronczki M,Glotzer M

更新日期：2009-05-05 00:00:00

abstract：:During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kin...

journal_title：PLoS biology

authors： Loc'h J,Blaud M,Réty S,Lebaron S,Deschamps P,Bareille J,Jombart J,Robert-Paganin J,Delbos L,Chardon F,Zhang E,Charenton C,Tollervey D,Leulliot N

更新日期：2014-05-13 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

journal_title：PLoS biology

authors： Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

更新日期：2018-09-27 00:00:00

abstract：:PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...

journal_title：PLoS biology

authors： Raia P,Carroni M,Henry E,Pehau-Arnaudet G,Brûlé S,Béguin P,Henneke G,Lindahl E,Delarue M,Sauguet L

更新日期：2019-01-18 00:00:00

abstract：:Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simpl...

journal_title：PLoS biology

authors： Augustin H,McGourty K,Allen MJ,Madem SK,Adcott J,Kerr F,Wong CT,Vincent A,Godenschwege T,Boucrot E,Partridge L

更新日期：2017-09-13 00:00:00

abstract：:Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS1...

journal_title：PLoS biology

authors： Cao Y,Xu H,Zhu Y,Shi MJ,Wei L,Zhang J,Cheng S,Shi Y,Tong H,Kang L,Lu L,Luo H,Yang X,Bai X,Wang R,Ma Y,Wang Y,Wang Z,Zhong K,Zhao BQ,Fan W

更新日期：2019-06-11 00:00:00

abstract：:Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

journal_title：PLoS biology

authors： Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

更新日期：2008-12-23 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...

journal_title：PLoS biology

authors： Yoshii T,Ahmad M,Helfrich-Förster C

更新日期：2009-04-07 00:00:00

abstract：:One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here, we use an unsupervised, systematic approach for associating genes a...

journal_title：PLoS biology

authors： Korbel JO,Doerks T,Jensen LJ,Perez-Iratxeta C,Kaczanowski S,Hooper SD,Andrade MA,Bork P

更新日期：2005-05-01 00:00:00

abstract：:Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...

journal_title：PLoS biology

authors： Barbeito-Andrés J,Schuler-Faccini L,Garcez PP

更新日期：2018-08-24 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00