Abstract:
:Functional MRI (fMRI) studies have traditionally relied on intersubject normalization based on global brain morphology, which cannot establish proper functional correspondence between subjects due to substantial intersubject variability in functional organization. Here, we reliably identified a set of discrete, homologous functional regions in individuals to improve intersubject alignment of fMRI data. These functional regions demonstrated marked intersubject variability in size, position, and connectivity. We found that previously reported intersubject variability in functional connectivity maps could be partially explained by variability in size and position of the functional regions. Importantly, individual differences in network topography are associated with individual differences in task-evoked activations, suggesting that these individually specified regions may serve as the "localizer" to improve the alignment of task-fMRI data. We demonstrated that aligning task-fMRI data using the regions derived from resting state fMRI may lead to increased statistical power of task-fMRI analyses. In addition, resting state functional connectivity among these homologous regions is able to capture the idiosyncrasies of subjects and better predict fluid intelligence (gF) than connectivity measures derived from group-level brain atlases. Critically, we showed that not only the connectivity but also the size and position of functional regions are related to human behavior. Collectively, these findings suggest that identifying homologous functional regions across individuals can benefit a wide range of studies in the investigation of connectivity, task activation, and brain-behavior associations.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Li M,Wang D,Ren J,Langs G,Stoecklein S,Brennan BP,Lu J,Chen H,Liu Hdoi
10.1371/journal.pbio.2007032subject
Has Abstractpub_date
2019-03-25 00:00:00pages
e2007032issue
3eissn
1544-9173issn
1545-7885pii
pbio.2007032journal_volume
17pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions withi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000306
更新日期:2010-02-09 00:00:00
abstract::The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000418
更新日期:2010-07-13 00:00:00
abstract::The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002399
更新日期:2018-01-22 00:00:00
abstract::Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To s...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004399
更新日期:2018-04-24 00:00:00
abstract::Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030031
更新日期:2005-02-01 00:00:00
abstract::Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060311
更新日期:2008-12-16 00:00:00
abstract::Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000493
更新日期:2010-09-28 00:00:00
abstract::Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated. Here we show that ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001695
更新日期:2013-10-01 00:00:00
abstract::The significance of symbioses between eukaryotic hosts and microbes extends from the organismal to the ecosystem level and underpins the health of Earth's most threatened marine ecosystems. Despite rapid growth in research on host-associated microbes, from individual microbial symbionts to host-associated consortia of...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000533
更新日期:2019-11-11 00:00:00
abstract::microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to precursor miRNA (pre-m...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030236
更新日期:2005-07-01 00:00:00
abstract::The cerebellum has been proposed to be a crucial component in the state estimation process that combines information from motor efferent and sensory afferent signals to produce a representation of the current state of the motor system. Such a state estimate of the moving human arm would be expected to be used when the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050316
更新日期:2007-11-01 00:00:00
abstract::Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity of opposing kinase signaling complexes has remained elusive. We report...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000612
更新日期:2011-04-01 00:00:00
abstract::The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. H...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020261
更新日期:2004-09-01 00:00:00
abstract::Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000744
更新日期:2020-06-19 00:00:00
abstract::CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005970
更新日期:2018-07-03 00:00:00
abstract::Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002148
更新日期:2015-05-15 00:00:00
abstract::Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003452
更新日期:2018-02-14 00:00:00
abstract::In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the los...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000587
更新日期:2011-02-01 00:00:00
abstract::Global warming is significantly altering arctic marine ecosystems. Specifically, the precipitous loss of sea ice is creating a dichotomy between ice-dependent polar bears and pinnipeds that are losing habitat and some cetaceans that are gaining habitat. While final outcomes are hard to predict for the many and varied ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006708
更新日期:2018-10-09 00:00:00
abstract::The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrat...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000606
更新日期:2020-07-20 00:00:00
abstract::Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002089
更新日期:2015-03-12 00:00:00
abstract::Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats. Here, we report that Drosophila larvae exhibit a novel appetitive feeding behavio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005570
更新日期:2018-08-07 00:00:00
abstract::While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000284
更新日期:2019-05-20 00:00:00
abstract::Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalami...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000829
更新日期:2020-10-13 00:00:00
abstract::A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002118
更新日期:2015-04-09 00:00:00
abstract::Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001034
更新日期:2020-12-28 00:00:00
abstract::The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000102
更新日期:2009-05-01 00:00:00
abstract::Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges. Here we show that natural primary immune responses against parasites generate bifun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001633
更新日期:2013-01-01 00:00:00
abstract::Total internal reflection fluorescence microscopy (TIR-FM) has become a powerful tool for studying clathrin-mediated endocytosis. However, due to difficulties in tracking and quantifying their heterogeneous dynamic behavior, detailed analyses have been restricted to a limited number of selected clathrin-coated pits (C...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000057
更新日期:2009-03-17 00:00:00
abstract::Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse model of pancreatic islet cell tumorigenesis can be used to meas...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050276
更新日期:2007-10-16 00:00:00