Mitosis gives a brief window of opportunity for a change in gene transcription.

Abstract:

:Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic chromatin is reprogrammed up to 100 times faster than interphase nuclei. We find that, as cells traverse mitosis, their genes pass through a temporary phase of unusually high responsiveness to oocyte reprogramming factors (mitotic advantage). Mitotic advantage is not explained by nuclear penetration, DNA modifications, histone acetylation, phosphorylation, methylation, nor by salt soluble chromosomal proteins. Our results suggest that histone H2A deubiquitination may account, at least in part, for the acquisition of mitotic advantage. They support the general principle that a temporary access of cytoplasmic factors to genes during mitosis may facilitate somatic cell nuclear reprogramming and the acquisition of new cell fates in normal development.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Halley-Stott RP,Jullien J,Pasque V,Gurdon J

doi

10.1371/journal.pbio.1001914

subject

Has Abstract

pub_date

2014-07-29 00:00:00

pages

e1001914

issue

7

eissn

1544-9173

issn

1545-7885

pii

PBIOLOGY-D-14-00928

journal_volume

12

pub_type

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