Control of apoptosis by asymmetric cell division.

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...

journal_title：PLoS biology

authors： Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CT

更新日期：2019-12-09 00:00:00

abstract：:Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...

journal_title：PLoS biology

authors： Lacroix R,Mukabana WR,Gouagna LC,Koella JC

更新日期：2005-09-01 00:00:00

abstract：:Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

journal_title：PLoS biology

authors： Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

更新日期：2020-12-07 00:00:00

abstract：:One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here, we use an unsupervised, systematic approach for associating genes a...

journal_title：PLoS biology

authors： Korbel JO,Doerks T,Jensen LJ,Perez-Iratxeta C,Kaczanowski S,Hooper SD,Andrade MA,Bork P

更新日期：2005-05-01 00:00:00

abstract：:During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluated the epigenetic landscape of the mouse myometrium during the pregnan...

journal_title：PLoS biology

authors： Shchuka VM,Abatti LE,Hou H,Khader N,Dorogin A,Wilson MD,Shynlova O,Mitchell JA

更新日期：2020-07-15 00:00:00

abstract：:Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...

journal_title：PLoS biology

authors： Hipfner DR,Cohen SM

更新日期：2003-11-01 00:00:00

abstract：:In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate the molecular mechan...

journal_title：PLoS biology

authors： Montaville P,Jégou A,Pernier J,Compper C,Guichard B,Mogessie B,Schuh M,Romet-Lemonne G,Carlier MF

更新日期：2014-02-25 00:00:00

abstract：:Malaria transmission is known to be strongly impacted by temperature. The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies. These studies, some dating back to the early part of last century, are often poorly controlled, have l...

journal_title：PLoS biology

authors： Shapiro LLM,Whitehead SA,Thomas MB

更新日期：2017-10-16 00:00:00

abstract：:Recent findings suggest that functional brain imaging might be used to identify consciousness in patients diagnosed with persistent vegetative state and minimally conscious state. Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats. ...

journal_title：PLoS biology

authors： Rafii MS,Brewer JB

更新日期：2010-11-30 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the nasc...

journal_title：PLoS biology

authors： Lintner NG,McClure KF,Petersen D,Londregan AT,Piotrowski DW,Wei L,Xiao J,Bolt M,Loria PM,Maguire B,Geoghegan KF,Huang A,Rolph T,Liras S,Doudna JA,Dullea RG,Cate JH

更新日期：2017-03-21 00:00:00

abstract：:Many living organisms transform inorganic atoms into highly ordered crystalline materials. An elegant example of such biomineralization processes is the production of nano-scale magnetic crystals in magnetotactic bacteria. Previous studies implicated the involvement of two putative serine proteases, MamE and MamO, dur...

journal_title：PLoS biology

authors： Hershey DM,Ren X,Melnyk RA,Browne PJ,Ozyamak E,Jones SR,Chang MC,Hurley JH,Komeili A

更新日期：2016-03-16 00:00:00

abstract：:Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...

journal_title：PLoS biology

authors： Hayashi MJ,Ditye T,Harada T,Hashiguchi M,Sadato N,Carlson S,Walsh V,Kanai R

更新日期：2015-09-17 00:00:00

abstract：:The ecologically significant shift in developmental strategy from planktotrophic (feeding) to lecithotrophic (nonfeeding) development in the sea urchin genus Heliocidaris is one of the most comprehensively studied life history transitions in any animal. Although the evolution of lecithotrophy involved substantial chan...

journal_title：PLoS biology

authors： Israel JW,Martik ML,Byrne M,Raff EC,Raff RA,McClay DR,Wray GA

更新日期：2016-03-04 00:00:00

abstract：:We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

journal_title：PLoS biology

authors： Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

更新日期：2006-03-01 00:00:00

abstract：:Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in local zinc concentration. To understand how microorganisms coordinate a dynamic response to changes in zinc availability at the molecular level, we evaluated the...

journal_title：PLoS biology

authors： Gilston BA,Wang S,Marcus MD,Canalizo-Hernández MA,Swindell EP,Xue Y,Mondragón A,O'Halloran TV

更新日期：2014-11-04 00:00:00

abstract：:Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we ident...

journal_title：PLoS biology

authors： Krishnamurthy SR,Janowski AB,Zhao G,Barouch D,Wang D

更新日期：2016-03-24 00:00:00

abstract：:Pollen tube (PT) reception in flowering plants describes the crosstalk between the male and female gametophytes upon PT arrival at the synergid cells of the ovule. It leads to PT growth arrest, rupture, and sperm cell release, and is thus essential to ensure double fertilization. Here, we describe TURAN (TUN) and EVAN...

journal_title：PLoS biology

authors： Lindner H,Kessler SA,Müller LM,Shimosato-Asano H,Boisson-Dernier A,Grossniklaus U

更新日期：2015-04-28 00:00:00

abstract：:Polarized growth is maintained by both polarized exocytosis, which transports membrane components to specific locations on the cell cortex, and endocytosis, which retrieves these components before they can diffuse away. Despite functional links between these two transport pathways, they are generally considered to be ...

journal_title：PLoS biology

authors： Johansen J,Alfaro G,Beh CT

更新日期：2016-08-15 00:00:00

abstract：:Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 sin...

journal_title：PLoS biology

authors： Boyko AR,Quignon P,Li L,Schoenebeck JJ,Degenhardt JD,Lohmueller KE,Zhao K,Brisbin A,Parker HG,vonHoldt BM,Cargill M,Auton A,Reynolds A,Elkahloun AG,Castelhano M,Mosher DS,Sutter NB,Johnson GS,Novembre J,Hubisz MJ,

更新日期：2010-08-10 00:00:00

abstract：:The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...

journal_title：PLoS biology

authors： de Sousa N,Rodríguez-Esteban G,Rojo-Laguna JI,Saló E,Adell T

更新日期：2018-01-22 00:00:00

abstract：:Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...

journal_title：PLoS biology

authors： Alerstam T,Rosén M,Bäckman J,Ericson PG,Hellgren O

更新日期：2007-08-01 00:00:00

abstract：:Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...

journal_title：PLoS biology

authors： Meharena HS,Fan X,Ahuja LG,Keshwani MM,McClendon CL,Chen AM,Adams JA,Taylor SS

更新日期：2016-11-30 00:00:00

abstract：:Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with,...

journal_title：PLoS biology

authors： Prendergast L,van Vuuren C,Kaczmarczyk A,Doering V,Hellwig D,Quinn N,Hoischen C,Diekmann S,Sullivan KF

更新日期：2011-06-01 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Recently, prominent theoretical linguists have argued for an explicit scenario for the evolution of the human language capacity on the basis of its computational properties. Concretely, the simplicity of a minimalist formulation of the operation Merge, which allows humans to recursively compute hierarchical relations ...

journal_title：PLoS biology

authors： Martins PT,Boeckx C

更新日期：2019-11-27 00:00:00

abstract：:Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...

journal_title：PLoS biology

authors： Arnoldini M,Vizcarra IA,Peña-Miller R,Stocker N,Diard M,Vogel V,Beardmore RE,Hardt WD,Ackermann M

更新日期：2014-08-19 00:00:00

abstract：:Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity of opposing kinase signaling complexes has remained elusive. We report...

journal_title：PLoS biology

authors： Merrill RA,Dagda RK,Dickey AS,Cribbs JT,Green SH,Usachev YM,Strack S

更新日期：2011-04-01 00:00:00