Polarized Exocytosis Induces Compensatory Endocytosis by Sec4p-Regulated Cortical Actin Polymerization.

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. H...

journal_title：PLoS biology

authors： Schnatwinkel C,Christoforidis S,Lindsay MR,Uttenweiler-Joseph S,Wilm M,Parton RG,Zerial M

更新日期：2004-09-01 00:00:00

abstract：:Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...

journal_title：PLoS biology

authors： Yoshii T,Ahmad M,Helfrich-Förster C

更新日期：2009-04-07 00:00:00

abstract：:Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begi...

journal_title：PLoS biology

authors： Chevin LM,Lande R,Mace GM

更新日期：2010-04-27 00:00:00

abstract：:One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejecte...

journal_title：PLoS biology

authors： McGaugh SE,Heil CS,Manzano-Winkler B,Loewe L,Goldstein S,Himmel TL,Noor MA

更新日期：2012-01-01 00:00:00

abstract：:We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

journal_title：PLoS biology

authors： Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

更新日期：2006-03-01 00:00:00

abstract：:FtsZ is a tubulin-like GTPase that is the major cytoskeletal protein in bacterial cell division. It polymerizes into a ring, called the Z ring, at the division site and acts as a scaffold to recruit other division proteins to this site as well as providing a contractile force for cytokinesis. To understand how FtsZ pe...

journal_title：PLoS biology

authors： Strauss MP,Liew AT,Turnbull L,Whitchurch CB,Monahan LG,Harry EJ

更新日期：2012-01-01 00:00:00

abstract：:Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

journal_title：PLoS biology

authors： Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

更新日期：2020-12-07 00:00:00

abstract：:Although amyloid fibrillation is generally believed to be a nucleation-dependent process, the nuclei are largely structurally uncharacterized. This is in part due to the inherent experimental challenge associated with structural descriptions of individual components in a dynamic multi-component equilibrium. There are ...

journal_title：PLoS biology

authors： Vestergaard B,Groenning M,Roessle M,Kastrup JS,van de Weert M,Flink JM,Frokjaer S,Gajhede M,Svergun DI

更新日期：2007-05-01 00:00:00

abstract：:Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-embryos display an identical phenotype, indicating that these ce...

journal_title：PLoS biology

authors： Lee KM,Wilson GJ,Pingen M,Fukuoka A,Hansell CAH,Bartolini R,Medina-Ruiz L,Graham GJ

更新日期：2019-05-29 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2001154.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2017-05-09 00:00:00

abstract：:While the timing of neuronal activity in the olfactory bulb (OB) relative to sniffing has been the object of many studies, the behavioral relevance of timing information generated by patterned activation within the bulbar response has not been explored. Here we show, using sniff-triggered, dynamic, 2-D, optogenetic st...

journal_title：PLoS biology

authors： Rebello MR,McTavish TS,Willhite DC,Short SM,Shepherd GM,Verhagen JV

更新日期：2014-12-16 00:00:00

abstract：:Over the past decade, the high-dose refuge (HDR) strategy, aimed at delaying the evolution of pest resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops, became mandatory in the United States and is being discussed for Europe. However, precopulatory dispersal and the mating rate between residen...

journal_title：PLoS biology

authors： Dalecky A,Ponsard S,Bailey RI,Pélissier C,Bourguet D

更新日期：2006-06-01 00:00:00

abstract：:The rapid destruction of the planet's biodiversity has prompted the nations of the world to set a target of achieving a significant reduction in the rate of loss of biodiversity by 2010. However, we do not yet have an adequate way of monitoring progress towards achieving this target. Here we present a method for produ...

journal_title：PLoS biology

authors： Butchart SH,Stattersfield AJ,Bennun LA,Shutes SM,Akçakaya HR,Baillie JE,Stuart SN,Hilton-Taylor C,Mace GM

更新日期：2004-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000311.]. ...

journal_title：PLoS biology

authors： Simeon R,Jiang M,Chamoun-Emanuelli AM,Yu H,Zhang Y,Meng R,Peng Z,Jakana J,Zhang J,Feng H,Chen Z

更新日期：2019-10-04 00:00:00

abstract：:Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...

journal_title：PLoS biology

authors： Grent-'t-Jong T,Woldorff MG

更新日期：2007-01-01 00:00:00

abstract：:Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...

journal_title：PLoS biology

authors： Maia Chagas A

更新日期：2018-09-27 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...

journal_title：PLoS biology

authors： Crawley D,Zhang L,Jones EJH,Ahmad J,Oakley B,San José Cáceres A,Charman T,Buitelaar JK,Murphy DGM,Chatham C,den Ouden H,Loth E,EU-AIMS LEAP group.

更新日期：2020-10-27 00:00:00

abstract：:The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role...

journal_title：PLoS biology

authors： Landsman L,Nijagal A,Whitchurch TJ,Vanderlaan RL,Zimmer WE,Mackenzie TC,Hebrok M

更新日期：2011-09-01 00:00:00

abstract：:The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...

journal_title：PLoS biology

authors： Avila I,Lin SC

更新日期：2014-03-18 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...

journal_title：PLoS biology

authors： Fatsis-Kavalopoulos N,Roemhild R,Tang PC,Kreuger J,Andersson DI

更新日期：2020-09-17 00:00:00

abstract：:Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. These pathological fea...

journal_title：PLoS biology

authors： Gallego-Delgado P,James R,Browne E,Meng J,Umashankar S,Tan L,Picon C,Mazarakis ND,Faisal AA,Howell OW,Reynolds R

更新日期：2020-12-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2006145.]. ...

journal_title：PLoS biology

authors： Saran AR,Kalinowska D,Oh S,Janknecht R,DiTacchio L

更新日期：2019-08-21 00:00:00

abstract：:Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However,...

journal_title：PLoS biology

authors： Thorburn A

更新日期：2014-10-14 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell ...

journal_title：PLoS biology

authors： Hatzold J,Conradt B

更新日期：2008-04-08 00:00:00