Asymmetric diversification of mating pheromones in fission yeast.

abstract：:The evidence that diel patterns of physiology and behaviour in mammals are governed by circadian 'clocks' is based almost entirely on studies of nocturnal rodents. The emergent circadian paradigm, however, neglects the roles of energy metabolism and alimentary function (feeding and digestion) as determinants of activi...

journal_title：PLoS biology

authors： Hazlerigg DG,Tyler NJC

更新日期：2019-07-15 00:00:00

abstract：:During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kin...

journal_title：PLoS biology

authors： Loc'h J,Blaud M,Réty S,Lebaron S,Deschamps P,Bareille J,Jombart J,Robert-Paganin J,Delbos L,Chardon F,Zhang E,Charenton C,Tollervey D,Leulliot N

更新日期：2014-05-13 00:00:00

abstract：:Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic...

journal_title：PLoS biology

authors： Halley-Stott RP,Jullien J,Pasque V,Gurdon J

更新日期：2014-07-29 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events controlling this process in the human malaria parasite Plasmodium falcipa...

journal_title：PLoS biology

authors： McRobert L,Taylor CJ,Deng W,Fivelman QL,Cummings RM,Polley SD,Billker O,Baker DA

更新日期：2008-06-03 00:00:00

abstract：:How often do people visit the world's protected areas (PAs)? Despite PAs covering one-eighth of the land and being a major focus of nature-based recreation and tourism, we don't know. To address this, we compiled a globally-representative database of visits to PAs and built region-specific models predicting visit rate...

journal_title：PLoS biology

authors： Balmford A,Green JM,Anderson M,Beresford J,Huang C,Naidoo R,Walpole M,Manica A

更新日期：2015-02-24 00:00:00

abstract：:What do "microbes" have to do with social equity? These microorganisms are integral to our health, that of our natural environment, and even the "health" of the environments we build. The loss, gain, and retention of microorganisms-their flow between humans and the environment-can greatly impact our health. It is well...

journal_title：PLoS biology

authors： Ishaq SL,Rapp M,Byerly R,McClellan LS,O'Boyle MR,Nykanen A,Fuller PJ,Aas C,Stone JM,Killpatrick S,Uptegrove MM,Vischer A,Wolf H,Smallman F,Eymann H,Narode S,Stapleton E,Cioffi CC,Tavalire HF

更新日期：2019-11-26 00:00:00

abstract：:The array of vibrissae on a rat's face is the first stage in a high-resolution tactile sensing system. Progressing from rostral to caudal in any vibrissae row results in an increase in whisker length and thickness. This may, in turn, provide a systematic map of separate tactile channels governed by the mechanical prop...

journal_title：PLoS biology

authors： Gugig E,Sharma H,Azouz R

更新日期：2020-10-22 00:00:00

abstract：:RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs). RNA-induced silencing complexes (RISC) in human cells can be programmed by exogenously in...

journal_title：PLoS biology

authors： Chu CY,Rana TM

更新日期：2006-07-01 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00

abstract：:The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...

journal_title：PLoS biology

authors： Silva EA,Des Jarlais C,Lindstaedt B,Rotman E,Watkins ES

更新日期：2016-05-06 00:00:00

abstract：:Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional ...

journal_title：PLoS biology

authors： Vachon-Presseau E,Berger SE,Abdullah TB,Griffith JW,Schnitzer TJ,Apkarian AV

更新日期：2019-08-20 00:00:00

abstract：:Sensory loss induces cross-modal plasticity, often resulting in altered performance in remaining sensory modalities. Whereas much is known about the macroscopic mechanisms underlying cross-modal plasticity, only scant information exists about its cellular and molecular underpinnings. We found that Caenorhabditis elega...

journal_title：PLoS biology

authors： Rabinowitch I,Laurent P,Zhao B,Walker D,Beets I,Schoofs L,Bai J,Schafer WR,Treinin M

更新日期：2016-01-08 00:00:00

abstract：:The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these conditions. Unequivocal proof of such an association, however, requires independent replication of initial positive finding...

journal_title：PLoS biology

authors： Swarbrick MM,Waldenmaier B,Pennacchio LA,Lind DL,Cavazos MM,Geller F,Merriman R,Ustaszewska A,Malloy M,Scherag A,Hsueh WC,Rief W,Mauvais-Jarvis F,Pullinger CR,Kane JP,Dent R,McPherson R,Kwok PY,Hinney A,Hebebrand J

更新日期：2005-09-01 00:00:00

abstract：:The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp. p45/NRH2/PLAIDD is a p75 homologue and contains a death domain (DD). Here we report th...

journal_title：PLoS biology

authors： Vilar M,Sung TC,Chen Z,García-Carpio I,Fernandez EM,Xu J,Riek R,Lee KF

更新日期：2014-08-05 00:00:00

abstract：:Previously it was shown that male mice, when they encounter female mice or their pheromones, emit ultrasonic vocalizations with frequencies ranging over 30-110 kHz. Here, we show that these vocalizations have the characteristics of song, consisting of several different syllable types, whose temporal sequencing include...

journal_title：PLoS biology

authors： Holy TE,Guo Z

更新日期：2005-12-01 00:00:00

abstract：:Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

journal_title：PLoS biology

authors： Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

更新日期：2008-12-23 00:00:00

abstract：:We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modulated by substitutin...

journal_title：PLoS biology

authors： Chi YI,Martick M,Lares M,Kim R,Scott WG,Kim SH

更新日期：2008-09-30 00:00:00

abstract：:The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies. Cajal bodies are nuclear organelles involved in diverse functions such as processing ribonucleoproteins important for splicing. Here we identify the...

journal_title：PLoS biology

authors： Mahmoudi S,Henriksson S,Weibrecht I,Smith S,Söderberg O,Strömblad S,Wiman KG,Farnebo M

更新日期：2010-11-02 00:00:00

abstract：:Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial. Much recent research has emphasised the adaptive benefit of acquiring novel DNA, but here we argue instead that intragenomic conflict provides a coherent framewo...

journal_title：PLoS biology

authors： Croucher NJ,Mostowy R,Wymant C,Turner P,Bentley SD,Fraser C

更新日期：2016-03-02 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases. Molecular analyses have recently detailed the lipid antigen recognition strategies utilized by the invariant Vα24-Jα18 TCR rearrangements of iNKT cells, wh...

journal_title：PLoS biology

authors： López-Sagaseta J,Kung JE,Savage PB,Gumperz J,Adams EJ

更新日期：2012-01-01 00:00:00

abstract：:In nature, Escherichia coli are exposed to harsh and non-ideal growth environments-nutrients may be limiting, and cells are often challenged by oxidative stress. For E. coli cells confronting these realities, there appears to be a link between oxidative stress, methionine availability, and the enzyme that catalyzes th...

journal_title：PLoS biology

authors： Hondorp ER,Matthews RG

更新日期：2004-11-01 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas...

journal_title：PLoS biology

authors： Miller WL,Auchus RJ

更新日期：2019-04-03 00:00:00

abstract：:The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a plateau. Using experimental evolution with bacteriophage, we show here that the converse is also true. In populations small e...

journal_title：PLoS biology

authors： Silander OK,Tenaillon O,Chao L

更新日期：2007-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell ...

journal_title：PLoS biology

authors： Zhu K,Chen S,Sysoeva TA,You L

更新日期：2019-12-16 00:00:00

abstract：:The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo sup...

journal_title：PLoS biology

authors： Braitsch CM,Azizoglu DB,Htike Y,Barlow HR,Schnell U,Chaney CP,Carroll TJ,Stanger BZ,Cleaver O

更新日期：2019-07-19 00:00:00

abstract：:Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...

journal_title：PLoS biology

authors： Hayashi MJ,Ditye T,Harada T,Hashiguchi M,Sadato N,Carlson S,Walsh V,Kanai R

更新日期：2015-09-17 00:00:00

abstract：:Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a closed conformation. Since closed syntaxin is unable to interact ...

journal_title：PLoS biology

authors： Zilly FE,Sørensen JB,Jahn R,Lang T

更新日期：2006-10-01 00:00:00