Abstract:
:The evidence that diel patterns of physiology and behaviour in mammals are governed by circadian 'clocks' is based almost entirely on studies of nocturnal rodents. The emergent circadian paradigm, however, neglects the roles of energy metabolism and alimentary function (feeding and digestion) as determinants of activity pattern. The temporal control of activity varies widely across taxa, and ungulates, microtine rodents, and insectivores provide examples in which circadian timekeeping is vestigial. The nocturnal rodent/human paradigm of circadian organisation is unhelpful when considering the broader manifestation of activity patterns in mammals.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Hazlerigg DG,Tyler NJCdoi
10.1371/journal.pbio.3000360subject
Has Abstractpub_date
2019-07-15 00:00:00pages
e3000360issue
7eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-19-01051journal_volume
17pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip has been reported in many vertebrates. However, the knowledge about the subcellular dynamics and molecular mechanisms regulating directional neuronal migration in vivo is just beginning to emerge. Here we show by time-lapse ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000240
更新日期:2009-11-01 00:00:00
abstract::Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040112
更新日期:2006-05-01 00:00:00
abstract::In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantage. The resulting frequency-dependent selection can structure parasite populations into strains of limited genetic overlap. For the causative agent of malaria, Plasmodium falciparum, the hig...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000336
更新日期:2019-06-24 00:00:00
abstract::Meta-research is the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives. Given that science is the key driver of human progress, improving the efficiency of scientific investigation and yielding more credible and more useful research results can translate to major benefits. T...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005468
更新日期:2018-03-13 00:00:00
abstract::DEAD-box proteins are ubiquitous regulators of RNA biology. While commonly dubbed "helicases," their activities also include duplex annealing, adenosine triphosphate (ATP)-dependent RNA binding, and RNA-protein complex remodeling. Rok1, an essential DEAD-box protein, and its cofactor Rrp5 are required for ribosome ass...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002480
更新日期:2016-06-09 00:00:00
abstract::The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000102
更新日期:2009-05-01 00:00:00
abstract::The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000615
更新日期:2011-05-01 00:00:00
abstract::Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analys...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000482
更新日期:2019-12-05 00:00:00
abstract::The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001469
更新日期:2013-01-01 00:00:00
abstract::Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding o...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003691
更新日期:2017-12-28 00:00:00
abstract::The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor (D1R)- and D2 dopamine receptor (D2R)-expressing medium spiny neurons (MSNs). How various neurotransmitter inputs converging on common intracellular pathways are p...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000477
更新日期:2019-10-10 00:00:00
abstract::During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subtype and has been implicated in the development of insensitivity to an...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002330
更新日期:2015-12-30 00:00:00
abstract::Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000862
更新日期:2017-04-25 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040069
更新日期:2006-03-01 00:00:00
abstract::Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001926
更新日期:2014-08-12 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...
journal_title:PLoS biology
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pbio.1002619
更新日期:2018-01-25 00:00:00
abstract::Every year, ovarian cancer kills approximately 14,000 women in the United States and more than 140,000 women worldwide. Most of these deaths are caused by tumors of the serous histological type, which is rarely diagnosed before it has disseminated. By deep paired-end sequencing of mRNA from serous ovarian cancers, fol...
journal_title:PLoS biology
pub_type: 杂志文章,多中心研究
doi:10.1371/journal.pbio.1001156
更新日期:2011-09-01 00:00:00
abstract::Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a method that exploits ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005595
更新日期:2018-12-12 00:00:00
abstract::The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001623
更新日期:2013-01-01 00:00:00
abstract::Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains unclear how these FRC-derived mediators dampen T-cell responses and wheth...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000072
更新日期:2019-07-15 00:00:00
abstract::A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005952
更新日期:2018-11-01 00:00:00
abstract::The source of symmetry breaking in vertebrate oocytes is unknown. Animal-vegetal oocyte polarity is established by the Balbiani body (Bb), a conserved structure found in all animals examined that contains an aggregate of specific mRNAs, proteins, and organelles. The Bb specifies the oocyte vegetal pole, which is key t...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002335
更新日期:2016-01-07 00:00:00
abstract::Functional MRI (fMRI) studies have traditionally relied on intersubject normalization based on global brain morphology, which cannot establish proper functional correspondence between subjects due to substantial intersubject variability in functional organization. Here, we reliably identified a set of discrete, homolo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2007032
更新日期:2019-03-25 00:00:00
abstract::FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001389
更新日期:2012-01-01 00:00:00
abstract::Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000086
更新日期:2009-04-07 00:00:00
abstract::Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060084
更新日期:2008-04-08 00:00:00
abstract::The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030067
更新日期:2005-03-01 00:00:00
abstract::Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001914
更新日期:2014-07-29 00:00:00
abstract::Recent findings suggest that functional brain imaging might be used to identify consciousness in patients diagnosed with persistent vegetative state and minimally conscious state. Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats. ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000548
更新日期:2010-11-30 00:00:00
abstract::In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time. ...
journal_title:PLoS biology
pub_type: 社论
doi:10.1371/journal.pbio.3000992
更新日期:2020-10-22 00:00:00